Results 61 to 70 of about 1,513,832 (269)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Comparing Controlled System Synthesis and Suppression Enforcement [PDF]
International Journal on Software Tools for Technology Transfer, 2019 Runtime enforcement and control system synthesis are two verication techniques that automate the process of transforming an erroneous system into a valid one. As both techniques can modify the behaviour of a system to prevent erroneous executions, they are both ideal for ensuring safety.
Luca Aceto +3 more
openaire +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Synthesis for Human-in-the-Loop Control Systems [PDF]
, 2014 Several control systems in safety-critical applications involve the interaction of an autonomous controller with one or more human operators. Examples include pilots interacting with an autopilot system in an aircraft, and a driver interacting with automated driver-assistance features in an automobile.
Wenchao Li 0001 +3 more
openaire +1 more source
Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Combined motion control of hydraulic boom based on dynamic surface adaptive fuzzy sliding mode
The Journal of Engineering, 2018 The lifting mechanism on the transfer vehicle is a common electromechanical–hydraulic system. In order to overcome the non-linear and interference that exist in the hydraulic boom combined motion process, a dynamic surface adaptive fuzzy sliding mode ...
Rongan Pan +4 more
doaj +1 more source
Research on compliant configuration of hydraulic manipulator with passive following characteristic
The Journal of Engineering, 2020 To decrease the injury caused by an accidental collision between the hydraulic manipulator and human, a hydraulic rotating angle self-servo compliant robot driver joint is designed. Based on this joint, a variable stiffness passive servo-hydraulic rotary
Lin Jiang +5 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source