Results 161 to 170 of about 17,312,778 (333)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Enhancing Monte Carlo integration by control variates and statistical learning
This thesis focuses on enhancing Monte Carlo integration through the use of control variates, a variance reduction technique involving special functions with known integrals.
Zhuman, Aigerim
core
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Schwinger-Dyson control variates for lattice fermions
Previous work has shown that high-quality control variates for lattice Monte Carlo methods may be constructed from lattice Schwinger-Dyson relations.
Lawrence, Scott
core
Control variates for quasi-Monte Carlo
, 2003 Quasi-Monte Carlo (QMC) methods have begun to displace ordinary Monte Carlo (MC) methods in many practical problems. It is natural and obvious to combine QMC methods with traditional variance reduction techniques used in MC sampling, such as control ...
Fred J. Hickernell +3 more
core
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
BMC OphthalmologyPurpose To investigate and compare the effectiveness of 0.01% low-dose atropine (LA) and orthokeratology lenses (OK) monotherapy versus single-vision spectacles (SV) in controlling low myopia in clinical settings.
Xiaona Sun +4 more
doaj +1 more source
Control variates for sensitivity estimation [PDF]
Proceedings of the 2010 Winter Simulation Conference, 2010 Tarik Borogovac, Na Sun, Pirooz Vakili
openaire +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source