Results 161 to 170 of about 40,682 (295)

Multivariate associations of motor performance, sleep quality, depressive symptoms, and grey matter volume in younger and mid-to-older adults. [PDF]

Sci Rep
Küppers V, Bi H, Nicolaisen-Sobesky E, Hoffstaedter F, Yeo BTT, Drzezga A, Eickhoff SB, Tahmasian M.   +7 more
europepmc   +1 more source

Robust Control with Controller Variation for Controller Reduction

IEEJ Transactions on Electronics, Information and Systems, 2001
Ryuichi Satoh, Takao Watanabe, Keiichiro Yasuda   +2 more
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Autonomous artificial intelligence prescribing a drug to prevent severe acute graft-versus-host disease in HLA-haploidentical transplants. [PDF]

Nat Commun
Chen J, Cao Y, Feng Y, Qi S, Yang D, Hu Y, Pang A, Shen Q, Luo J, Gong X, Zhang R, Zhai X, Li X, Yan W, Zhang X, Chen M, Niu M, Wei J, Liang C, Zhai W, Zhao N, Liu X, Liu S, Zhai W, Li R, Shao X, Zhang D, Wang M, Pan P, Xu M, Zhang W, Xu Y, Zhu X, Guo Y, Wang H, Song Z, Gale RP, Han M, Feng S, Jiang E.   +39 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Flexibility of exercise capacity during nestling feeding in blue tits. [PDF]

J Exp Biol
Engert ER, Nord A, Andreasson F, Nilsson JÅ.   +3 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

ESPLSM: An Efficient and Interpretable Mediation Analysis Framework Using Sparse Envelopes. [PDF]

Stat Med
Park Y, Su Z.
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Concomitant Dysregulation of Cerebral Vasoreactivity and Arterial Blood Pressure Is Closely Related in Patients with Carotid Stenosis. [PDF]

Life (Basel)
Pál H, Magyar-Stang R, Csányi B, Gaál A, Mihály Z, Czinege Z, Sótonyi P, Horváth T, Dobi B, Bereczki D, Koller A, Debreczeni R.   +11 more
europepmc   +1 more source