Results 61 to 70 of about 918,355 (214)

Gastroresistant coating of HPC capsules prepared by Injection-Molding

, 2013
Pulsatile release capsules made of a swellable/ erodible polymer (HPC), prepared by injection molding, were preliminarily evaluated as substrates in coating processes.
E. Macchi, L. Zema, A. Gazzaniga, L. A. Felton   +3 more
core  

Multiple-Unit Swellable/Erodible Delivery System for Oral Pulsatile Release: Preliminary Stability and In Vivo Evaluation

, 2012
An oral multiple-unit pulsatile delivery system was evaluated for in vivo performance and physical stability. This system encompassed a minitablet core, an HPMC layer and an outer flexible and increasingly permeable acrylic film aimed at prolonging the ...
A. Maroni, A. Melocchi, A. Gazzaniga, L. Palugan, G. Loreti, M.D. Del Curto   +5 more
core  

Development of a Thiolated Carboxymethyl tara gum derivative with enhanced mucoadhesive and rheological behavior

Carbohydrate Polymer Technologies and Applications
The rational design of thiolated polysaccharides offers new opportunities to enhance the performance of gastroretentive drug delivery systems by improving mucoadhesive and rheological properties.
Manuel Pariguana, Liz Gonzalez, Clément de Loubens, Esteban Vargas, Adolfo Marican, Ricardo Castro, Gustavo Cabrera-Barjas, Esteban F. Durán-Lara   +7 more
doaj   +1 more source

Develop and Validate an Isocratic HPLC Method for Separation of Five Primary Derivatives of Catechin

, 2011
The aims of this study are to develop a simple, rapid and accurate isocratic HPLC analytical method to determine the most common five catechin derivatives; to validate the method by measuring the specificity, linearity, repeatability, intermediate ...
Martini, Nataly, Wen, Jingyuan, Li, D, Wu, Zimei   +3 more
core  

A high-efficiency and selective fluorescent assay for the detection of tetracyclines

Scientific Reports
Tetracyclines (TCs) rank second globally in the use of animal infection therapy and animal husbandry as growth promoters among all antibiotics. However, large amounts of TCs residue in food products and more than 75% of TCs are excreted into the ...
Jingqiao Guo, Jianhui Xin, Jine Wang, Zhen Li, Jianlei Yang, Xue Yu, Mengxia Yan, Jiangyang Mo   +7 more
doaj   +1 more source

Tumor cells targetable graphene oxide doped microneedle for synergistic photothermal-chemotherapy treatment of melanoma

Journal of Pharmaceutical Analysis
Melanoma is characterized by high malignancy, ranking the third among skin malignancies, and is associated with lack of specific treatment options and poor prognosis. Therefore, the development of effective therapies for melanoma is imperative.
Zhiqiang Zhang, Junfang Ke, Yuxin Dai, Chenxi Fang, Yunfeng Dai, Chen Wang, Meitao Duan, Jungang Ren, Ming Chen, Chen Wang   +9 more
doaj   +1 more source

In vitro Evaluation of a Multiple-Unit Formulation for Oral Colonic Release of Insulin

, 2013
SUMMARY A multiple-unit formulation for time-dependent colonic release of insulin was prepared and evaluated. Minitablet cores containing the protein drug along with a permeation enhancer, sodium glycocholate, in a 1:10 ratio were in turn spray-coated ...
A. Maroni, E. Macchi, M. Cerea, A. Gazzaniga, L. Palugan, G. Loreti, M.D. Del Curto   +6 more
core  

Innovative Controlled-Release Systems for Fucoxanthin: Research Progress and Applications

Fucoxanthin, a marine-derived carotenoid primarily sourced from algae and microalgae, holds significant potential for pharmaceutical and nutraceutical applications.
Mengran Guo, Shiyan Wang, Zhaohui Jin
core   +1 more source

PEG as a spacer arm markedly increases the immunogenicity of meningococcal group Y polysaccharide conjugate vaccine

, 2013
Neisseria meningitidis is a life-threatening pathogen that causes meningitis and other clinical manifestations. As a key virulence determinant, meningococcal capsular polysaccharide (PS) can be used to prevent meningococcal diseases. Conjugation of PS to
Fan, Bei, Hu, Tao, Huang, Qingrui, Li, Dongxia, Ma, Xiaowei, Ma, Guanghui, Su, Zhiguo, Kang, Aijun, An, Wenqi   +8 more
core   +1 more source

Controlled release of testosterone and estradiol-17 β from biodegradable cylinders

, 1994
A controlled release device for the hormones, testosterone and estradiol-17 β, was developed by coating a melt extruded hormone/poly (ϵ-caprolactone) cylinder with pure polylactide.
Gonzal, A., Pichora, D., Zhang, X., Wyss, U.P., Marte, Clarissa L., Goosen, M.F.A.   +5 more
core   +1 more source