Results 71 to 80 of about 4,232,192 (254)

Photocrosslinked microgels for oral delivery of macromolecular based-therapeutics

, 2015
In this work we present the fabrication of planar micro-hydrogels serving as vehicle for oral delivery of poorly bioavailable drugs. Microfabricated gels were prepared by means of selective exposure of aqueous solutions of poly(vinylpyrrolidone) (PVP) to
Faralli, A., Larsen, N. B., GRASSI, Mario, Mateiu, R. V., Müllertz, A., Marizza, P., Boisen, A., Keller, S. S.   +7 more
core  

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

High-entropy layered double hydroxide nanosheets reprogram tumor homeostasis for ultrasound-enhanced pyroptosis-mediated immunotherapy

Journal of Nanobiotechnology
Developing redox nanozymes able to disrupt cellular homeostasis and promoting immunotherapy offers great potentials to develop highly efficient cancer therapy, but remains challenging.
Xueting Yang, Manman Xu, Yashuo Jiang, Xiangling Gu, Chao Zhu, Yaqing Ge, Jing Li, Zheng Mo, Hongbin Qi, Xiaofei Liu   +9 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Multiple-Unit Swellable/Erodible Delivery System for Oral Pulsatile Release: Preliminary Stability and In Vivo Evaluation

, 2012
An oral multiple-unit pulsatile delivery system was evaluated for in vivo performance and physical stability. This system encompassed a minitablet core, an HPMC layer and an outer flexible and increasingly permeable acrylic film aimed at prolonging the ...
A. Maroni, A. Melocchi, A. Gazzaniga, L. Palugan, G. Loreti, M.D. Del Curto   +5 more
core   +2 more sources

Doxorubicin delivery by pYEEIE peptide-functionalized rhodiola rosea-derived exosome-like nanovesicles for targeted melanoma therapy

Frontiers in Pharmacology
IntroductionMelanoma is the most common cause of skin cancer-related deaths due to its aggressive nature. Plant-derived exosome-like nanovesicles (PELNs) are promising natural nanoparticles for therapeutic applications owing to their biocompatibility and
Meitao Duan, Binbin Chen, Xue Yi, Ahmed Mahal, Linwei Song, Moxun Xu, Ahmad J. Obaidullah, Shuwei Yu, Chen Wang, Chen Wang   +9 more
doaj   +1 more source

Modeling of drug release from a polymeric matrix

, 1997
Proceedings of the Controlled Release Society ...
GRASSI, Mario, PRICL, SABRINA, Carli F., Colombo I., LAPASIN, ROMANO   +4 more
core  

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source