Results 71 to 80 of about 410,044 (303)

Faire bifurquer le tourisme hivernal ? Controverses et mobilisations socio-environnementales autour de la transition écologique dans une station alpine (La Clusaz, France)

open access: yesMondes du Tourisme
Based on the case of the project to create a high-altitude reservoir at La Clusaz ski resort in France, this article analyses the opposing appropriations of the so-called ecological transition in the mountains.
Mikaël Chambru, Marion Picard
doaj   +1 more source

Controversia y discurso histórico en la temprana Edad Moderna

open access: yesCriticón, 2019
This article surveys the theoretical discourse about the forms and uses of controversy in early modern Spanish historiography. This discourse is examined in the light of the rise of history as a useful resource for polemics.
Cesc Esteve
doaj   +1 more source

On answering accusations in controversies [PDF]

open access: yes, 2009
Accusations are a very frequent type of speech act both in everyday life and in formal controversies, and answering accusations is a sophisticated type of linguistic practice well worth analysing from a pragmatic point of view.
Fritz, Gerd
core  

Revisiting the Althusser/E. P. Thompson-Controversy: Towards a Marxist theory of communication [PDF]

open access: yes, 2019
This essay revisits the controversy between Louis Althusser’s Marxist structuralism and Edward P. Thompson’s Marxist humanism. It draws conclusions from this controversy for the foundations of the Marxist theory of communication.
Fuchs, Christian
core   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

„Orlové literární revoluce.“ F. X. Šalda a/versus Arnošt Procházka (a Moderní revue) || ‘The Eagles of Literary Revolution’: F. X. Šalda and / versus Arnošt Procházka (and Moderní Revue) [PDF]

open access: yesSlovo a Smysl, 2018
The development of a professional network, as well as long-standing disputes, among the most prominent representatives of Czech modernism at the turn of the 19th and 20th centuries — F. X.
Luboš Merhaut
doaj  

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

open access: yesMolecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh   +11 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

Le créationnisme dans les programmes scolaires turcs : l’ombre de l’antiscientisme

open access: yesRevue Internationale d’Éducation de Sèvres, 2018
The theory of evolution was recently withdrawn from the biology secondary school curriculum in Turkey, where the teaching of science, technology, engineering and mathematics is nonetheless considered an education priority.
Deniz Peker
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

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