Results 61 to 70 of about 348,009 (316)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Election TV Debate and ‘FactCheckUK’ controversy – what now? [PDF]

open access: yes, 2019
Centre for Brexit Studies Researcher David Hearne has shared his views, thoughts and expertise around the current General Election proceedings, ITV’s Election Debate and the controversy surrounding the ‘FactCheckUK’ Twitter ...
Hearne, David
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Epilogue: Controversy and Fetal Research : The Swedish Case

open access: yes
This epilogue draws together and expands on discussions in the volume in order to highlight the issue of public controversy around the scientific uses of fetal material during the Swedish postwar period.
Jülich, Solveig,
core   +1 more source

How Canadians Communicate VI: Food Promotion, Consumption, and Controversy by Charlene Elliott (Ed.)

open access: yesCanadian Food Studies, 2016
Elliott’s collection brings communication studies to the core of food studies, and this makes it a long-overdue book. While not all authors are communication scholars, the range of topics covered in the book are representative of how enmeshed the study ...
Kathy Dobson   +8 more
doaj   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

open access: yesFEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

What makes Geography a worthwhile school subject? An exploration of the current controversy in geography teaching

open access: yes, 2019
Geography as a school subject is in controversy. This controversy is given expression in an on-going debate between the opposing views of two leading academics Alex Standish and David Lambert.
Haden-Walker, James
core   +1 more source

Plantes transgéniques, expertise et action publique : évolution de la place et du rôle de la CGB de 1986 à 20061

open access: yesOléagineux, Corps gras, Lipides, 2007
Through the history of the Commission du Génie Biomoléculaire, we analyse the transformations of the expertise and regulation of GM crops in France since 1986.
Bonneuil Christophe, Joly Pierre-Benoît
doaj   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

open access: yesFEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo   +7 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

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