Results 41 to 50 of about 410,044 (303)
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Manipulation et information fictionnelle
Communication, 2010 On December 13, 2006, Radio Télévision Belge Francophone (RTBF) interrupted its regular programming with a special bulletin to report/broadcast a false news story : Flanders had seceded and unilaterally declared its independence.
Jean-Paul Dufiet
doaj +1 more source
Building On Controversy : Developing Architectural Dialogues on Controversial Sites
, 2020 This thesis explores how controversial sites that are in stasis, like the old memorial library in Halifax, can be transformed into architecture. As the public becomes more involved in architectural design process the occurrence of sites in stasis like ...
Ramadan, Makenzie
core
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Une production dystopique ? Images, discours et conditions de travail dans l’industrie vidéoludique
Images du Travail, Travail des ImagesThere years after the controversial release of Cyberpunk 2077 (CD Projekt RED, 2020) and its return to favor with the Phantom Liberty extension, this article returns to the causes and consequences of this scandal.
Flavie Falais
doaj +1 more source
Managing Relational Legacies: Lessons from British Columbia, Canada
Administrative Sciences, 2014 Issues related to company-community relations and the social license to operate have emerged as strategic business issues. This paper aims to contribute to the growing body of research on long-term company-community relations.
Sofiane Baba, Emmanuel Raufflet
doaj +1 more source
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
Argumentation et Analyse du Discours, 2023 This “critical reflection” examines the way in which Jean-Claude Guerrini's two books (2019 and 2022) Values in Argument: The Legacy of Chaïm Perelman and Value Conflicts and Bullfighting: An Argumentative Study of Controversy deal with the argumentation
Roselyne Koren
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Trace element zinc metabolism and its relation to tumors
Frontiers in EndocrinologyZinc is an essential trace element in the human body, playing a crucial role in cellular metabolism.Dysregulation of zinc homeostasis can lead to abnormal cellular metabolism, contributing to diseases and closely related to tumor development.
Guiping Yao +8 more
doaj +1 more source