Results 41 to 50 of about 1,246,795 (299)

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider   +4 more
wiley   +1 more source

Foreword: The Perpetual Controversy [PDF]

open access: yes, 2008
[Excerpt] “Two qualities of American capital punishment perhaps explain its ability to command the attention of the Court, year by year, decade after decade. First, an exceptionally talented and dedicated specialist capital defense bar continually mounts
Johnson, Christopher M.
core   +1 more source

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

Une production dystopique ? Images, discours et conditions de travail dans l’industrie vidéoludique

open access: yesImages du Travail, Travail des Images
There years after the controversial release of Cyberpunk 2077 (CD Projekt RED, 2020) and its return to favor with the Phantom Liberty extension, this article returns to the causes and consequences of this scandal.
Flavie Falais
doaj   +1 more source

Résistances catholiques au protocole de Maputo. Mobilisations et controverses autour de la libéralisation de l’avortement en Afrique

open access: yesGenre, Sexualité et Société, 2017
This article investigates the Catholics opposition to the ratification of the Additional Protocol to the African Charter on Human and Peoples’ Rights on the Rights of Women in Africa (Maputo Protocol). This Protocol states among other things the right of
Lison Guignard
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

open access: yesFEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin   +2 more
wiley   +1 more source

Got Controversy - Milk Does [PDF]

open access: yes, 2008
This article analyzes ongoing controversy over how to best label rBST-free milk. Recombinant bovine somatotropin is a genetically engineered drug administered by some farmers to their dairy herds to increase milk production. FDA first approved its use in
McCabe, Margaret Sova
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Trace element zinc metabolism and its relation to tumors

open access: yesFrontiers in Endocrinology
Zinc is an essential trace element in the human body, playing a crucial role in cellular metabolism.Dysregulation of zinc homeostasis can lead to abnormal cellular metabolism, contributing to diseases and closely related to tumor development.
Guiping Yao   +8 more
doaj   +1 more source

Manipulation et information fictionnelle

open access: yesCommunication, 2010
On December 13, 2006, Radio Télévision Belge Francophone (RTBF) interrupted its regular programming with a special bulletin to report/broadcast a false news story : Flanders had seceded and unilaterally declared its independence.
Jean-Paul Dufiet
doaj   +1 more source

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