Results 1 to 10 of about 299 (128)

The first Conus genome assembly reveals a primary genetic central dogma of conopeptides in C. betulinus [PDF]

Cell Discovery, 2021
Although there are various Conus species with publicly available transcriptome and proteome data, no genome assembly has been reported yet. Here, using Chinese tubular cone snail (C.
Chao Peng, Yu Huang, Chao Bian, Jia Li, Jie Liu, Kai Zhang, Xinxin You, Zhilong Lin, Yanbin He, Jieming Chen, Yunyun Lv, Zhiqiang Ruan, Xinhui Zhang, Yunhai Yi, Yanping Li, Xueqiang Lin, Ruobo Gu, Junmin Xu, Jia’an Yang, Chongxu Fan, Ge Yao, Ji-Sheng Chen, Hui Jiang, Bingmiao Gao, Qiong Shi   +24 more
doaj   +7 more sources

A Transcriptomic Survey of Ion Channel-Based Conotoxins in the Chinese Tubular Cone Snail (Conus betulinus) [PDF]

Marine Drugs, 2017
Conotoxins in the venom of cone snails (Conus spp.) are a mixture of active peptides that work as blockers, agonists, antagonists, or inactivators of various ion channels.
Yu Huang, Chao Peng, Yunhai Yi, Bingmiao Gao, Qiong Shi   +4 more
doaj   +7 more sources

The complete mitochondrial DNA genome of a cone snail, Conus betulinus (Neogastropoda: Conidae), from the South China sea [PDF]

Mitochondrial DNA. Part B. Resources, 2021
The complete mitochondrial genome of the tubular cone snail Conus betulinus is presented in this study. The C. betulinus mitochondrial genome was 16,240 bp with 13 protein-coding genes (PCGs), 22 transfer RNA (tRNA) genes, 2 ribosomal RNA (rRNA) genes ...
Yanling Liao, Jinxing Fu, Bingmiao Gao, Tianle Tang   +3 more
doaj   +5 more sources

High-throughput identification of novel conotoxins from the Chinese tubular cone snail (Conus betulinus) by multi-transcriptome sequencing. [PDF]

Gigascience, 2016
The venom of predatory marine cone snails mainly contains a diverse array of unique bioactive peptides commonly referred to as conopeptides or conotoxins. These peptides have proven to be valuable pharmacological probes and potential drugs because of their high specificity and affinity to important ion channels, receptors and transporters of the ...
Peng C, Yao G, Gao BM, Fan CX, Bian C, Wang J, Cao Y, Wen B, Zhu Y, Ruan Z, Zhao X, You X, Bai J, Li J, Lin Z, Zou S, Zhang X, Qiu Y, Chen J, Coon SL, Yang J, Chen JS, Shi Q.   +22 more
europepmc   +9 more sources

High-throughput prediction and characterization of antimicrobial peptides from multi-omics datasets of Chinese tubular cone snail (Conus betulinus)

Frontiers in Marine Science, 2022
Individual cone snail (Conus sp.) contains thousands of bioactive peptides, but there are limited studies on its antimicrobial peptides (AMPs). Here, we investigated AMPs along with AMP-derived genes in the representative Chinese tubular cone snail (C ...
Ruihan Li, Ruihan Li, Yu Huang, Chao Peng, Zijian Gao, Jie Liu, Xiaoting Yin, Xiaoting Yin, Xiaoting Yin, Bingmiao Gao, Tatiana V. Ovchinnikova, Limei Qiu, Limei Qiu, Chao Bian, Chao Bian, Qiong Shi, Qiong Shi   +16 more
doaj   +4 more sources

Screening and Validation of Highly-Efficient Insecticidal Conotoxins from a Transcriptome-Based Dataset of Chinese Tubular Cone Snail [PDF]

Toxins, 2017
Most previous studies have focused on analgesic and anti-cancer activities for the conotoxins identified from piscivorous and molluscivorous cone snails, but little attention has been devoted to insecticidal activity of conotoxins from the dominant ...
Bingmiao Gao, Chao Peng, Bo Lin, Qin Chen, Junqing Zhang, Qiong Shi   +5 more
doaj   +4 more sources

Systematic dissection of genomic features determining the vast diversity of conotoxins [PDF]

BMC Genomics, 2023
Background Conus, a highly diverse species of venomous predators, has attracted significant attention in neuroscience and new drug development due to their rich collection of neuroactive peptides called conotoxins.
Jian-Wei Zheng, Yang Lu, Yu-Feng Yang, Dan Huang, Da-Wei Li, Xiang Wang, Yang Gao, Wei-Dong Yang, Yuanfang Guan, Hong-Ye Li   +9 more
doaj   +2 more sources

Polypharmacological Cell-Penetrating Peptides from Venomous Marine Animals Based on Immunomodulating, Antimicrobial, and Anticancer Properties [PDF]

Marine Drugs, 2022
Complex pathological diseases, such as cancer, infection, and Alzheimer’s, need to be targeted by multipronged curative. Various omics technologies, with a high rate of data generation, demand artificial intelligence to translate these data into ...
Shiva Hemmati, Haniyeh Rasekhi Kazerooni
doaj   +2 more sources

Chromosome-level genome of the venomous snail Kalloconus canariensis: a valuable model for venomics and comparative genomics. [PDF]

Gigascience, 2022
BACKGROUND: Genomes are powerful resources to understand the evolutionary mechanisms underpinning the origin and diversification of the venoms of cone snails (Conidae: Caenogastropoda) and could aid in the development of novel drugs.
Herráez-Pérez A, Pardos-Blas JR, Afonso CML, Tenorio MJ, Zardoya R.   +4 more
europepmc   +3 more sources

Target‐capture probes for phylogenomics of the Caenogastropoda

Molecular Ecology Resources, Volume 23, Issue 6, Page 1372-1388, August 2023., 2023
Abstract Target‐capture approaches have facilitated a rapid growth in the field of phylogenomics but few probe sets exist for molluscs, an exceptionally rich phylum with unparalleled ecological and morphological diversity. We designed and tested the first universal probe set using Phyluce to capture ultraconserved elements (UCEs) and exon loci from the
Tricia C. Goulding, Ellen E. Strong, Andrea M. Quattrini   +2 more
wiley   +1 more source