Results 1 to 10 of about 24,889 (220)

Calcium channel modulation as a target in chronic pain control [PDF]

, 2017
Neuropathic pain remains poorly treated for large numbers of patients and little progress has been made in developing novel classes of analgesics. To redress this issue, ziconotide (PrialtTM ) was developed and approved as a first in class synthetic ...
Dickenson, AH, Montagut Bordas, C, Patel, RA   +2 more
core   +1 more source

In Vitro Effect of the Synthetic cal14.1a Conotoxin, Derived from Conus californicus, on the Human Parasite Toxoplasma gondii

Marine Drugs, 2016
Toxins that are secreted by cone snails are small peptides that are used to treat several diseases. However, their effects on parasites with human and veterinary significance are unknown.
Marco A. De León-Nava, Eunice Romero-Núñez, Angélica Luna-Nophal, Johanna Bernáldez-Sarabia, Liliana N. Sánchez-Campos, Alexei F. Licea-Navarro, Jorge Morales-Montor, Saé Muñiz-Hernández   +7 more
doaj   +1 more source

Stabilization of a-conotoxin AuIB: influences of disulfide connectivity and backbone cyclization [PDF]

, 2011
a-Conotoxins are peptides isolated from the venom ducts of cone snails that target nicotinic acetylcholine receptors (nAChRs). They are valuable pharmacological tools and have potential applications for treating a range of conditions in humans, including
Adams, DJ, Alvarmo, C, Clark, R, Craik, D, Daly, N, Grishin, A, Gunasekera, S, Lovelace, E, Nevin, S   +8 more
core  

A mouse model of autism implicates endosome pH in the regulation of presynaptic calcium entry. [PDF]

, 2018
Psychoactive compounds such as chloroquine and amphetamine act by dissipating the pH gradient across intracellular membranes, but the physiological mechanisms that normally regulate organelle pH remain poorly understood.
Bendor, Jacob, Edwards, Robert H, Levy, Jonathan, Nicoll, Roger A, Pham, Ellen, Seifikar, Helia, Silm, Katlin, Sohal, Vikaas S, Sullivan, Michael, Ullman, Julie C, Yang, Jing   +10 more
core   +3 more sources

A Transcriptomic Survey of Ion Channel-Based Conotoxins in the Chinese Tubular Cone Snail (Conus betulinus)

Marine Drugs, 2017
Conotoxins in the venom of cone snails (Conus spp.) are a mixture of active peptides that work as blockers, agonists, antagonists, or inactivators of various ion channels.
Yu Huang, Chao Peng, Yunhai Yi, Bingmiao Gao, Qiong Shi   +4 more
doaj   +1 more source

Novel conopeptides of the I-superfamily occur in several clades of cone snails [PDF]

, 2004
The I-superfamily of conotoxins represents a new class of peptides in the venom of some Conus species. These toxins are characterized by four disulfide bridges and inhibit or modify ion channels of nerve cells.
Huys, I., Kauferstein, S., Kuch, U., Mebs, D., Melaun, C., Tytgat, J.   +5 more
core   +1 more source

Structural Basis for α-Conotoxin Potency and Selectivity [PDF]

, 2009
Parkinson\u27s disease is a debilitating movement disorder characterized by altered levels of α6β2* nicotinic acetylcholine receptors (nAChRs) localized on presynaptic striatal catecholaminergic neurons.
Cornell, Kenneth A., Eidemiller, Seth, Marshall, Joshua, Martin, Bryan, McDougal, Owen M., McIntosh, J. Michael, Narver, Andrew, Turner, Matt, Zemp, Logan   +8 more
core   +2 more sources

Ablation of the N-type calcium channel ameliorates diabetic nephropathy with improved glycemic control and reduced blood pressure [PDF]

, 2016
Pharmacological blockade of the N-and L-type calcium channel lessens renal injury in kidney disease patients. The significance of specific blockade of α1 subunit of N-type calcium channel, Cav2.2, in diabetic nephropathy, however, remains to be clarified.
Fujikura, Junji, Imamaki, Hirotaka, Ishii, Akira, Kasahara, Masato, Kuwabara, Takashige, Kuwahara, Koichiro, Mori, Kiyoshi, Mori, Yasuo, Mukoyama, Masashi, Naito, Masaki, Nakao, Kazuwa, Numata, Tomohiro, Ohno, Shoko, Saleem, Moin, Yanagita, Motoko, Yokoi, Hideki   +15 more
core   +4 more sources

Ca2+ transients are not required as signals for long-term neurite outgrowth from cultured sympathetic neurons [PDF]

, 1990
A method for clamping cytosolic free Ca2+ ([Ca2+]i) in cultures of rat sympathetic neurons at or below resting levels for several days was devised to determine whether Ca2+ signals are required for neurite outgrowth from neurons that depend on Nerve ...
Murrell, R D, Suidan, H S, Tolkovsky, A M, Walker, A E   +3 more
core   +2 more sources

Cone Snails: A Big Store of Conotoxins for Novel Drug Discovery

Toxins, 2017
Marine drugs have developed rapidly in recent decades. Cone snails, a group of more than 700 species, have always been one of the focuses for new drug discovery.
Bingmiao Gao, Chao Peng, Jiaan Yang, Yunhai Yi, Junqing Zhang, Qiong Shi   +5 more
doaj   +1 more source