Results 1 to 10 of about 21,330 (214)
Conotoxin Gene Superfamilies [PDF]
Marine Drugs, 2014 Conotoxins are the peptidic components of the venoms of marine cone snails (genus Conus). They are remarkably diverse in terms of structure and function. Unique potency and selectivity profiles for a range of neuronal targets have made several conotoxins
Samuel D Robinson +2 more
exaly +10 more sources
In Silico Conotoxin Studies: Progress and Prospects [PDF]
MoleculesCone snails of the genus Conus have evolved to produce structurally distinct and functionally diverse venom peptides for defensive and predatory purposes.
Ruihan Li, Md. Mahadhi Hasan, Dan Wang
doaj +7 more sources
Recent Advances in Conotoxin Classification by Using Machine Learning Methods
Molecules, 2017 Conotoxins are disulfide-rich small peptides, which are invaluable peptides that target ion channel and neuronal receptors. Conotoxins have been demonstrated as potent pharmaceuticals in the treatment of a series of diseases, such as Alzheimer’s disease,
Fu-Ying Dao, Hui Yang, Wuritu Yang
exaly +4 more sources
Toxins, 2022 We isolated a new dimeric conotoxin with inhibitory activity against neuronal nicotinic acetylcholine receptors. Edman degradation and transcriptomic studies indicate a homodimeric conotoxin composed by two chains of 47 amino acid in length.
Ximena C. Rodriguez-Ruiz +4 more
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Isolation and structural identification of a new T1-conotoxin with unique disulfide connectivities derived from Conus bandanus [PDF]
Journal of Venomous Animals and Toxins including Tropical Diseases, 2020 Background: Conopeptides are neuropharmacological peptides derived from the venomous salivary glands of cone snails. Among 29 superfamilies based on conserved signal sequences, T-superfamily conotoxins, which belong to the smallest group, include four ...
Nguyen Bao +3 more
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Comparative Venomics of the Cryptic Cone Snail Species Virroconus ebraeus and Virroconus judaeus
Marine Drugs, 2022 The venom duct transcriptomes and proteomes of the cryptic cone snail species Virroconus ebraeus and Virroconus judaeus were obtained and compared.
José Ramón Pardos-Blas +3 more
doaj +1 more source
Proteomic analysis of Red Sea Conus taeniatus venom reveals potential biological applications
Journal of Venomous Animals and Toxins including Tropical Diseases, 2021 Background: Diverse and unique bioactive neurotoxins known as conopeptides or conotoxins are produced by venomous marine cone snails. Currently, these small and stable molecules are of great importance as research tools and platforms for discovering new ...
Maged M. A. Fouda +4 more
doaj +1 more source
Structural and Functional Characterization of Conotoxins from Conus achatinus Targeting NMDAR
Marine Drugs, 2020 Conotoxin-Ac1 and its variant conotoxin-Ac1-O6P, were isolated from the venom duct of Conus achatinus, a fish-hunting cone snail species collected in the Sea of Hainan, China. Conotoxin-Ac1 is linear peptide that contain 15 amino acids.
Xiujie Liu +5 more
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Molecular evolution and diversity of Conus peptide toxins, as revealed by gene structure and intron sequence analyses. [PDF]
PLoS ONE, 2013 Cone snails, which are predatory marine gastropods, produce a cocktail of venoms used for predation, defense and competition. The major venom component, conotoxin, has received significant attention because it is useful in neuroscience research, drug ...
Yun Wu +9 more
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Marine Drugs, 2021 Marine cone snails are predatory gastropods characterized by a well-developed venom apparatus and highly evolved hunting strategies that utilize toxins to paralyze prey and defend against predators.
Rajesh Rajaian Pushpabai +4 more
doaj +1 more source