Results 31 to 40 of about 22,310 (212)
Blockade of neuronal α7-nAChR by α-conotoxin ImI explained by computational scanning and energy calculations. [PDF]
PLoS Computational Biology, 2011 α-Conotoxins potently inhibit isoforms of nicotinic acetylcholine receptors (nAChRs), which are essential for neuronal and neuromuscular transmission.
Rilei Yu, David J Craik, Quentin Kaas
doaj +1 more source
Solution structure of α-conotoxin SI [PDF]
, 2000 The nuclear magnetic resonance solution structure of α-conotoxin SI has been determined at pH 4.2. The 36 lowest energy structures show that α-conotoxin SI exists in a single major solution conformation and is stabilized by six hydrogen bonds ...
Hargittai, Balazs +9 more
core +1 more source
Marine Drugs, 2023 Chronic pain is one of the most prevalent health problems worldwide. An alternative to suppress or alleviate chronic pain is the use of peptide drugs that block N-type Ca2+ channels (Cav2.2), such as ω-conotoxin MVIIA.
Xiufang Ding +9 more
doaj +1 more source
A new member of the gamma-conotoxin family, isolated from Conus princeps displays a novel molecular target [PDF]
, 2016 "A novel conotoxin, named as PiVIIA, was isolated from the venom of Conus princeps, a marine predatory cone snail collected in the Pacific Southern Coast of Mexico.
JOHANNA BERNALDEZ SARABIA
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Synthesis and Biological Activity of Novel α-Conotoxins Derived from Endemic Polynesian Cone Snails
Marine Drugs, 2023 α-Conotoxins are well-known probes for the characterization of the various subtypes of nicotinic acetylcholine receptors (nAChRs). Identifying new α-conotoxins with different pharmacological profiles can provide further insights into the physiological or
Yazid Mohamed Souf +8 more
doaj +1 more source
Conotoxin Patenting Trends in Academia and Industry
, 2022 Sea snails of the genus Conus produce toxins that have been the subjects of numerous studies, projects, publications, and patents over the years. Since Conus toxins were discovered in the 1960s, their biological activity has been thought to have high ...
Licea-Navarro, Alexei F. +5 more
core +1 more source
Characterisation of a Novel A-Superfamily Conotoxin [PDF]
Biomedicines, 2020 Conopeptides belonging to the A-superfamily from the venomous molluscs, Conus, are typically α-conotoxins. The α-conotoxins are of interest as therapeutic leads and pharmacological tools due to their selectivity and potency at nicotinic acetylcholine receptor (nAChR) subtypes.
David T. Wilson +6 more
openaire +6 more sources
Inhibition of Escherichia coli chemotaxis by omega-conotoxin, a calcium ion channel blocker [PDF]
, 1993 Escherichia coli chemotaxis was inhibited by omega-conotoxin, a calcium ion channel blocker. With Tris-EDTA-permeabilized cells, nanomolar levels of omega-conotoxin inhibited chemotaxis without loss of motility.
Tisa, Louis S. +2 more
core +1 more source
Journal of Genetic Engineering and BiotechnologyBackground: Venomous marine cone snails produce unique neurotoxins called conopeptides or conotoxins, which are valuable for research and drug discovery.
Mousa O. Germoush +9 more
doaj +1 more source
Toxins, 2015 The α9α10-nicotinic acetylcholine receptor (nAChR) has been implicated in pain and has been proposed to be a novel target for analgesics. However, the evidence to support the involvement of the α9α10-nAChR in pain is conflicted.
Sarasa A. Mohammadi +1 more
doaj +1 more source