Results 31 to 40 of about 21,330 (214)

Blockade of neuronal α7-nAChR by α-conotoxin ImI explained by computational scanning and energy calculations. [PDF]

PLoS Computational Biology, 2011
α-Conotoxins potently inhibit isoforms of nicotinic acetylcholine receptors (nAChRs), which are essential for neuronal and neuromuscular transmission.
Rilei Yu, David J Craik, Quentin Kaas
doaj   +1 more source

A new member of the gamma-conotoxin family, isolated from Conus princeps displays a novel molecular target [PDF]

, 2016
"A novel conotoxin, named as PiVIIA, was isolated from the venom of Conus princeps, a marine predatory cone snail collected in the Pacific Southern Coast of Mexico.
JOHANNA BERNALDEZ SARABIA
core   +1 more source

α-Synuclein oligomers slow down action potential firing and enhance dopamine release by increasing Cav2.2 currents in midbrain dopaminergic neurons. [PDF]

J Physiol
Abstract figure legend Left: the spontaneous quantal release of dopamine (DA) occurs at very low frequency in control conditions. Right: exogenous α‐synuclein potentiates Cav2.2 currents and DA release but drastically reduces the spontaneous firing rate of substantia nigra DA neurons.
Tomagra G, Battaglia A, Franchino C, Bonzano S, Picollo F, Chiantia G, de Iure A, Calabresi P, Picconi B, Carbone E, De Marchis S, Marcantoni A, Carabelli V.   +12 more
europepmc   +2 more sources

Self-Assembly Nanostructure of Myristoylated ω-Conotoxin MVIIA Increases the Duration of Efficacy and Reduces Side Effects

Marine Drugs, 2023
Chronic pain is one of the most prevalent health problems worldwide. An alternative to suppress or alleviate chronic pain is the use of peptide drugs that block N-type Ca2+ channels (Cav2.2), such as ω-conotoxin MVIIA.
Xiufang Ding, Yue Wang, Sida Zhang, Ruihua Zhang, Dong Chen, Long Chen, Yu Zhang, Shi-Zhong Luo, Jianfu Xu, Chengxin Pei   +9 more
doaj   +1 more source

Synthesis and Biological Activity of Novel α-Conotoxins Derived from Endemic Polynesian Cone Snails

Marine Drugs, 2023
α-Conotoxins are well-known probes for the characterization of the various subtypes of nicotinic acetylcholine receptors (nAChRs). Identifying new α-conotoxins with different pharmacological profiles can provide further insights into the physiological or
Yazid Mohamed Souf, Gonxhe Lokaj, Veeresh Kuruva, Yakop Saed, Delphine Raviglione, Ashraf Brik, Annette Nicke, Nicolas Inguimbert, Sébastien Dutertre   +8 more
doaj   +1 more source

The A-superfamily of Conotoxins [PDF]

Journal of Biological Chemistry, 2004
The generation of functional novelty in proteins encoded by a gene superfamily is seldom well documented. In this report, we define the A-conotoxin superfamily, which is widely expressed in venoms of the predatory cone snails (Conus), and show how gene products that diverge considerably in structure and function have arisen within the same superfamily.
Ameurfina D. Santos, J. Michael McIntosh, David R. Hillyard, Lourdes J. Cruz, Baldomero M. Olivera   +4 more
openaire   +1 more source

Conotoxin Patenting Trends in Academia and Industry

, 2022
Sea snails of the genus Conus produce toxins that have been the subjects of numerous studies, projects, publications, and patents over the years. Since Conus toxins were discovered in the 1960s, their biological activity has been thought to have high ...
Licea-Navarro, Alexei F., Sanchez-Campos, Noemi, Johanna Bernaldez-Sarabia, Alexei F. Licea-Navarro, Noemi Sanchez-Campos, Bernaldez-Sarabia, Johanna   +5 more
core   +1 more source

AChBP-targeted alpha-conotoxin correlates distinct binding orientations with nAChR subtype selectivity

, 2007
Neuronal nAChRs are a diverse family of pentameric ion channels with wide distribution throughout cells of the nervous and immune systems. However, the role of specific subtypes in normal and pathological states remains poorly understood due to the lack ...
Sixma, Titia K., Alewood, Paul F., Buettner, Regina, van Elk, R, Smit, A.B., Sixma, T., Dutertre, S., Nicke, A, van Elk, R., Smit, A., Nicke, Annette, Alewood, P. F., Sixma, T.K., Kendel, Y., Smit, AB, Lewis, R. J., Hopping, G., Kendel, Y, van Elk, René, Büttner, Regina, Elk, René van, Ulens, C, Ulens, Chris, Buttner, R, Kendel, Yvonne, Sixma, TK, Fish, Alexander, Lewis, R.J., Schroeder, Christina, Lewis, Richard,, Smit, August,, Buttner, R., Elk, R. van, Alewood, P.F., Lewis, Richard J., Fish, A, Sixma, Titia,, Schroeder, C., Alewood, Paul,, Fish, A., Alewood, P., Dutertre, Sébastien, Smit, August B., Ulens, C., Hopping, Gene, Nicke, A., Lewis, R.   +46 more
core   +1 more source

Discovery and characterization of the short κA-conotoxins: A novel subfamily of excitatory conotoxins [PDF]

Toxicon, 2007
We have characterized the defining members of a novel subfamily of excitatory conotoxins, the short kappaA-conotoxins (kappaA(S)-conotoxins). kappaA-conotoxins PIVE and PIVF (kappaA-PIVE and kappaA-PIVF) were purified from Conus purpurascens venom. Both peptides elicited excitatory activity upon injection into fish.
Russell W, Teichert, Richard, Jacobsen, Heinrich, Terlau, Doju, Yoshikami, Baldomero M, Olivera   +4 more
openaire   +2 more sources

Proteomic analysis of the venom of Conus flavidus from Red Sea reveals potential pharmacological applications

Journal of Genetic Engineering and Biotechnology
Background: Venomous marine cone snails produce unique neurotoxins called conopeptides or conotoxins, which are valuable for research and drug discovery.
Mousa O. Germoush, Maged Fouda, Hamdy Aly, Islam Saber, Barakat M. Alrashdi, Diaa Massoud, Sarah Alzwain, Ahmed E. Altyar, Mohamed M. Abdel-Daim, Moustafa Sarhan   +9 more
doaj   +1 more source