Single-Disulfide Conopeptide Czon1107, an Allosteric Antagonist of the Human α3β4 Nicotinic Acetylcholine Receptor [PDF]
Marine Drugs, 2022 Conopeptides are peptides in the venom of marine cone snails that are used for capturing prey or as a defense against predators. A new cysteine-poor conopeptide, Czon1107, has exhibited non-competitive inhibition with an undefined allosteric mechanism in
Rilei Yu, Han-Shen Tae, David J. Adams
exaly +5 more sources
The Conopeptide αD-FrXXA, an Inhibitor of Voltage-Gated Potassium Channels [PDF]
Marine DrugsThe conopeptide αD-FrXXA was previously isolated by our team from the venom of the vermivorous snail Conus fergusoni. This toxin is composed of two chains of 47 amino acids and inhibits neuronal and muscular subtypes of nAChR.
Estuardo López-Vera
exaly +5 more sources
Bibliometric Review of the Literature on Cone Snail Peptide Toxins from 2000 to 2022 [PDF]
Marine Drugs, 2023 The venom of marine cone snails is mainly composed of peptide toxins called conopeptides, among which conotoxins represent those that are disulfide-rich.
Linh T. T. Nguyen +2 more
doaj +3 more sources
Usage of Cell-Free Protein Synthesis in Post-Translational Modification of μ-Conopeptide PIIIA [PDF]
Marine Drugs, 2023 The post-translational modifications of conopeptides are the most complicated modifications to date and are well-known and closely related to the activity of conopeptides.
Fanghui Wu, Yifeng Yin
exaly +4 more sources
Marine Drugs, 2014 A novel conotoxin (conopeptide) was biochemically characterized from the crude venom of the molluscivorous marine snail, Conus bandanus (Hwass in Bruguière, 1792), collected in the south-central coast of Vietnam.
Evelyne Benoit, Robert Thai
exaly +4 more sources
High-Throughput Prediction and Design of Novel Conopeptides for Biomedical Research and Development [PDF]
BioDesign Research, 2022 Cone snail venoms have been considered a valuable treasure for international scientists and businessmen, mainly due to their pharmacological applications in development of marine drugs for treatment of various human diseases.
Bingmiao Gao +7 more
doaj +2 more sources
Identification of Novel Conotoxin Precursors from the Cone Snail Conus spurius by High-Throughput RNA Sequencing [PDF]
Marine Drugs, 2021 Marine gastropods of the genus Conus, comprising more than 800 species, have the characteristic of injecting worms and other prey with venom. These conopeptide toxins, highly diverse in structure and action, are highly potent and specific for their ...
Roberto Zamora-Bustillos +4 more
doaj +2 more sources
The first Conus genome assembly reveals a primary genetic central dogma of conopeptides in C. betulinus [PDF]
Cell Discovery, 2021 Although there are various Conus species with publicly available transcriptome and proteome data, no genome assembly has been reported yet. Here, using Chinese tubular cone snail (C.
Chao Peng +24 more
doaj +2 more sources
Analgesic effect of recombinant GABAergic precursors releasing ω-conotoxin MVIIA in a model of peripheral nerve injury in rats [PDF]
Molecular Pain, 2022 Development of chronic pain has been attributed to dysfunctional GABA signaling in the spinal cord. Direct pharmacological interventions on GABA signaling are usually not very efficient and often accompanied by side effects due to the widespread ...
Stanislava Jergova +2 more
doaj +2 more sources
Deep learning-driven discovery and mechanism of action study of a minimalist conopeptide targeting α7 nicotinic acetylcholine receptor [PDF]
Acta Pharmaceutica Sinica BDespite extensive structural and functional characterization of the α7 nicotinic acetylcholine receptor, valuable structural insights into its interactions with conopeptides remain limited, thereby hindering the rational development of peptide-based ...
Jinghui Zhang +9 more
doaj +2 more sources