Single-Disulfide Conopeptide Czon1107, an Allosteric Antagonist of the Human α3β4 Nicotinic Acetylcholine Receptor [PDF]
Marine Drugs, 2022 Conopeptides are peptides in the venom of marine cone snails that are used for capturing prey or as a defense against predators. A new cysteine-poor conopeptide, Czon1107, has exhibited non-competitive inhibition with an undefined allosteric mechanism in
David J. Adams, Tao Jiang, Han-Shen Tae
exaly +4 more sources
Bibliometric Review of the Literature on Cone Snail Peptide Toxins from 2000 to 2022 [PDF]
Marine Drugs, 2023 The venom of marine cone snails is mainly composed of peptide toxins called conopeptides, among which conotoxins represent those that are disulfide-rich.
Linh T. T. Nguyen +2 more
doaj +2 more sources
Usage of Cell-Free Protein Synthesis in Post-Translational Modification of μ-Conopeptide PIIIA [PDF]
Marine Drugs, 2023 The post-translational modifications of conopeptides are the most complicated modifications to date and are well-known and closely related to the activity of conopeptides.
Yanli Liu +5 more
doaj +2 more sources
High-Throughput Prediction and Design of Novel Conopeptides for Biomedical Research and Development [PDF]
BioDesign Research, 2022 Cone snail venoms have been considered a valuable treasure for international scientists and businessmen, mainly due to their pharmacological applications in development of marine drugs for treatment of various human diseases.
Bingmiao Gao +7 more
doaj +2 more sources
The Conopeptide αD-FrXXA, an Inhibitor of Voltage-Gated Potassium Channels [PDF]
Marine DrugsThe conopeptide αD-FrXXA was previously isolated by our team from the venom of the vermivorous snail Conus fergusoni. This toxin is composed of two chains of 47 amino acids and inhibits neuronal and muscular subtypes of nAChR.
Luis Martínez-Hernández +3 more
doaj +2 more sources
Identification of Novel Conotoxin Precursors from the Cone Snail Conus spurius by High-Throughput RNA Sequencing [PDF]
Marine Drugs, 2021 Marine gastropods of the genus Conus, comprising more than 800 species, have the characteristic of injecting worms and other prey with venom. These conopeptide toxins, highly diverse in structure and action, are highly potent and specific for their ...
Roberto Zamora-Bustillos +4 more
doaj +2 more sources
The first Conus genome assembly reveals a primary genetic central dogma of conopeptides in C. betulinus [PDF]
Cell Discovery, 2021 Although there are various Conus species with publicly available transcriptome and proteome data, no genome assembly has been reported yet. Here, using Chinese tubular cone snail (C.
Chao Peng +24 more
doaj +2 more sources
Analgesic effect of recombinant GABAergic precursors releasing ω-conotoxin MVIIA in a model of peripheral nerve injury in rats [PDF]
Molecular Pain, 2022 Development of chronic pain has been attributed to dysfunctional GABA signaling in the spinal cord. Direct pharmacological interventions on GABA signaling are usually not very efficient and often accompanied by side effects due to the widespread ...
Stanislava Jergova +2 more
doaj +2 more sources
Identification of Conomarphin Variants in the Conus eburneus Venom and the Effect of Sequence and PTM Variations on Conomarphin Conformations [PDF]
Marine Drugs, 2020 Marine cone snails belonging to the Conidae family make use of neuroactive peptides in their venom to capture prey. Here we report the proteome profile of the venom duct of Conus eburneus, a cone snail belonging to the Tesseliconus clade.
Corazon Ericka Mae M. Itang +6 more
doaj +2 more sources
Conotoxin Patenting Trends in Academia and Industry [PDF]
Marine Drugs, 2022 Sea snails of the genus Conus produce toxins that have been the subjects of numerous studies, projects, publications, and patents over the years. Since Conus toxins were discovered in the 1960s, their biological activity has been thought to have high ...
Noemi Sanchez-Campos +2 more
doaj +2 more sources