Results 11 to 20 of about 1,087 (186)
Conopeptides from Cape Verde Conus crotchii [PDF]
Marine Drugs, 2013 Marine Cone snails of the genus Conus contain complex peptide toxins in their venom. Living in tropical habitats, they usually use the powerful venom for self-defense and prey capture.
Agostinho Antunes +4 more
doaj +6 more sources
Transcriptomic Analysis of Marine Gastropod Hemifusus tuba Provides Novel Insights into Conotoxin Genes [PDF]
Marine Drugs, 2019 The marine gastropod Hemifusus tuba is served as a luxury food in Asian countries and used in traditional Chinese medicine to treat lumbago and deafness. The lack of genomic data on H.
Ronghua Li +6 more
doaj +6 more sources
Molecular Phylogeny, Classification and Evolution of Conopeptides [PDF]
Journal of Molecular Evolution, 2018 Conopeptides are toxins expressed in the venom duct of cone snails (Conoidea, Conus). These are mostly well-structured peptides and mini-proteins with high potency and selectivity for a broad range of cellular targets.
Favreau, P. +4 more
core +6 more sources
Advanced ScienceThe δ‐conotoxins, a class of peptides produced in the venom of cone snails, are of interest due to their ability to inhibit the inactivation of voltage‐gated sodium channels causing paralysis and other neurological responses, but difficulties in their ...
Stephen McCarthy, Shane Gonen
doaj +2 more sources
Marine Drugs, 2014 A novel conotoxin (conopeptide) was biochemically characterized from the crude venom of the molluscivorous marine snail, Conus bandanus (Hwass in Bruguière, 1792), collected in the south-central coast of Vietnam.
Robert Thai +2 more
exaly +3 more sources
High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain. [PDF]
PLoS ONE, 2007 Little is known about the molecular basis of somatosensory mechanotransduction in mammals. We screened a library of peptide toxins for effects on mechanically activated currents in cultured dorsal root ganglion neurons.
Liam J Drew +11 more
doaj +3 more sources
Novel Conopeptides of Largely Unexplored Indo Pacific Conus sp. [PDF]
Marine Drugs, 2016 Cone snails are predatory creatures using venom as a weapon for prey capture and defense. Since this venom is neurotoxic, the venom gland is considered as an enormous collection of pharmacologically interesting compounds having a broad spectrum of ...
Eline K. M. Lebbe +9 more
doaj +3 more sources
ConoServer: updated content, knowledge, and discovery tools in the conopeptide database [PDF]
Nucleic Acids Research, 2011 International audienceConoServer (http://www.conoserver.org) is a database specializing in the sequences and structures of conopeptides, which are toxins expressed by marine cone snails. Cone snails are carnivorous gastropods, which hunt their prey using
Kaas, Quentin +4 more
core +4 more sources
Side-chain dynamics of the α1B -adrenergic receptor determined by NMR via methyl relaxation. [PDF]
Protein Sci, 2023 Abstract G protein‐coupled receptors (GPCRs) are medically important membrane proteins that sample inactive, intermediate, and active conformational states characterized by relatively slow interconversions (~μs–ms). On a faster timescale (~ps–ns), the conformational landscape of GPCRs is governed by the rapid dynamics of amino acid side chains.
Baumann C +8 more
europepmc +2 more sources
Improved prediction of conopeptide superfamilies with ConoDictor 2.0. [PDF]
Bioinform Adv, 2021 Abstract Motivation Cone snails are among the richest sources of natural peptides with promising pharmacological and therapeutic applications. With the reduced costs of RNAseq, scientists now heavily rely on venom gland transcriptomes for the mining of novel bioactive conopeptides, but the ...
Koua D, Ebou A, Dutertre S.
europepmc +3 more sources