Results 11 to 20 of about 771 (173)
Advanced ScienceThe δ‐conotoxins, a class of peptides produced in the venom of cone snails, are of interest due to their ability to inhibit the inactivation of voltage‐gated sodium channels causing paralysis and other neurological responses, but difficulties in their ...
Stephen McCarthy, Shane Gonen
doaj +2 more sources
Conotoxin Patenting Trends in Academia and Industry [PDF]
Marine Drugs, 2022 Sea snails of the genus Conus produce toxins that have been the subjects of numerous studies, projects, publications, and patents over the years. Since Conus toxins were discovered in the 1960s, their biological activity has been thought to have high ...
Noemi Sanchez-Campos +2 more
doaj +2 more sources
Conopeptides from Cape Verde Conus crotchii [PDF]
Marine Drugs, 2013 Marine Cone snails of the genus Conus contain complex peptide toxins in their venom. Living in tropical habitats, they usually use the powerful venom for self-defense and prey capture.
Agostinho Antunes +4 more
doaj +3 more sources
High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain. [PDF]
PLoS ONE, 2007 Little is known about the molecular basis of somatosensory mechanotransduction in mammals. We screened a library of peptide toxins for effects on mechanically activated currents in cultured dorsal root ganglion neurons.
Liam J Drew +11 more
doaj +3 more sources
Transcriptomic Analysis of Marine Gastropod Hemifusus tuba Provides Novel Insights into Conotoxin Genes [PDF]
Marine Drugs, 2019 The marine gastropod Hemifusus tuba is served as a luxury food in Asian countries and used in traditional Chinese medicine to treat lumbago and deafness. The lack of genomic data on H.
Ronghua Li +6 more
doaj +2 more sources
Towards an integrated venomics approach for accelerated conopeptide discovery
Toxicon, 2012 Conopeptides and conotoxins are small peptides produced by cone snails as a part of their predatory/defense strategies that target key ion channels and receptors in the nervous system. Some of these peptides also potently target mammalian ion channels involved in pain pathways.
Jutty Rajan, Prashanth +2 more
openaire +6 more sources
κO-SrVIA Conopeptide, a Novel Inhibitor Peptide for Two Members of the Human EAG Potassium Channel Family. [PDF]
Int J Mol Sci, 2023 The first conotoxin affecting the voltage-gated potassium channels of the EAG family was identified and characterized from the venom of the vermivorous species Conus spurius from the Gulf of Mexico.
Martínez-Hernández L +4 more
europepmc +2 more sources
Discovery and development of the χ-conopeptide class of analgesic peptides
Toxicon, 2012 Cone snail venoms continue to provide a rich source of bioactive peptides useful as research tools and leads to new therapeutics. We isolated two closely related conopeptides, MrIA and MrIB, which defined the χ-conopeptide class of bioactive peptides based on their unique ability to highly selectively and non-competitively inhibit the norepinephrine ...
Lewis, Richard J., Richard J. Lewis
openaire +6 more sources
Conopeptides as novel options for pain management
Drugs of the Future, 2011 Conopeptides are the peptidic components of the venoms of marine cone snails from the Conus genus. Aside from their natural function in pharmacologically immobilizing prey, they have attracted the attention of drug designers in recent years because of their potency and selectivity at a range of pharmaceutically important targets in mammals, including ...
Daly, N. L., Craik, David J.
openaire +5 more sources
Side-chain dynamics of the α1B -adrenergic receptor determined by NMR via methyl relaxation. [PDF]
Protein Sci, 2023 Abstract G protein‐coupled receptors (GPCRs) are medically important membrane proteins that sample inactive, intermediate, and active conformational states characterized by relatively slow interconversions (~μs–ms). On a faster timescale (~ps–ns), the conformational landscape of GPCRs is governed by the rapid dynamics of amino acid side chains.
Baumann C +8 more
europepmc +2 more sources