Results 11 to 20 of about 467 (80)
International Journal of Peptides, Volume 2013, Issue 1, 2013., 2013 Conus venoms are rich sources of biologically active peptides that act specifically on ionic channels and metabotropic receptors present at the neuromuscular junction, efficiently paralyzing the prey. Each species of Conus may have 50 to 200 uncharacterized bioactive peptides with pharmacological interest.
Maria Cristina Vianna Braga +6 more
wiley +1 more source
A Benchmark Dataset Comprising Partition and Distribution Coefficients of Linear Peptides
Dataset Papers in Science, Volume 2013, Issue 1, 2013., 2013 Peptides have a dominant role in biology; yet the study of their physical properties is at best sporadic. Peptide quantitative structure‐activity relationship (QSAR) lags far behind the QSAR analysis of drug‐like organic small molecules. Traditionally, QSAR has focussed on experimentally determined partition coefficients as the main descriptor of ...
Matthew N. Davies +3 more
wiley +1 more source
British Journal of Pharmacology, Volume 182, Issue 3, Page 564-580, February 2025.Abstract Background and Purpose Botulinum neurotoxin type A1 (BoNT/A) is one of the most potent neurotoxins known. At the same time, it is also one of the safest therapeutic agents used for the treatment of several human disorders and in aesthetic medicine.
Mickaël Machicoane +9 more
wiley +1 more source
[Retracted] A Showcase of Bench‐to‐Bedside Regenerative Medicine at the 2010 ASNTR
The Scientific World Journal, Volume 11, Issue 1, Page 1842-1864, 2011., 2011 Insight into the expanding themes of regenerative medicine is provided by the American Society for Neural Therapy and Repair′s annual meeting. The 17th meeting covered a wide range of neurodegenerative disorders, exploring methods to elucidate the currently unknown mechanisms behind the disorders, as well as possible treatments ranging from the use of ...
David J. Eve +3 more
wiley +1 more source
Prey specificity of predatory venoms
Biological Reviews, Volume 99, Issue 6, Page 2253-2273, December 2024.ABSTRACT Venom represents a key adaptation of many venomous predators, allowing them to immobilise prey quickly through chemical rather than physical warfare. Evolutionary arms races between prey and a predator are believed to be the main factor influencing the potency and composition of predatory venoms.
Ondřej Michálek +2 more
wiley +1 more source
Journal of Peptide Science, Volume 30, Issue 11, November 2024.This review provides an overview of FDA‐approved peptides, particularly those targeting cardiovascular diseases, human immunodeficiency, and central nervous system diseases, and also addresses conditions such as osteoporosis, thrombocytopenia, Cushing's disease, and hypoglycemia.
Othman Al Musaimi
wiley +1 more source
Advanced Science, Volume 11, Issue 35, September 18, 2024.δ‐Conotoxins are a diverse class of peptides that inhibit the inactivation of voltage‐gated sodium channels – proteins implicated in many human diseases – but which remain poorly characterized. Computational modeling of 18 different δ‐conotoxins using traditional and deep learning techniques uncovers structural features underlying the varying ...
Stephen McCarthy, Shane Gonen
wiley +1 more source
The FASEB Journal, Volume 38, Issue 1, 15 January 2024.Analogs of α‐conotoxin PnIC selectively inhibit α7β2‐ over α7‐only subtype nicotinic acetylcholine receptors via a novel allosteric mechanism.Andrew A. George, Sabin J. John, Linda M. Lucero, J. Brek Eaton, Ekta Jaiswal, Sean B. Christensen, Joanna Gajewiak, Maren Watkins, Yiwei Cao, Baldomero M. Olivera, Wonpil Im, J.
Andrew A. George +12 more
wiley +1 more source
Bibliometric Review of the Literature on Cone Snail Peptide Toxins from 2000 to 2022. [PDF]
Mar Drugs, 2023 Nguyen LTT, Craik DJ, Kaas Q.
europepmc +1 more source
High-Throughput Prediction and Design of Novel Conopeptides for Biomedical Research and Development. [PDF]
Biodes Res, 2022 Gao B +7 more
europepmc +1 more source