An Orthogonal Protection Strategy for the Synthesis of Conotoxins Containing Three Disulfide Bonds [PDF]
Marine DrugsDisulfide bonds are crucial for stabilizing bioactive peptides such as conotoxins. We have developed a method for synthesizing conotoxins with three disulfide bonds using Mob, Trt, and Acm protection groups for regionally selective synthesis.
Lai Yue Chan, David J Craik, Rilei Yu
exaly +4 more sources
Machine Learning Framework for Conotoxin Class and Molecular Target Prediction [PDF]
ToxinsConotoxins are small and highly potent neurotoxic peptides derived from the venom of marine cone snails which have captured the interest of the scientific community due to their pharmacological potential.
Duc P. Truong +3 more
doaj +2 more sources
Residues Responsible for the Selectivity of α-Conotoxins for Ac-AChBP or nAChRs
Marine Drugs, 2016 Nicotinic acetylcholine receptors (nAChRs) are targets for developing new drugs to treat severe pain, nicotine addiction, Alzheimer disease, epilepsy, etc. α-Conotoxins are biologically and chemically diverse. With 12–19 residues and two disulfides, they
Bo Lin, Mengsen Li
exaly +3 more sources
ConoGPT: Fine-Tuning a Protein Language Model by Incorporating Disulfide Bond Information for Conotoxin Sequence Generation [PDF]
ToxinsConotoxins are a class of peptide toxins secreted by marine mollusks of the Conus genus, characterized by their unique mechanism of action and significant biological activity, making them highly valuable for drug development. However, traditional methods
Guohui Zhao +4 more
doaj +2 more sources
Preclinical Efficacy and Proteomic Prediction of Molecular Targets for s-cal14.1b and s-cal14.2b Conotoxins with Antitumor Capacity in Xenografts of Malignant Pleural Mesothelioma [PDF]
Marine DrugsMalignant pleural mesothelioma (MPM) is a rare neoplasm with increasing incidence and mortality rates. Although recent advances have improved the overall prognosis, they have not had an important impact on survival of patients with MPM, such that more ...
Angélica Luna-Nophal +12 more
doaj +2 more sources
Voltage-Gated Sodium Channel Inhibition by µ-Conotoxins [PDF]
Toxinsµ-Conotoxins are small, potent pore-blocker inhibitors of voltage-gated sodium (NaV) channels, which have been identified as pharmacological probes and putative leads for analgesic development.
Kirsten L. McMahon +2 more
doaj +2 more sources
Chemical Synthesis and Insecticidal Activity Research Based on α-Conotoxins [PDF]
MoleculesThe escalating resistance of agricultural pests to chemical insecticides necessitates the development of novel, efficient, and safe biological insecticides.
Chengzhang Lin +4 more
doaj +2 more sources
Predatory and Defensive Strategies in Cone Snails [PDF]
ToxinsCone snails are carnivorous marine animals that prey on fish (piscivorous), worms (vermivorous), or other mollusks (molluscivorous). They produce a complex venom mostly made of disulfide-rich conotoxins and conopeptides in a compartmentalized venom gland.
Zahrmina Ratibou +2 more
doaj +2 more sources
Frontiers in Marine Science, 2022 Marine cone snail venoms represent a vast library of bioactive peptides with proven potential as research tools, drug leads, and therapeutics. In this study, a transcriptome library of four different organs, namely radular sheath, venom duct, venom gland,
Yanling Liao +8 more
doaj +1 more source
Asian Pacific Journal of Tropical Biomedicine, 2020 Objective: To determine the new M-superfamily conotoxins from molluscivorous snail Conus bandanus in Vietnam. Methods: Conus bandanus venom was fractionated and purified on HPLC system with an analytical reversed-phase C18 column in order to screen small
Nguyen Bao +2 more
doaj +1 more source