An Orthogonal Protection Strategy for the Synthesis of Conotoxins Containing Three Disulfide Bonds [PDF]
Marine DrugsDisulfide bonds are crucial for stabilizing bioactive peptides such as conotoxins. We have developed a method for synthesizing conotoxins with three disulfide bonds using Mob, Trt, and Acm protection groups for regionally selective synthesis.
Lai Yue Chan, David Craik, Ri-lei Yu
exaly +4 more sources
Machine Learning Framework for Conotoxin Class and Molecular Target Prediction. [PDF]
Toxins (Basel)Conotoxins are small and highly potent neurotoxic peptides derived from the venom of marine cone snails which have captured the interest of the scientific community due to their pharmacological potential.
Truong DP +3 more
europepmc +2 more sources
ConoGPT: Fine-Tuning a Protein Language Model by Incorporating Disulfide Bond Information for Conotoxin Sequence Generation. [PDF]
Toxins (Basel)Conotoxins are a class of peptide toxins secreted by marine mollusks of the Conus genus, characterized by their unique mechanism of action and significant biological activity, making them highly valuable for drug development. However, traditional methods
Zhao G, Ge C, Han W, Yu R, Liu H.
europepmc +2 more sources
Residues Responsible for the Selectivity of α-Conotoxins for Ac-AChBP or nAChRs
Marine Drugs, 2016 Nicotinic acetylcholine receptors (nAChRs) are targets for developing new drugs to treat severe pain, nicotine addiction, Alzheimer disease, epilepsy, etc. α-Conotoxins are biologically and chemically diverse. With 12–19 residues and two disulfides, they
Bo Lin, Mengsen Li
exaly +3 more sources
Preclinical Efficacy and Proteomic Prediction of Molecular Targets for s-cal14.1b and s-cal14.2b Conotoxins with Antitumor Capacity in Xenografts of Malignant Pleural Mesothelioma. [PDF]
Mar DrugsMalignant pleural mesothelioma (MPM) is a rare neoplasm with increasing incidence and mortality rates. Although recent advances have improved the overall prognosis, they have not had an important impact on survival of patients with MPM, such that more ...
Luna-Nophal A +12 more
europepmc +2 more sources
Marine Drugs, 2018 α-Conotoxins from Conus snails are capable of distinguishing muscle and neuronal nicotinic acetylcholine receptors (nAChRs). α-Conotoxin RgIA and αO-conotoxin GeXIVA, blocking neuronal α9α10 nAChR, are potential analgesics ...
Marios Zouridakis +2 more
exaly +3 more sources
Surface-Imprinted Acrylamide Polymer-Based Reduced Graphene-Gold Sensor in Rapid and Sensitive Electrochemical Determination of αB-Conotoxin. [PDF]
Sensors (Basel)The quantitative determination of conotoxins has great potential in the development of natural marine peptide pharmaceuticals. Considering the time-consuming sample pretreatment and expensive equipment in MS or LC-MS/MS analysis, an electrochemical ...
Cao J, Li J, Yu T, Wang F.
europepmc +2 more sources
Peptide Toxins from Marine <i>Conus</i> Snails with Activity on Potassium Channels and/or Currents. [PDF]
Toxins (Basel)Toxins from Conus snails are peptides characterized by a great structural and functional diversity. They have a high affinity for a wide range of membrane proteins such as ion channels, neurotransmitter transporters, and G protein-coupled receptors ...
Martínez-Hernández L +2 more
europepmc +2 more sources
Voltage-Gated Sodium Channel Inhibition by µ-Conotoxins. [PDF]
Toxins (Basel)µ-Conotoxins are small, potent pore-blocker inhibitors of voltage-gated sodium (NaV) channels, which have been identified as pharmacological probes and putative leads for analgesic development.
McMahon KL, Vetter I, Schroeder CI.
europepmc +2 more sources
Chemical Synthesis and Insecticidal Activity Research Based on α-Conotoxins [PDF]
MoleculesThe escalating resistance of agricultural pests to chemical insecticides necessitates the development of novel, efficient, and safe biological insecticides.
Chengzhang Lin +4 more
europepmc +2 more sources