An Orthogonal Protection Strategy for the Synthesis of Conotoxins Containing Three Disulfide Bonds [PDF]
Marine DrugsDisulfide bonds are crucial for stabilizing bioactive peptides such as conotoxins. We have developed a method for synthesizing conotoxins with three disulfide bonds using Mob, Trt, and Acm protection groups for regionally selective synthesis.
Rilei Yu, Lai Yue Chan, David Craik
exaly +4 more sources
Chemical Synthesis and Insecticidal Activity Research Based on α-Conotoxins [PDF]
MoleculesThe escalating resistance of agricultural pests to chemical insecticides necessitates the development of novel, efficient, and safe biological insecticides.
Chengzhang Lin +4 more
doaj +3 more sources
Residues Responsible for the Selectivity of α-Conotoxins for Ac-AChBP or nAChRs
Marine Drugs, 2016 Nicotinic acetylcholine receptors (nAChRs) are targets for developing new drugs to treat severe pain, nicotine addiction, Alzheimer disease, epilepsy, etc. α-Conotoxins are biologically and chemically diverse. With 12–19 residues and two disulfides, they
Bo Lin, Mengsen Li
exaly +3 more sources
Machine Learning Framework for Conotoxin Class and Molecular Target Prediction [PDF]
ToxinsConotoxins are small and highly potent neurotoxic peptides derived from the venom of marine cone snails which have captured the interest of the scientific community due to their pharmacological potential.
Duc P. Truong +3 more
doaj +2 more sources
ConoGPT: Fine-Tuning a Protein Language Model by Incorporating Disulfide Bond Information for Conotoxin Sequence Generation [PDF]
ToxinsConotoxins are a class of peptide toxins secreted by marine mollusks of the Conus genus, characterized by their unique mechanism of action and significant biological activity, making them highly valuable for drug development. However, traditional methods
Guohui Zhao +4 more
doaj +2 more sources
Preclinical Efficacy and Proteomic Prediction of Molecular Targets for s-cal14.1b and s-cal14.2b Conotoxins with Antitumor Capacity in Xenografts of Malignant Pleural Mesothelioma [PDF]
Marine DrugsMalignant pleural mesothelioma (MPM) is a rare neoplasm with increasing incidence and mortality rates. Although recent advances have improved the overall prognosis, they have not had an important impact on survival of patients with MPM, such that more ...
Angélica Luna-Nophal +12 more
doaj +2 more sources
Frontiers in Marine Science, 2022 Marine cone snail venoms represent a vast library of bioactive peptides with proven potential as research tools, drug leads, and therapeutics. In this study, a transcriptome library of four different organs, namely radular sheath, venom duct, venom gland,
Yanling Liao +8 more
doaj +1 more source
Asian Pacific Journal of Tropical Biomedicine, 2020 Objective: To determine the new M-superfamily conotoxins from molluscivorous snail Conus bandanus in Vietnam. Methods: Conus bandanus venom was fractionated and purified on HPLC system with an analytical reversed-phase C18 column in order to screen small
Nguyen Bao +2 more
doaj +1 more source
Characterisation of a Novel A-Superfamily Conotoxin
Biomedicines, 2020 Conopeptides belonging to the A-superfamily from the venomous molluscs, Conus, are typically α-conotoxins. The α-conotoxins are of interest as therapeutic leads and pharmacological tools due to their selectivity and potency at nicotinic acetylcholine ...
David T. Wilson +6 more
doaj +1 more source
Venom duct origins of prey capture and defensive conotoxins in piscivorous Conus striatus
Scientific Reports, 2021 The venom duct origins of predatory and defensive venoms has not been studied for hook-and-line fish hunting cone snails despite the pharmacological importance of their venoms. To better understand the biochemistry and evolution of injected predatory and
S. W. A. Himaya +5 more
doaj +1 more source