Fingerprint Analysis and Comparison of Activity Differences of Crude Venom from Five Species of Vermivorous Cone Snail in the South China Sea [PDF]
Marine DrugsThe South China Sea is rich in cone snail resources, known for producing conotoxins with diverse biological activities such as analgesic, anticancer, and insecticidal effects.
Yanling Liao, Jinxing Fu, Kailin Mao
exaly +5 more sources
Non-Peptidic Small Molecule Components from Cone Snail Venoms [PDF]
Frontiers in Pharmacology, 2021 Venomous molluscs (Superfamily Conoidea) comprise a substantial fraction of tropical marine biodiversity (>15,000 species). Prior characterization of cone snail venoms established that bioactive venom components used to capture prey, defend against ...
Zhenjian Lin +14 more
doaj +4 more sources
The mitochondrial genome of the venomous cone snail Conus consors. [PDF]
PLoS ONE, 2012 Cone snails are venomous predatory marine neogastropods that belong to the species-rich superfamily of the Conoidea. So far, the mitochondrial genomes of two cone snail species (Conus textile and Conus borgesi) have been described, and these feed on ...
Age Brauer +9 more
doaj +3 more sources
Profiling the Paralytic Effects and Lethality of Cone Snail Venom Toxins Using Nanofractionation Analytics with In Vivo Zebrafish Larvae Assays [PDF]
ToxinsThis study presents nanofractionation analytics coupled with in vivo profiling of zebrafish embryo paralysis and lethality in response to toxins in cone snail venoms.
Jeroen Kool +6 more
doaj +3 more sources
Stenotrophomonas-Like Bacteria Are Widespread Symbionts in Cone Snail Venom Ducts [PDF]
Applied and Environmental Microbiology, 2017 Cone snails are biomedically important sources of peptide drugs, but it is not known whether snail-associated bacteria affect venom chemistry. To begin to answer this question, we performed 16S rRNA gene amplicon sequencing of eight cone snail species ...
Joshua P Torres +2 more
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Venomics-Accelerated Cone Snail Venom Peptide Discovery [PDF]
International Journal of Molecular Sciences, 2018 Cone snail venoms are considered a treasure trove of bioactive peptides. Despite over 800 species of cone snails being known, each producing over 1000 venom peptides, only about 150 unique venom peptides are structurally and functionally characterized ...
S W A Himaya +2 more
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Screening and Validation of Highly-Efficient Insecticidal Conotoxins from a Transcriptome-Based Dataset of Chinese Tubular Cone Snail [PDF]
Toxins, 2017 Most previous studies have focused on analgesic and anti-cancer activities for the conotoxins identified from piscivorous and molluscivorous cone snails, but little attention has been devoted to insecticidal activity of conotoxins from the dominant ...
Bingmiao Gao, Bo Lin, Junqing Zhang
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Ero1-Mediated Reoxidation of Protein Disulfide Isomerase Accelerates the Folding of Cone Snail Toxins [PDF]
International Journal of Molecular Sciences, 2018 Disulfide-rich peptides are highly abundant in nature and their study has provided fascinating insight into protein folding, structure and function. Venomous cone snails belong to a group of organisms that express one of the largest sets of disulfide ...
Shingo Kanemura +2 more
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Venomics Reveals Venom Complexity of the Piscivorous Cone Snail, Conus tulipa [PDF]
Marine Drugs, 2019 The piscivorous cone snail Conus tulipa has evolved a net-hunting strategy, akin to the deadly Conus geographus, and is considered the second most dangerous cone snail to humans. Here, we present the first venomics study of C.
Mriga Dutt +5 more
doaj +4 more sources
Transcriptomic-Proteomic Correlation in the Predation-Evoked Venom of the Cone Snail, Conus imperialis [PDF]
Marine Drugs, 2019 Individual variation in animal venom has been linked to geographical location, feeding habit, season, size, and gender. Uniquely, cone snails possess the remarkable ability to change venom composition in response to predatory or defensive stimuli.
Ai-Hua Jin +2 more
exaly +4 more sources