Small-molecule mimicry hunting strategy in the imperial cone snail, Conus imperialis. [PDF]
Sci Adv, 2021 Venomous animals hunt using bioactive peptides, but relatively little is known about venom small molecules and the resulting complex hunting behaviors.
Torres JP +18 more
europepmc +2 more sources
Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor [PDF]
eLife, 2019 The fish-hunting marine cone snail Conus geographus uses a specialized venom insulin to induce hypoglycemic shock in its prey. We recently showed that this venom insulin, Con-Ins G1, has unique characteristics relevant to the design of new insulin ...
Peter Ahorukomeye +13 more
doaj +2 more sources
CONE SNAIL BIOLOGY, BIOPROSPECTING AND CONSERVATION [PDF]
, 2013 International audienceCone snails are predatory marine gastropods that prey on worms, molluscs and fish. The venoms of these animals are true pharmacological treasures, and with the recent approval of the first cone snail venom-derived drug, the pressure
Dutertre, Sébastien, Lewis, Richard,
core +3 more sources
Mitochondrial genome sequencing of a vermivorous cone snail Conus quercinus supports the correlative analysis between phylogenetic relationships and dietary types of Conus species. [PDF]
PLoS ONE, 2018 Complete mitochondrial genome (mitogenome) sequence of a worm-hunting cone snail, Conus quercinus, was reported in this study. Its mitogenome, the longest one (16,460 bp) among reported Conus specie, is composed of 13 protein-coding genes (PCGs), 22 ...
Bingmiao Gao +4 more
doaj +2 more sources
Cone snail venomics: From novel biology to novel therapeutics
Future Medicinal Chemistry, 2014 Peptide neurotoxins from cone snails called conotoxins are renowned for their therapeutic potential to treat pain and several neurodegenerative diseases.
Lewis, Richard J. +10 more
core +6 more sources
Neuronal Nicotinic Acetylcholine Receptor Modulators from Cone Snails [PDF]
Marine Drugs, 2018 Marine cone snails are a large family of gastropods that have evolved highly potent venoms for predation and defense. The cone snail venom has exceptional molecular diversity in neuropharmacologically active compounds, targeting a range of receptors, ion
Nikita Abraham, Richard J. Lewis
doaj +6 more sources
Structures and interactions of insulin‐like peptides from cone snail venom [PDF]
Proteins: Structure, Function and Bioinformatics, 2022 Biswajit Gorai, Harish Vashisth
exaly +2 more sources
Comparative analysis of venom genes in the chromosome-level genomes of two closely related cone snails [PDF]
BMC GenomicsBackground Venom cocktails of cone snails are characterized by their dynamic composition and the rapid evolution of toxin-encoding genes due to various selective pressures.
Ana Herráez-Pérez, Rafael Zardoya
doaj +2 more sources
Conkazal-M1 from the MKAVA family of conotoxins: A dual-function protease inhibitor and neuroactive peptide. [PDF]
Protein SciAbstract Marine cone snails produce a diverse array of bioactive peptides, known as conotoxins, in their venom. Given their high target potency and specificity, conotoxins are attractive compounds for the development of precision research tools and pharmacological agents.
Hackney CM +12 more
europepmc +2 more sources
From a Cone Snail Toxin to a Competitive MC4R Antagonist
Journal of Medicinal Chemistry, 2022 International audienceThe melanocortin 4 receptor (MC4R) plays a role in energy homeostasis and represents a target for treating energy balance disorders.
Vanden Driessche, Margot +37 more
core +5 more sources