Screening and Validation of Highly-Efficient Insecticidal Conotoxins from a Transcriptome-Based Dataset of Chinese Tubular Cone Snail [PDF]
Toxins, 2017 Most previous studies have focused on analgesic and anti-cancer activities for the conotoxins identified from piscivorous and molluscivorous cone snails, but little attention has been devoted to insecticidal activity of conotoxins from the dominant ...
Bingmiao Gao +5 more
doaj +4 more sources
Transcriptomic-Proteomic Correlation in the Predation-Evoked Venom of the Cone Snail, Conus imperialis [PDF]
Marine Drugs, 2019 Individual variation in animal venom has been linked to geographical location, feeding habit, season, size, and gender. Uniquely, cone snails possess the remarkable ability to change venom composition in response to predatory or defensive stimuli.
Ai-Hua Jin +6 more
doaj +4 more sources
Venomics-Accelerated Cone Snail Venom Peptide Discovery. [PDF]
Int J Mol Sci, 2018 Cone snail venoms are considered a treasure trove of bioactive peptides. Despite over 800 species of cone snails being known, each producing over 1000 venom peptides, only about 150 unique venom peptides are structurally and functionally characterized.
Himaya SWA, Lewis RJ.
europepmc +6 more sources
Small Molecules in the Cone Snail Arsenal. [PDF]
Org Lett, 2015 Cone snails are renowned for producing peptide-based venom, containing conopeptides and conotoxins, to capture their prey. A novel small-molecule guanine derivative with unprecedented features, genuanine, was isolated from the venom of two cone snail species.
Neves JL +6 more
europepmc +5 more sources
Predatory and Defensive Strategies in Cone Snails
ToxinsCone snails are carnivorous marine animals that prey on fish (piscivorous), worms (vermivorous), or other mollusks (molluscivorous). They produce a complex venom mostly made of disulfide-rich conotoxins and conopeptides in a compartmentalized venom gland.
Zahrmina Ratibou +2 more
doaj +3 more sources
Characterization of the First Conotoxin from Conus ateralbus, a Vermivorous Cone Snail from the Cabo Verde Archipelago [PDF]
Marine Drugs, 2019 Conus ateralbus is a cone snail endemic to the west side of the island of Sal, in the Cabo Verde Archipelago off West Africa. We describe the isolation and characterization of the first bioactive peptide from the venom of this species.
Jorge L. B. Neves +10 more
doaj +2 more sources
Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor [PDF]
eLife, 2019 The fish-hunting marine cone snail Conus geographus uses a specialized venom insulin to induce hypoglycemic shock in its prey. We recently showed that this venom insulin, Con-Ins G1, has unique characteristics relevant to the design of new insulin ...
Peter Ahorukomeye +13 more
doaj +2 more sources
Neuronal Nicotinic Acetylcholine Receptor Modulators from Cone Snails [PDF]
Marine Drugs, 2018 Marine cone snails are a large family of gastropods that have evolved highly potent venoms for predation and defense. The cone snail venom has exceptional molecular diversity in neuropharmacologically active compounds, targeting a range of receptors, ion
Nikita Abraham, Richard J. Lewis
doaj +4 more sources
Mitochondrial genome sequencing of a vermivorous cone snail Conus quercinus supports the correlative analysis between phylogenetic relationships and dietary types of Conus species. [PDF]
PLoS ONE, 2018 Complete mitochondrial genome (mitogenome) sequence of a worm-hunting cone snail, Conus quercinus, was reported in this study. Its mitogenome, the longest one (16,460 bp) among reported Conus specie, is composed of 13 protein-coding genes (PCGs), 22 ...
Bingmiao Gao +4 more
doaj +2 more sources
Venom variation during prey capture by the cone snail, Conus textile. [PDF]
PLoS ONE, 2014 Observations of the mollusc-hunting cone snail Conus textile during feeding reveal that prey are often stung multiple times in succession. While studies on the venom peptides injected by fish-hunting cone snails have become common, these approaches have ...
Cecilia A Prator +2 more
doaj +2 more sources