Combined Proteotranscriptomic-Based Strategy to Discover Novel Antimicrobial Peptides from Cone Snails [PDF]
Biomedicines, 2021 Despite their impressive diversity and already broad therapeutic applications, cone snail venoms have received less attention as a natural source in the investigation of antimicrobial peptides than other venomous animals such as scorpions, spiders, or ...
Audrey A Addablah +2 more
exaly +4 more sources
Diversity and Evolutionary Analysis of Venom Insulin Derived from Cone Snails [PDF]
ToxinsCone snails possess a diverse array of novel peptide toxins, which selectively target ion channels and receptors in the nervous and cardiovascular systems. These numerous novel peptide toxins are a valuable resource for future marine drug development. In
Linlin Ma, Jiao Chen, Bingmiao Gao
exaly +4 more sources
Cone Snails: A Big Store of Conotoxins for Novel Drug Discovery [PDF]
Toxins, 2017 Marine drugs have developed rapidly in recent decades. Cone snails, a group of more than 700 species, have always been one of the focuses for new drug discovery.
Jun-Qing Zhang, Yunhai Yi, Qiong Shi
exaly +4 more sources
The Biological Role of Conoporins, Actinoporin-like Pore-Forming Toxins from Cone Snails [PDF]
ToxinsCone snails are a large group of marine gastropods that produce a complex mixture of toxic compounds to hunt prey and defend against predators. The majority of the venom comprises small toxic peptides named conotoxins, which target membrane receptors. In
Juan C.G Galindo +2 more
exaly +4 more sources
High-Throughput Identification and Analysis of Novel Conotoxins from Three Vermivorous Cone Snails by Transcriptome Sequencing [PDF]
Marine Drugs, 2019 The venom of each Conus species consists of a diverse array of neurophysiologically active peptides, which are mostly unique to the examined species. In this study, we performed high-throughput transcriptome sequencing to extract and analyze putative ...
Ge Yao +7 more
doaj +2 more sources
Comparative Venomics of C. flavidus and C. frigidus and Closely Related Vermivorous Cone Snails [PDF]
Marine Drugs, 2022 Cone snail venom biodiversity reflects dietary preference and predatory and defensive envenomation strategies across the ≈900 species of Conidae. To better understand the mechanisms of adaptive radiations in closely related species, we investigated the ...
S. W. A. Himaya +3 more
doaj +2 more sources
Predatory and Defensive Strategies in Cone Snails [PDF]
ToxinsCone snails are carnivorous marine animals that prey on fish (piscivorous), worms (vermivorous), or other mollusks (molluscivorous). They produce a complex venom mostly made of disulfide-rich conotoxins and conopeptides in a compartmentalized venom gland.
Zahrmina Ratibou +2 more
doaj +2 more sources
Neuronal Nicotinic Acetylcholine Receptor Modulators from Cone Snails [PDF]
Marine Drugs, 2018 Marine cone snails are a large family of gastropods that have evolved highly potent venoms for predation and defense. The cone snail venom has exceptional molecular diversity in neuropharmacologically active compounds, targeting a range of receptors, ion
Nikita Abraham, Richard J. Lewis
doaj +2 more sources
Total synthesis and structural characterization of a novel protein scaffold from the snail Biomphalaria glabrata. [PDF]
Protein SciAbstract Disulfide‐rich miniproteins constitute compact and highly stable scaffolds of growing interest for molecular and structural engineering. Schistosomins are ~80‐residue proteins conserved across gastropods that form a long‐standing orphan family whose structure and biological roles have remained unknown.
Melnyk O +13 more
europepmc +2 more sources
Diversity and Novelty of Venom Peptides in Vermivorous Cone Snails, Subgenus Rhizoconus (Gastropoda: Mollusca) [PDF]
Marine DrugsA large majority of cone snails (a species in the genus Conus) are vermivorous (worm-hunting), but the diversity and bioactivity of their venom peptides remain largely unexplored.
Christine Marie C. Florece +3 more
doaj +2 more sources