Results 21 to 30 of about 2,235 (121)

Cone snail species off the Brazilian coast and their venoms: a review and update

Journal of Venomous Animals and Toxins including Tropical Diseases, 2023
The genus Conus includes over 900 species of marine invertebrates known as cone snails, whose venoms are among the most powerful described so far.
Helena B. Fiorotti, Suely G. Figueiredo, Fabiana V. Campos, Daniel C. Pimenta   +3 more
doaj   +1 more source

Structural and Functional Analyses of Cone Snail Toxins

Marine Drugs, 2019
Cone snails are marine gastropod mollusks with one of the most powerful venoms in nature. The toxins, named conotoxins, must act quickly on the cone snails´ prey due to the fact that snails are extremely slow, reducing their hunting capability ...
Harry Morales Duque, Simoni Campos Dias, Octávio Luiz Franco   +2 more
doaj   +1 more source

Coordinated adaptations define the ontogenetic shift from worm- to fish-hunting in a venomous cone snail

Nature Communications, 2023
Marine cone snails have attracted researchers from all disciplines but early life stages have received limited attention due to difficulties accessing or rearing juvenile specimens.
Aymeric Rogalski, S. W. A. Himaya, Richard J. Lewis   +2 more
doaj   +1 more source

From venom peptides to a potential diabetes treatment

eLife, 2019
Cone snails have evolved a variety of insulin-like molecules that may help with the development of better treatments for diabetes.
Jiří Jiráček, Lenka Žáková
doaj   +1 more source

A toxin-based approach to neuropeptide and peptide hormone discovery

Frontiers in Molecular Neuroscience, 2023
Peptide hormones and neuropeptides form a diverse class of bioactive secreted molecules that control essential processes in animals. Despite breakthroughs in peptide discovery, many signaling peptides remain undiscovered.
Thomas Lund Koch, Thomas Lund Koch, Joshua P. Torres, Robert P. Baskin, Robert P. Baskin, Paula Flórez Salcedo, Kevin Chase, Baldomero M. Olivera, Helena Safavi-Hemami, Helena Safavi-Hemami, Helena Safavi-Hemami   +10 more
doaj   +1 more source

Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor

eLife, 2019
The fish-hunting marine cone snail Conus geographus uses a specialized venom insulin to induce hypoglycemic shock in its prey. We recently showed that this venom insulin, Con-Ins G1, has unique characteristics relevant to the design of new insulin ...
Peter Ahorukomeye, Maria M Disotuar, Joanna Gajewiak, Santhosh Karanth, Maren Watkins, Samuel D Robinson, Paula Flórez Salcedo, Nicholas A Smith, Brian J Smith, Amnon Schlegel, Briony E Forbes, Baldomero Olivera, Danny Hung-Chieh Chou, Helena Safavi-Hemami   +13 more
doaj   +1 more source

Accelerated proteomic visualization of individual predatory venoms of Conus purpurascens reveals separately evolved predation-evoked venom cabals

Scientific Reports, 2018
Cone snail venoms have separately evolved for predation and defense. Despite remarkable inter- and intra-species variability, defined sets of synergistic venom peptides (cabals) are considered essential for prey capture by cone snails.
S. W. A. Himaya, Frank Marí, Richard J. Lewis   +2 more
doaj   +1 more source

Mitochondrial genome sequencing of a vermivorous cone snail Conus quercinus supports the correlative analysis between phylogenetic relationships and dietary types of Conus species.

PLoS ONE, 2018
Complete mitochondrial genome (mitogenome) sequence of a worm-hunting cone snail, Conus quercinus, was reported in this study. Its mitogenome, the longest one (16,460 bp) among reported Conus specie, is composed of 13 protein-coding genes (PCGs), 22 ...
Bingmiao Gao, Chao Peng, Qin Chen, Junqing Zhang, Qiong Shi   +4 more
doaj   +1 more source

Chemical Synthesis and NMR Solution Structure of Conotoxin GXIA from Conus geographus

Marine Drugs, 2021
Conotoxins are disulfide-rich peptides found in the venom of cone snails. Due to their exquisite potency and high selectivity for a wide range of voltage and ligand gated ion channels they are attractive drug leads in neuropharmacology.
David A. Armstrong, Ai-Hua Jin, Nayara Braga Emidio, Richard J. Lewis, Paul F. Alewood, K. Johan Rosengren   +5 more
doaj   +1 more source

Recruitment of Glycosyl Hydrolase Proteins in a Cone Snail Venomous Arsenal: Further Insights into Biomolecular Features of Conus Venoms

Marine Drugs, 2012
Cone snail venoms are considered an untapped reservoir of extremely diverse peptides, named conopeptides, displaying a wide array of pharmacological activities.
Philippe Favreau, Igor Križaj, Frédéric Ducancel, Reto Stöcklin, Florian Noguier, Sébastien Dutertre, Daniel Biass, David Piquemal, Yves Terrat, Adrijana Leonardi, Aude Violette   +10 more
doaj   +1 more source