Results 41 to 50 of about 2,164 (171)
Pathophysiological Responses to Conotoxin Modulation of Voltage-Gated Ion Currents
Marine Drugs, 2022 Voltage-gated ion channels are plasma membrane proteins that generate electrical signals following a change in the membrane voltage. Since they are involved in several physiological processes, their dysfunction may be responsible for a series of diseases
Elisabetta Tosti +2 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Stac2 adaptor protein is expressed in neurons and endocrine cells. Using a global Stac2 knockout mouse model here we investigated the role of endogenous Stac2 in adrenal gland mouse chromaffin cell (MCC) excitability and catecholamine vesicle exocytosis.
Stefanie M. Geisler +6 more
wiley +1 more source
Toxins, 2010 α-Conotoxins are peptide neurotoxins isolated from venomous marine cone snails that are potent and selective antagonists for different subtypes of nicotinic acetylcholine receptors (nAChRs).
Christopher J. Armishaw
doaj +1 more source
Diversity of conotoxin gene superfamilies in the venomous snail, Conus victoriae. [PDF]
PLoS ONE, 2014 Animal venoms represent a vast library of bioactive peptides and proteins with proven potential, not only as research tools but also as drug leads and therapeutics.
Samuel D Robinson +5 more
doaj +1 more source
Pharmacological Inhibition of Cav2.2 Channels by Recombinant Phα1β Toxin (CTK01512‐2)
Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 2, August 2026.The recombinant Phα1β toxin (CTK01512‐2) partially and reversibly inhibits Cav2.2 calcium channels in HEK‐293 cells. CTK01512‐2 displays dose‐dependent inhibition of N‐type calcium currents, with an IC50 of 3.94 nM. In vivo, CTK01512‐2 effectively reduces mechanical allodynia in a neuropathic pain model, confirming its antinociceptive activity ...
Natália Virtude Carobin +5 more
wiley +1 more source
The M-superfamily of conotoxins: a review [PDF]
Cellular and Molecular Life Sciences, 2009 The focus of this review is the M-superfamily of Conus venom peptides. Disulfide rich peptides belonging to the M-superfamily have three loop regions and the cysteine arrangement: CC-C-C-CC, where the dashes represent loops one, two, and three, respectively.
Jacob, Reed B., McDougal, Owen M.
openaire +3 more sources
Chronic Pain: Epidemiology, Pathophysiology, and Clinical Management
MedComm, Volume 7, Issue 5, May 2026.The multidimensional nature of chronic pain is illustrated through four interconnected domains. (Left) Epidemiology and Global Burden: Chronic pain affects approximately one in five individuals globally, contributing to a rising trend in disability‐adjusted life years (YLDs) and a significant socioeconomic impact.
Zhihao Shang +12 more
wiley +1 more source
Synthesis and Biological Activity of Novel α-Conotoxins Derived from Endemic Polynesian Cone Snails
Marine Drugs, 2023 α-Conotoxins are well-known probes for the characterization of the various subtypes of nicotinic acetylcholine receptors (nAChRs). Identifying new α-conotoxins with different pharmacological profiles can provide further insights into the physiological or
Yazid Mohamed Souf +8 more
doaj +1 more source
Marine Drugs, 2019 Conus ateralbus is a cone snail endemic to the west side of the island of Sal, in the Cabo Verde Archipelago off West Africa. We describe the isolation and characterization of the first bioactive peptide from the venom of this species.
Jorge L. B. Neves +10 more
doaj +1 more source
A Structure‐Informed Atlas of Venom‐Derived Peptides Reveals the Organization of Chemical Space
Molecular Informatics, Volume 45, Issue 5, May 2026.A structure‐informed atlas integrating sequence and AlphaFold‐derived features across 3,423 venom peptides reveals that chemical space is organized by disulfide‐stabilized compactness and electrostatic–hydrophobic balance, with functional classes clearly separated and convergent design principles overriding taxonomic origin.
Thaís Caroline Gonçalves +2 more
wiley +1 more source