Results 61 to 70 of about 4,719 (211)

The synthesis and structure of an n-terminal dodecanoic acid conjugate of a-conotoxin MII [PDF]

, 2001
The alpha-conotoxin MII is a 16 amino acid long peptide toxin isolated from the marine snail, Conus magus. This toxin has been found to be a highly selective and potent inhibitor of neuronal nicotinic acetylcholine receptors of the subtype alpha3beta2 ...
Adams, D. J., Alewood, P., Blanchfield, Joanne T., Craik, D. J., Dutton, Julie T., Hogg, R. C., Lewis, R. J., Toth, I.   +7 more
core   +1 more source

Molecular basis for a pore block of Tentonin 3 expressed in HEK293 cells by a conopeptide, NMB‐1

British Journal of Pharmacology, Volume 183, Issue 9, Page 1845-1859, May 2026.
Background and Purpose Tentonin 3 (TTN3/TMEM150C) is a mechanosensitive ion channel that plays critical roles in mechanotransduction processes. TTN3 forms a tetramer with a predicted rectangular shape and a central pore. A conotoxin ρ‐TIA and its synthetic analog, noxious mechanosensation blocker 1 (NMB‐1), were initially developed to inhibit slowly ...
Sujin Lim, Junhyuk Woo, Sungmin Pak, Joonho Paik, Gyu‐Sang Hong, Ji Hun Wi, Sanghee Lee, Cristina Fenollar‐Ferrer, Kyungreem Han, Young Kee Shin, Uhtaek Oh   +10 more
wiley   +1 more source

Characterization of the First Conotoxin from Conus ateralbus, a Vermivorous Cone Snail from the Cabo Verde Archipelago

Marine Drugs, 2019
Conus ateralbus is a cone snail endemic to the west side of the island of Sal, in the Cabo Verde Archipelago off West Africa. We describe the isolation and characterization of the first bioactive peptide from the venom of this species.
Jorge L. B. Neves, Julita S. Imperial, David Morgenstern, Beatrix Ueberheide, Joanna Gajewiak, Agostinho Antunes, Samuel D. Robinson, Samuel Espino, Maren Watkins, Vitor Vasconcelos, Baldomero M. Olivera   +10 more
doaj   +1 more source

Stabilization of a-conotoxin AuIB: influences of disulfide connectivity and backbone cyclization [PDF]

, 2011
a-Conotoxins are peptides isolated from the venom ducts of cone snails that target nicotinic acetylcholine receptors (nAChRs). They are valuable pharmacological tools and have potential applications for treating a range of conditions in humans, including
Adams, DJ, Alvarmo, C, Clark, R, Craik, D, Daly, N, Grishin, A, Gunasekera, S, Lovelace, E, Nevin, S   +8 more
core  

Structural Basis for α-Conotoxin Potency and Selectivity [PDF]

, 2009
Parkinson\u27s disease is a debilitating movement disorder characterized by altered levels of α6β2* nicotinic acetylcholine receptors (nAChRs) localized on presynaptic striatal catecholaminergic neurons.
Cornell, Kenneth A., Eidemiller, Seth, Marshall, Joshua, Martin, Bryan, McDougal, Owen M., McIntosh, J. Michael, Narver, Andrew, Turner, Matt, Zemp, Logan   +8 more
core   +2 more sources

GABAB receptor‐mediated modulation of sensory neuron excitability: Roles of CaV2.2, G‐protein‐coupled inwardly rectifying potassium (GIRK) channels, and hyperpolarisation‐activated cyclic nucleotide‐gated (HCN) channels in human and mouse nociception

Experimental Physiology, Volume 111, Issue 4, Page 2026-2043, 1 April 2026.
Abstract Chronic visceral pain is a key symptom of irritable bowel syndrome. Modulation of voltage‐gated calcium and potassium channels by G protein‐coupled receptors plays a key role in dampening nociceptive transmission. Both baclofen and the analgesic peptide α‐conotoxin Vc1.1 activate GABAB receptors (GABABR), resulting in inhibition of CaV2.2 and ...
Mariana Brizuela, Anuja R. Bony, Sonia Garcia‐Caraballo, David J. Adams, Stuart M. Brierley   +4 more
wiley   +1 more source

Design of New α-Conotoxins: From Computer Modeling to Synthesis of Potent Cholinergic Compounds

Marine Drugs, 2011
A series of 14 new analogs of α-conotoxin PnIA Conus pennaceus was synthesized and tested for binding to the human α7 nicotinic acetylcholine receptor (nAChR) and acetylcholine-binding proteins (AChBP) Lymnaea stagnalis and Aplysia californica.
Alexey Y. Khruschov, Victor I. Tsetlin, Igor E. Kasheverov, Maxim N. Zhmak   +3 more
doaj   +1 more source

Potential Therapeutic Applications of Synthetic Conotoxin s-cal14.2b, Derived from Californiconus californicus, for Treating Type 2 Diabetes

Biomedicines, 2021
The FDA’s approval of peptide drugs such as Ziconotide or Exendin for pain relief and diabetes treatment, respectively, enhanced the interest to explore novel conotoxins from Conus species venom.
Pavel H. Lugo-Fabres, Leslie M. Otero-Sastre, Johanna Bernáldez-Sarabia, Tanya A. Camacho-Villegas, Noemi Sánchez-Campos, Janeth Serrano-Bello, Luis A. Medina, Saé Muñiz-Hernández, Lizbeth de la Cruz, Isabel Arenas, Antonio Barajas-Martínez, David E. Garcia, Linda Nuñez-Garcia, Jorge González-Canudas, Alexei F. Licea-Navarro   +14 more
doaj   +1 more source

Review

, 2020
The chalcogen elements oxygen, sulfur, and selenium are essential constituents of side chain functions of natural amino acids. Conversely, no structural and biological function has been discovered so far for the heavier and more metallic tellurium ...
Agh R, Arai K, Baskakov IV, Creighton TE, Dittmer K, Du Vigneaud V, Janeček J, Metanis N, Musiol HJ, Muttenthaler M, Nygard B, O'Donnell ME, Welch M, Yang F   +13 more
core   +1 more source

NMR structure of μ-conotoxin GIIIC : leucine 18 induces local repacking of the N-terminus resulting in reduced NaV channel potency [PDF]

, 2018
mu-Conotoxins are potent and highly specific peptide blockers of voltage-gated sodium channels. In this study, the solution structure of mu-conotoxin GIIIC was determined using 2D NMR spectroscopy and simulated annealing calculations.
Adams, David J, Craik, David J, Dash, Thomas S, Durek, Thomas, Finol-Urdaneta, Rocio K, Harvey, Peta J, Hill, Justine M, Kurniawan, Nyoman D, McArthur, Jeffrey R, Van Lysebetten, Dorien   +9 more
core   +1 more source