Results 81 to 90 of about 3,374 (156)
, 2016 α-Conotoxins represent a large group of pharmacologically active peptides that antagonize nicotinic acetylcholine receptors (nAChRs). The α3β4 nAChR, a predominant subtype in the peripheral nervous system, has been implicated in various ...
Han Shen Tae (19586293) +4 more
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Plant Biotechnology Journal, Volume 24, Issue 1, Page 31-43, January 2026.Summary In plant molecular farming, recombinant products include traditional protein targets, such as antibodies, antigens, and enzymes, but also increasingly refers to high‐value peptides, and small molecules produced by heterologous enzymatic pathways.
Maxim D. Harding, Frank Sainsbury
wiley +1 more source
NMR structures of conotoxins [PDF]
, 1996 journal articleThis review discusses the methodology, structural details, and biological implications regarding NMR structures of conotoxins. NMR and molecular modeling techniques have improved to the point that three-dimensional structures of conotoxins
Mitchell, Scott S.; Shon, Ki Joon +1 more
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Physico-chemical characterization and synthesis of neuronally active alpha-conotoxins
, 2004 The high speciFIcity of alpha-conotoxins for different neuronal nicotinic acetylcholine receptors makes them important probes for dissecting receptor subtype selectivity. New sequences continue to expand the diversity and utility of the pool of available
Loughnan, M. L., Alewood, P. F.
core +1 more source
Predicting Structural Details of the Sodium Channel Pore Basing on Animal Toxin Studies
Frontiers in Pharmacology, 2018 Eukaryotic voltage-gated sodium channels play key roles in physiology and are targets for many toxins and medically important drugs. Physiology, pharmacology, and general architecture of the channels has long been the subject of intensive research in ...
Denis B. Tikhonov +2 more
doaj +1 more source
Conotoxins That Could Provide Analgesia through Voltage Gated Sodium Channel Inhibition
Toxins, 2015 Chronic pain creates a large socio-economic burden around the world. It is physically and mentally debilitating, and many suffers are unresponsive to current therapeutics.
Nehan R. Munasinghe +1 more
doaj +1 more source
Venom Diversity and Evolution in the Most Divergent Cone Snail Genus Profundiconus
Toxins, 2019 Profundiconus is the most divergent cone snail genus and its unique phylogenetic position, sister to the rest of the family Conidae, makes it a key taxon for examining venom evolution and diversity. Venom gland and foot transcriptomes of Profundiconus cf.
Giulia Fassio +8 more
doaj +1 more source
T-superfamily of conotoxins [PDF]
, 1999 journal articleWe report the discovery and initial characterization of the T-superfamily of conotoxins. Eight different T-superfamily peptides from five Conus species were identified; they share a consensus signal sequence, and a conserved ...
Walker, Craig S.; Steel, Douglas; Jacobsen, Richard B.; Lirazan, Marcelina B.; Cruz, Lourdes J.; Hooper, David; Shetty, Reshma; DelaCruz, Richard C.; Nielsen, Jacob S.; Zhou, Li Ming; Bandyopadhyay, Pradip; Craig, A. Grey +1 more
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Structure/activity relationship of alpha-conotoxins targeting GABAB receptor
, 2011 Conotoxins are small disulfide rich peptides derived from the venom of Cone snails. They target different receptors in the nervous system with high selectivity and potency making them valuable as drug leads or drug themselves.
Køller, Katrine Sperstad
core
Comparison of Teretoxin Tv1 and known M superfamily Conotoxins.
, 2014 Comparison of Teretoxin Tv1 and known M superfamily Conotoxins.
Victoria Russell (446089) +9 more
core +1 more source