Results 1 to 10 of about 15,320 (194)
Residues Responsible for the Selectivity of α-Conotoxins for Ac-AChBP or nAChRs
Marine Drugs, 2016 Nicotinic acetylcholine receptors (nAChRs) are targets for developing new drugs to treat severe pain, nicotine addiction, Alzheimer disease, epilepsy, etc. α-Conotoxins are biologically and chemically diverse. With 12–19 residues and two disulfides, they
Bo Lin, Mengsen Li
exaly +5 more sources
Assessment of [125I]a-Bungarotoxin Binding to a7 Nicotinic Acetylcholinergic Receptors in Hippocampus-Subiculum of Postmortem Human Parkinson’s Disease Brain [PDF]
BiomoleculesParkinson’s disease (PD) involves motor and cognitive impairment that nicotinic acetylcholine receptors (nAChRs) such as the α7 subtype are responsible for regulating.
Fariha Karim +4 more
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AlphaFold-Multimer modelling of linked nAChR subunits challenges concatemer design assumptions [PDF]
Scientific ReportsNicotinic acetylcholine receptors (nAChRs) are well described in vertebrates, yet less studied in arthropods, and the subunit stoichiometry and configuration of heteromeric arthropod nAChRs remains unresolved.
Hanna Magdalena Sahlström +5 more
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Sulfonium Ligands of the α7 nAChR [PDF]
Molecules, 2021 The α7 nicotinic acetylcholine receptor (nAChR) is an important target given its role in cognitive function as well as in the cholinergic anti-inflammatory pathway, where ligands that are effective at stabilizing desensitized states of the receptor are of particular interest.
Nicole A. Horenstein +2 more
openaire +3 more sources
Universal nature of cholinergic regulation demonstrated with nicotinic acetylcholine receptors
BBA Advances, 2022 Mammalian nicotinic acetylcholine receptors (nAChRs) were initially discovered as ligand-gated ion channels mediating fast synaptic transmission in the neuro-muscular junctions and autonomic ganglia. They were further found to be involved in a wide range
Maryna Skok
doaj +1 more source
Nicotinic Acetylcholine Receptors as Potential Tumor Biomarkers in Genitourinary Cancers: a Review Study [PDF]
ImmunoAnalysis, 2021 The genitourinary tissues express the different subtypes of nicotinic acetylcholine receptors (nAChRs), which are involved in many physiologic and pathologic processes.
Khalil Hajiasgharzadeh +3 more
doaj +1 more source
Alcohol and nicotinic acetylcholine receptors [PDF]
QScience Connect, 2013 Background The frequent co-abuse of alcohol and tobacco may suggest that they share some common neurological mechanisms. For example, nicotine acts on Nicotinic acetylcholine receptors (nAChRs) in the brain to release dopamine to sustain addiction. Might
Jinsong Tang, Yanhui Liao
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 Misfolding and abnormal aggregation of α-synuclein (αSyn) have been shown to increase the risk of developing Parkinson's disease (PD). Finding some way to reduce the aggregation of αSyn is particularly important for the treatment of PD. The main route in
Jifeng Zhao +7 more
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Cell Death and Disease, 2021 Osteoarthritis (OA) is the most common chronic joint disease in the elderly population. Growing evidence indicates that a balance between autophagy and apoptosis in chondrocytes plays a key role in OA’s cartilage degradation.
Yuan Liu +8 more
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Unique Pharmacological Properties of α-Conotoxin OmIA at α7 nAChRs
Frontiers in Pharmacology, 2021 OmIA, isolated from Conus omaria venom, is a potent antagonist at α7 nAChRs. We determined the co-crystal structure of OmIA with Lymnae stagnalis acetylcholine binding protein (Ls-AChBP) that identified His5, Val10 and Asn11 as key determinants for the ...
Thao N.T. Ho +2 more
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