Results 31 to 40 of about 15,320 (194)

Pathophysiology of nAChRs: Limbic circuits and related disorders

, 2023
Human epidemiological studies have identified links between nicotine intake and stress disorders, including anxiety, depression and PTSD. Here we review the clinical evidence for activation and desensitization of nicotinic acetylcholine receptors (nAChRs)
Ian M. Etherington, Yann S. Mineur, Alexa R. Soares, Zuhair I. Abdulla, Marina R. Picciotto   +4 more
core   +1 more source

Comparative functional expression of nAChR subtypes in rodent DRG neurons

Frontiers in Cellular Neuroscience, 2013
We investigated the functional expression of nicotinic acetylcholine receptors (nAChRs) in heterogeneous populations of dissociated rat and mouse lumbar dorsal root ganglion (DRG) neurons by calcium imaging.
Nathan J. Smith, Arik J. Hone, Tosifa eMemon, Simon eBossi, Thomas E. Smith, J. Michael McIntosh, J. Michael McIntosh, J. Michael McIntosh, Baldomero M. Olivera, Russell W. Teichert   +9 more
doaj   +1 more source

Nicotinic Acetylcholine Receptor α7 Subunit Is an Essential Regulator of Seizure Susceptibility

Frontiers in Neurology, 2021
A large body of data has confirmed that α7 nicotinic acetylcholine receptors (nAChRs) play a pivotal role in cognition, memory, and other neuropsychiatric diseases, but their effect on seizure susceptibility in C57BL/6 wild-type mice is not fully ...
Peng Sun, Da-Gang Liu, Xiang-Ming Ye
doaj   +1 more source

Nicotinic Acetylcholine Receptors Control Encoding and Retrieval of Associative Recognition Memory through Plasticity in the Medial Prefrontal Cortex

Cell Reports, 2018
Summary: Nicotinic acetylcholine receptors (nAChRs) expressed in the medial prefrontal cortex have critical roles in cognitive function. However, whether nAChRs are required for associative recognition memory and the mechanisms by which nAChRs may ...
Marie H. Sabec, Susan Wonnacott, E. Clea Warburton, Zafar I. Bashir   +3 more
doaj   +1 more source

Rescue of amyloid-Beta-induced inhibition of nicotinic acetylcholine receptors by a peptide homologous to the nicotine binding domain of the alpha 7 subtype.

PLoS ONE, 2013
Alzheimer's disease (AD) is characterized by brain accumulation of the neurotoxic amyloid-β peptide (Aβ) and by loss of cholinergic neurons and nicotinic acetylcholine receptors (nAChRs).
Arthur A Nery, Margaret H Magdesian, Cleber A Trujillo, Luciana B Sathler, Maria A Juliano, Luiz Juliano, Henning Ulrich, Sergio T Ferreira   +7 more
doaj   +1 more source

Human Secreted Ly-6/uPAR Related Protein-1 (SLURP-1) Is a Selective Allosteric Antagonist of α7 Nicotinic Acetylcholine Receptor. [PDF]

PLoS ONE, 2016
SLURP-1 is a secreted toxin-like Ly-6/uPAR protein found in epithelium, sensory neurons and immune cells. Point mutations in the slurp-1 gene cause the autosomal inflammation skin disease Mal de Meleda.
Ekaterina N Lyukmanova, Mikhail A Shulepko, Denis Kudryavtsev, Maxim L Bychkov, Dmitrii S Kulbatskii, Igor E Kasheverov, Maria V Astapova, Alexey V Feofanov, Morten S Thomsen, Jens D Mikkelsen, Zakhar O Shenkarev, Victor I Tsetlin, Dmitry A Dolgikh, Mikhail P Kirpichnikov   +13 more
doaj   +1 more source

Pharmacological And Functional Comparisons Of α6/α3β2β3-Nachrs And α4β2-Nachrs Heterologously Expressed In The Human Epithelial Sh-Ep1 Cell Line

, 2018
Neuronal nicotinic acetylcholine receptors containing α6 subunits (α6 * -nAChRs) show highly restricted distribution in midbrain neurons associated with pleasure, reward, and mood control, suggesting an important impact of α6 * -nAChRs in modulating ...
Paul Whiteaker, Gao, Ming, Jie Wu, Chen, De jie, Huang, Yuan bing, Sterling Sudweeks, Gao, Fen fei, Quang-xi Su, Jason Brek Eaton, Eaton, Jason Brek, Ming Gao, De-jie Chen, Wu, Jie, Whiteaker, Paul, Steffensen, Scott C., Chang, Yong, Sudweeks, Sterling, Scott C Steffensen, Gang-gang Shi, Yong-chang Chang, Ronald J Lukas, Dharshaun, Turner, Fen-fei Gao, Lukas, Ronald J., Ma, Xiao Kuang, Shi, Gang gang, Su, Quang xi, J Michael Mcintosh, Turner Dharshaun, Xiao-kuang Ma, Yuan-bing Huang, Mcintosh, J. Michael   +31 more
core   +1 more source

Biophysical characterization of lynx‐nicotinic receptor interactions using atomic force microscopy

FASEB BioAdvances, 2021
Nicotinic acetylcholine receptors (nAChRs) are broadly expressed in the central and peripheral nervous systems, playing essential roles in cholinergic neurotransmission. The lynx family proteins, a subset of the Ly6/uPAR superfamily expressed in multiple
Avani V. Pisapati, Wenpeng Cao, Kristin R. Anderson, Griffin Jones, Katie Hoffman Holick, Paul Whiteaker, Wonpil Im, X. Frank Zhang, Julie M. Miwa   +8 more
doaj   +1 more source

Primer sequences for Nicotine receptor subunits (nAChRs).

, 2016
Primer sequences for Nicotine receptor subunits (nAChRs).
Pravin C. Singhal (335757), Judith M. Eng (3373799), Seyedeh Shadafarin Marashi Shoshtari (3373796), Xiqian Lan (219539), Ashwani Malhotra (335756), Rivka Lederman (396526), Moin A. Saleem (162077)   +6 more
core   +1 more source

α7 and β2 Nicotinic Acetylcholine Receptor Subunits Form Heteromeric Receptor Complexes that Are Expressed in the Human Cortex and Display Distinct Pharmacological Properties.

PLoS ONE, 2015
The existence of α7β2 nicotinic acetylcholine receptors (nAChRs) has recently been demonstrated in both the rodent and human brain. Since α7-containing nAChRs are promising drug targets for schizophrenia and Alzheimer's disease, it is critical to ...
Morten Skøtt Thomsen, Ruud Zwart, Daniel Ursu, Majbrit Myrup Jensen, Lars Hageman Pinborg, Gary Gilmour, Jie Wu, Emanuele Sher, Jens Damsgaard Mikkelsen   +8 more
doaj   +1 more source