Results 41 to 50 of about 15,320 (194)

Mysterious α6-containing nAChRs: function, pharmacology, and pathophysiology

, 2009
Neuronal nicotinic acetylcholine receptors (nAChRs) are the superfamily of ligand-gated ion channels and widely expressed throughout the central and peripheral nervous systems.
Guo-zhang Jin, Jie Wu, Wu, Jie, Yang, Ke Chun, Jin, Guo Zhang, Ke-chun Yang   +5 more
core   +1 more source

The role of nicotinic receptors in alcohol consumption

Pharmacological Research, 2023
The use of alcohol causes significant morbidity and mortality across the globe. Alcohol use disorder (AUD) is defined by the excessive use of this drug despite a negative impact on the individual’s life. While there are currently medications available to
Helen M. Kamens, Geneva Flarend, William J. Horton   +2 more
doaj   +1 more source

Synthetic α-Conotoxin Mutants as Probes for Studying Nicotinic Acetylcholine Receptors and in the Development of Novel Drug Leads

Toxins, 2010
α-Conotoxins are peptide neurotoxins isolated from venomous marine cone snails that are potent and selective antagonists for different subtypes of nicotinic acetylcholine receptors (nAChRs).
Christopher J. Armishaw
doaj   +1 more source

Expression and function of nicotinic acetylcholine receptors in specific neuronal populations: Focus on striatal and prefrontal circuits

Pharmacological Research
Nicotinic acetylcholine receptors (nAChRs) are widely expressed in the central nervous system and play an important role in the control of neural functions including neuronal activity, transmitter release and synaptic plasticity.
Alice Abbondanza, Anna Urushadze, Amanda Rosanna Alves-Barboza, Helena Janickova   +3 more
doaj   +1 more source

Promoting the Mathematization of Physics: Hermann Minkowski's Draft Presentations of His 1908 “Grundgleichungen” Paper

Berichte zur Wissenschaftsgeschichte, EarlyView.
I present and discuss two drafts of remarks prepared by the mathematician Hermann Minkowski (1864–1909). They were composed in December 1907 while preparing his paper on the “Basic Equations of Electromagnetic Processes in Moving Bodies” for publication in the Proceedings of the Göttingen Academy of Sciences.
Tilman Sauer
wiley   +1 more source

Small Molecules as Negative Allosteric Modulators of Alpha7 nAChRs

, 2012
Alpha7 Neuronal nicotinic acetylcholine receptors (nAChRs) are involved in essential physiological functions and play a role in disorders such as Alzheimer’s disease.
Alwassil, Osama
core   +1 more source

Cell surface localization of α3β4 nicotinic acetylcholine receptors is regulated by N-cadherin homotypic binding and actomyosin contractility. [PDF]

PLoS ONE, 2013
Neuronal nicotinic acetylcholine receptors (nAChRs) are widely expressed throughout the central and peripheral nervous system and are localized at synaptic and extrasynaptic sites of the cell membrane.
Juan L Brusés
doaj   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Lack of dystrophin functionally affects α3β2/β4-nicotinic acethylcholine receptors in sympathetic neurons of dystrophic mdx mice

Neurobiology of Disease, 2011
In the sympathetic superior cervical ganglion (SCG), nicotinic acetylcholine receptors (nAChRs) mediate fast synaptic transmission. We previously demonstrated that in SCG neurons of mdx mice, an animal model for Duchenne muscular dystrophy, lack of ...
Silvia Di Angelantonio, Maria Egle De Stefano, Alessio Piccioni, Loredana Lombardi, Cecilia Gotti, Paola Paggi   +5 more
doaj   +1 more source

Paternal Exposure to the Neonicotinoid Pesticide Clothianidin Alters Sperm MicroRNA Profiles in Mice and Intergenerationally Reduces Locomotor Activity in Male Offspring

Journal of Applied Toxicology, EarlyView.
ABSTRACT Accumulating evidence suggests that paternal environmental factors have epigenetic effects on sperm and influence offspring. Neonicotinoid pesticides (NNs), which are widely used around the world, are known to affect offspring phenotypes through maternal exposure in mice, but the effect of the paternal exposure remains unknown.
Makiko Ito, Tetsushi Hirano, Sarika Nunobiki, Ayano Yoshimoto, Yukako Hara, Yuya Ishida, Sakura Yonoichi, Youhei Mantani, Toshifumi Yokoyama, Yoshiaki Tabuchi, Yoshinori Ikenaka, Nobuhiko Hoshi   +11 more
wiley   +1 more source