Results 21 to 30 of about 15,320 (194)

Cy3-RgIA-5727 Labels and Inhibits α9-Containing nAChRs of Cochlear Hair Cells [PDF]

, 2021
Efferent cholinergic neurons inhibit sensory hair cells of the vertebrate inner ear through the combined action of calcium-permeable α9α10-containing nicotinic acetylcholine receptors (nAChRs) and associated calcium-dependent potassium channels.
Philippe F. Y. Vincent, Fuchs, Paul Albert, Zhang, Yuanyuan, Glowatzki, Elisabeth, Fisher, Fernando, Fernando Fisher, Paul Albert Fuchs, Yuanyuan Zhang, Gordon, Thomas J., McIntosh, J. Michael, Gajewiak, Joanna, Thomas J. Gordon, Elisabeth Glowatzki, Joanna Gajewiak, Vincent, Philippe F. Y., J. Michael McIntosh   +15 more
core   +1 more source

Nicotinic acetylcholine receptors: Therapeutic targets for novel ligands to treat pain and inflammation

Pharmacological Research, 2023
Nicotinic acetylcholine receptors (nAChRs) have been historically defined as ligand-gated ion channels and function as such in the central and peripheral nervous systems. Recently, however, non-ionic signaling mechanisms via nAChRs have been demonstrated
Arik J. Hone, J. Michael McIntosh
doaj   +1 more source

Additional file 2 of Smoking-mediated nicotinic acetylcholine receptors (nAChRs) for predicting outcomes for head and neck squamous cell carcinomas

, 2022
Additional file 2: Supplementary Figure 2. Survival analysis, methylated sites and immuneinfiltration analysis of hub nAChRs. Survival analysis based on the expressionof (A) α5, (B)α9, and (C) β4 nAChRs in all HNSCC patients; Methylated sites of(D) α5 ...
Liang Zhou (85586), Qiang Huang (43791), Yujie Shen (573368), Chi-Yao Hsueh (11671519), Mengyou Ji (14012451)   +4 more
core   +1 more source

Alkaloid ligands enable function of homomeric human α10 nicotinic acetylcholine receptors

Frontiers in Pharmacology, 2022
In the nervous system, nicotinic acetylcholine receptors (nAChRs) rapidly transduce a chemical signal into one that is electrical via ligand-gated ion flux through the central channel of the receptor.
Arik J. Hone, Arik J. Hone, J. Michael McIntosh, J. Michael McIntosh, J. Michael McIntosh   +4 more
doaj   +1 more source

Structure-Function Elucidation of a New α-Conotoxin, MilIA, from Conus milneedwardsi

Marine Drugs, 2019
The a-Conotoxins are peptide toxins that are found in the venom of marine cone snails and they are potent antagonists of various subtypes of nicotinic acetylcholine receptors (nAChRs).
Steve Peigneur, Prabha Devi, Andrea Seldeslachts, Samuthirapandian Ravichandran, Loïc Quinton, Jan Tytgat   +5 more
doaj   +1 more source

Nicotinic acetylcholine receptors in neurological and psychiatric diseases

Pharmacological Research, 2023
Neuronal nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that are widely distributed both pre- and post-synaptically in the mammalian brain.
Alvin V. Terry, Jr., Keri Jones, Daniel Bertrand   +2 more
doaj   +1 more source

Higher availability of α4β2 nicotinic receptors (nAChRs) in dorsal ACC is linked to more efficient interference control

, 2021
Nicotinic acetylcholine receptors (nAChRs) are widely distributed in the human brain and play an important role in the neuromodulation of brain networks implicated in attentional processes.
Wissmeyer Michael, Patrik Vuilleumier, Picard Fabienne, swann pichon, Haller Sven, Ratib Osman, Seimbille Yann, Lia Antico, Garibotto Valentina   +8 more
core   +1 more source

NACHO Mediates Nicotinic Acetylcholine Receptor Function throughout the Brain

Cell Reports, 2017
Neuronal nicotinic acetylcholine receptors (nAChRs) participate in diverse aspects of brain function and mediate behavioral and addictive properties of nicotine.
Jose A. Matta, Shenyan Gu, Weston B. Davini, Brian Lord, Edward R. Siuda, Anthony W. Harrington, David S. Bredt   +6 more
doaj   +1 more source

α-Conotoxin TxIB Inhibits Development of Morphine-Induced Conditioned Place Preference in Mice via Blocking α6β2* Nicotinic Acetylcholine Receptors

Frontiers in Pharmacology, 2021
Morphine, the main component of opium, is a commonly used analgesic in clinical practice, but its abuse potential limits its clinical application. Nicotinic acetylcholine receptors (nAChRs) in the mesolimbic circuitry play an important role in the ...
Xiaodan Li, Jian Xiong, Baojian Zhang, Dongting Zhangsun, Dongting Zhangsun, Sulan Luo, Sulan Luo   +6 more
doaj   +1 more source

Structure-Function of Neuronal Nicotinic Acetylcholine Receptor Inhibitors Derived From Natural Toxins

Frontiers in Neuroscience, 2020
Neuronal nicotinic acetylcholine receptors (nAChRs) are prototypical cation-selective, ligand-gated ion channels that mediate fast neurotransmission in the central and peripheral nervous systems.
Thao N. T. Ho, Nikita Abraham, Richard J. Lewis   +2 more
doaj   +1 more source