Results 11 to 20 of about 15,320 (194)

Central nervous system interaction and crosstalk between nAChRs and other ionotropic and metabotropic neurotransmitter receptors

Pharmacological Research, 2023
Neuronal nicotinic acetylcholine receptors (nAChRs) are widely distributed in both the peripheral and the central nervous systems. nAChRs exert a crucial modulatory influence on several brain biological processes; they are involved in a variety of ...
Federica Bono, Chiara Fiorentini, Veronica Mutti, Zaira Tomasoni, Giulia Sbrini, Hanna Trebesova, Mario Marchi, Massimo Grilli, Cristina Missale   +8 more
doaj   +3 more sources

Higher availability of α4β2 nicotinic receptors (nAChRs) in dorsal ACC is linked to more efficient interference control [PDF]

NeuroImage, 2020
Nicotinic acetylcholine receptors (nAChRs) are widely distributed in the human brain and play an important role in the neuromodulation of brain networks implicated in attentional processes.
Swann Pichon, Valentina Garibotto, Michael Wissmeyer, Yann Seimbille, Lia Antico, Osman Ratib, Patrik Vuilleumier, Sven Haller, Fabienne Picard   +8 more
doaj   +2 more sources

Neuronal Menin Overexpression Rescues Learning and Memory Phenotype in CA1-Specific α7 nAChRs KD Mice

Cells, 2021
The perturbation of nicotinic cholinergic receptors is thought to underlie many neurodegenerative and neuropsychiatric disorders, such as Alzheimer’s and schizophrenia.
Shadab Batool, Basma Akhter, Jawwad Zaidi, Frank Visser, Gavin Petrie, Matthew Hill, Naweed I. Syed   +6 more
doaj   +2 more sources

Activation of functional α7-containing nAChRs in hippocampal CA1 pyramidal neurons by physiological levels of choline in the presence of PNU-120596.

PLoS ONE, 2010
BackgroundThe level of expression of functional α7-containing nicotinic acetylcholine receptors (nAChRs) in hippocampal CA1 pyramidal neurons is believed to be very low compared to hippocampal CA1 interneurons, and for many years this expression was ...
Bopanna I Kalappa, Alexander G Gusev, Victor V Uteshev   +2 more
doaj   +2 more sources

RgIA4 Potently Blocks Mouse α9α10 nAChRs and Provides Long Lasting Protection against Oxaliplatin-Induced Cold Allodynia [PDF]

Frontiers in Cellular Neuroscience, 2017
Transcripts for α9 and α10 nicotinic acetylcholine receptor (nAChR) subunits are found in diverse tissues. The function of α9α10 nAChRs is best known in mechanosensory cochlear hair cells, but elsewhere their roles are less well-understood.
Sean B. Christensen, Arik J. Hone, Isabelle Roux, Julie Kniazeff, Jean-Philippe Pin, Grégory Upert, Denis Servent, Elisabeth Glowatzki, Elisabeth Glowatzki, J. Michael McIntosh, J. Michael McIntosh, J. Michael McIntosh   +11 more
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Nicotine-Induced Effects on Nicotinic Acetylcholine Receptors (nAChRs), Ca2+ and Brain-Derived Neurotrophic Factor (BDNF) in STC-1 Cells. [PDF]

PLoS ONE, 2016
In addition to the T2R bitter taste receptors, neuronal nicotinic acetylcholine receptors (nAChRs) have recently been shown to be involved in the bitter taste transduction of nicotine, acetylcholine and ethanol.
Jie Qian, Shobha K Mummalaneni, Reem M Alkahtani, Sunila Mahavadi, Karnam S Murthy, John R Grider, Vijay Lyall   +6 more
doaj   +3 more sources

Cholinergic receptors on intestine cells of Ascaris suum and activation of nAChRs by levamisole

International Journal for Parasitology: Drugs and Drug Resistance, 2020
Cholinergic agonists, like levamisole, are a major class of anthelmintic drugs that are known to act selectively on nicotinic acetylcholine receptors (nAChRs) on the somatic muscle and nerves of nematode parasites to produce their contraction and spastic
Mark McHugh, Paul Williams, Saurabh Verma, Jo Anne Powell-Coffman, Alan P. Robertson, Richard J. Martin   +5 more
doaj   +3 more sources

Resistance to Inhibitors of Cholinesterase 3 (Ric-3) Expression Promotes Selective Protein Associations with the Human α7-Nicotinic Acetylcholine Receptor Interactome. [PDF]

PLoS ONE, 2015
The α7-nicotinic acetylcholine receptor (α7-nAChR) is a ligand-gated ion channel widely expressed in vertebrates and is associated with numerous physiological functions.
Matthew J Mulcahy, Sydney B Blattman, Francisco J Barrantes, Ronald J Lukas, Edward Hawrot   +4 more
doaj   +1 more source

Axonal α7* nicotinic acetylcholine receptors modulate glutamatergic signaling and synaptic vesicle organization in ventral hippocampal projections

Frontiers in Neural Circuits, 2022
Modulation of the release of glutamate by activation of presynaptic nicotinic acetylcholine receptors (nAChRs) is one of the most prevalent mechanism of nicotinic facilitation of glutamatergic transmission in cortico-limbic circuits.
Chongbo Zhong, Wendy Akmentin, Lorna W. Role, David A. Talmage   +3 more
doaj   +1 more source

(−)-Adaline from the Adalia Genus of Ladybirds Is a Potent Antagonist of Insect and Specific Mammalian Nicotinic Acetylcholine Receptors

Molecules, 2022
Ladybird beetles (Coleoptera: Coccinellidae) possess strong chemical defences that are secreted in response to stress and are also found on the coating of eggs, which are rich in alkaloids that are responsible for their toxicity to other species.
David P. Richards, Rohit N. Patel, Ian R. Duce, Bhupinder P. S. Khambay, Michael A. Birkett, John A. Pickett, Ian R. Mellor   +6 more
doaj   +1 more source