Challenging the catechism of therapeutics for chronic neuropathic pain: targeting CaV2.2 interactions with CRMP2 peptides [PDF]
, 2013 Chronic neuropathic pain management is a worldwide concern. Pharmaceutical companies globally have historically targeted ion channels as the therapeutic catechism with many blockbuster successes.
Feldman, Polina, Khanna, Rajesh
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Acta Physiologica, Volume 241, Issue 11, November 2025.ABSTRACT Aim To elucidate the molecular mechanism of cold sensing by visceral sensory endings, a side‐by‐side characterization of cold‐sensitive (CS) neurons in adult mouse trigeminal (TG) and vagal ganglia (VG) was performed. Methods A combination of physiological, pharmacological, molecular, and genetic tools was employed on trigeminal and vagal ...
Katharina Gers‐Barlag +4 more
wiley +1 more source
Y-aminobutyric acid type B (GABAB) receptor expression is needed for inhibition of N-type (Cav2.2) calcium channels by analgesic a-conotoxins [PDF]
, 2012 Background: A class of analgesic a-conotoxins potently inhibits N-type calcium channels. Results: The activity of a-conotoxins Vc1.1 and RgIA was reduced following knockdown of GABAB receptor expression in sensory neurons and can be reconstituted in ...
Adams, DJ +5 more
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Beyond Conus: Phylogenetic relationships of Conidae based on complete mitochondrial genomes [PDF]
, 2017 Understanding how the extraordinary taxonomic and ecological diversity of cone snails (Caenogastropoda: Conidae) evolved requires a statistically robust phylogenetic framework, which thus far is not available. While recent molecular phylogenies have been
Puillandre, Nicolas +2 more
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DiPTH‐Cystine and PTH‐Cysteine in Disulfide Bond Analysis Using Automated Edman Degradation
Journal of Peptide Science, Volume 31, Issue 10, October 2025.The mystery of PTH‐cysteine and diPTH‐cystine in the analysis of disulfide bonds is solved. Both derivatives were synthesized and applied to Edman sequencing. A time‐efficient combined workflow applying Edman and MS/MS sequencing for a comprehensive analysis of the complex disulfide connectivity in peptides and proteins was developed.
Toni Kühl +3 more
wiley +1 more source
Calcium regulation of muscle spindle mechanosensory afferent function
Experimental Physiology, Volume 110, Issue 10, Page 1457-1472, October 1, 2025.Abstract Extracellular calcium is crucial for the normal function of muscle spindle sensory afferents. They express multiple calcium buffering proteins. Extracellular calcium is essential for recycling of synaptic‐like vesicles (SLVs) in the terminals and for the stretch‐evoked inward calcium current of the receptor potential.
Anna Simon +5 more
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Discovery Methodology of Novel Conotoxins from Conus Species
Marine Drugs, 2018 Cone snail venoms provide an ideal resource for neuropharmacological tools and drug candidates discovery, which have become a research hotspot in neuroscience and new drug development. More than 1,000,000 natural peptides are produced by cone snails, but
Ying Fu +5 more
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Three-Dimensional Structure of Conotoxin tx3a: A m-1 Branch Peptide of the M-Superfamily [PDF]
, 2008 The M-superfamily, one of eight major conotoxin superfamilies found in the venom of the cone snail, contains a Cys framework with disulfide-linked loops labeled 1, 2, and 3 (- CC1C2C3CC-). M-superfamily conotoxins can be divided into the m-1, -2, -3 and -
McDougal, Owen M. +3 more
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The Journal of Physiology, Volume 603, Issue 20, Page 6445-6465, October 15, 2025.Abstract figure legend A summary of age‐related changes contributing to reduced neurotransmission in mouse neuromuscular junctions (NMJ). At 26 months, NMJs showed potentiation in short‐term plasticity compared to 4‐ or 30‐month‐old synapses, which is a proxy for reduced probability of release within individual AZs (dashed arrow). Compared to NMJs from
Yizhi Li +7 more
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Marine pharmacology in 2009-2011: marine compounds with antibacterial, antidiabetic, antifungal, anti-inflammatory, antiprotozoal, antituberculosis, and antiviral activities; affecting the immune and nervous systems, and other miscellaneous mechanisms of action. [PDF]
, 2013 The peer-reviewed marine pharmacology literature from 2009 to 2011 is presented in this review, following the format used in the 1998–2008 reviews of this series.
A. D. Rodriguez +3 more
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