Results 71 to 80 of about 3,374 (156)

New family of conotoxins that block voltage-gated sodium channels [PDF]

, 1995
journal articleConus peptides, including ω-conotoxins and α-conotoxins (targeting calcium channels and nicotinic acetylcholine receptors, respectively) have been useful ligands in neuroscience.
Hasson, Arik; Spira, Micha E.; Li, Wenqin; Marsh, Maren, Olivera, Baldomero M.; McIntosh, J. Michael; Gray, William Robert; Hillyard, David R.   +1 more
core  

Conotoxins: chemistry and biology

, 2019
The venom of the marine predatory cone snails (genus ) has evolved for prey capture and defense, providing the basis for survival and rapid diversification of the now estimated 750+ species.
Lewis, Richard J., Alewood, Paul,, Kaas, Quentin, Alewood, Paul F., Jin, Ai-Hua, Muttenthaler, Markus, Lewis, Richard,, Craik, David,, Dutertre, Sebastien, Himaya, S.W.A., Craik, David J.   +10 more
core   +1 more source

GABAB receptor‐mediated modulation of sensory neuron excitability: Roles of CaV2.2, G‐protein‐coupled inwardly rectifying potassium (GIRK) channels, and hyperpolarisation‐activated cyclic nucleotide‐gated (HCN) channels in human and mouse nociception

Experimental Physiology, Volume 111, Issue 4, Page 2026-2043, 1 April 2026.
Abstract Chronic visceral pain is a key symptom of irritable bowel syndrome. Modulation of voltage‐gated calcium and potassium channels by G protein‐coupled receptors plays a key role in dampening nociceptive transmission. Both baclofen and the analgesic peptide α‐conotoxin Vc1.1 activate GABAB receptors (GABABR), resulting in inhibition of CaV2.2 and ...
Mariana Brizuela, Anuja R. Bony, Sonia Garcia‐Caraballo, David J. Adams, Stuart M. Brierley   +4 more
wiley   +1 more source

Therapeutic conotoxins: a US patent literature survey

, 2015
Introduction: Conotoxins are a large family of bioactive peptides derived from cone snail venom. They target specific classes of ion channels and other membrane proteins and may have therapeutic value, primarily in the management of pain.Areas covered ...
Durek, Thomas, Craik, David J.
core   +1 more source

Structure-Function of Neuronal Nicotinic Acetylcholine Receptor Inhibitors Derived From Natural Toxins

Frontiers in Neuroscience, 2020
Neuronal nicotinic acetylcholine receptors (nAChRs) are prototypical cation-selective, ligand-gated ion channels that mediate fast neurotransmission in the central and peripheral nervous systems.
Thao N. T. Ho, Nikita Abraham, Richard J. Lewis   +2 more
doaj   +1 more source

α‐Synuclein oligomers slow down action potential firing and enhance dopamine release by increasing Cav2.2 currents in midbrain dopaminergic neurons

The Journal of Physiology, Volume 604, Issue 7, Page 3094-3113, 1 April 2026.
Abstract figure legend Left: the spontaneous quantal release of dopamine (DA) occurs at very low frequency in control conditions. Right: exogenous α‐synuclein potentiates Cav2.2 currents and DA release but drastically reduces the spontaneous firing rate of substantia nigra DA neurons.
Giulia Tomagra, Anthony Battaglia, Claudio Franchino, Sara Bonzano, Federico Picollo, Giuseppe Chiantia, Antonio de Iure, Paolo Calabresi, Barbara Picconi, Emilio Carbone, Silvia De Marchis, Andrea Marcantoni, Valentina Carabelli   +12 more
wiley   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, Volume 13, Issue 18, 27 March 2026.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

Inhibition of cholinergic pathways in Drosophila melanogaster by α-conotoxins

, 2015
Nicotinic acetylcholine receptors (nAChRs) play a pivotal role in synaptic transmission of neuronal signaling pathways and are fundamentally involved in neuronal disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia.
David J Adams (18044278), Frank Mari (20027346), Tanja Godenschwege (4432717), Monica Meija (20042232), Mari Heghinian (20042229)   +4 more
core  

Conotoxins as research tools and drug leads

, 2005
The complex mixture of biologically active peptides that constitute the venom of Conus species provides a rich source of ion channel neurotoxins. These peptides, commonly known as conotoxins, exhibit a high degree of selectivity and potency for different
Alewood, Paul F., Armishaw, Christopher J.   +1 more
core   +1 more source

Alternative Pathways of Acetylcholine Release in the Colon: Role of High‐Affinity Choline Transporters

Neurogastroenterology &Motility, Volume 38, Issue 3, March 2026.
Mechanisms of Acetylcholine release, including typical and atypical release under neuronal blockade. Left panel illustrates the classical (quantal) cholinergic transmission and the right panel the mechanism described in the present study. High‐Affinity Choline Transporter (HCT), Acetylcholine (ACh), Acetylcholinesterase (ACE), and Tetrodotoxin (TTX ...
A. Martinez‐Daunis, B. Yordanova, S. Traserra, P. Vergara, M. Jimenez   +4 more
wiley   +1 more source