Results 71 to 80 of about 2,164 (171)
Cancer Reports, Volume 8, Issue 11, November 2025.ABSTRACT Background The prevalence of cancer poses significant challenges to treatment, largely because of drug resistance along with other side effects. Current studies have been investigating the growth factors more than other biologic tumor features, such as neurobiologic features.
Mohammad Hossein Azadi +3 more
wiley +1 more source
Discovery Methodology of Novel Conotoxins from Conus Species
Marine Drugs, 2018 Cone snail venoms provide an ideal resource for neuropharmacological tools and drug candidates discovery, which have become a research hotspot in neuroscience and new drug development. More than 1,000,000 natural peptides are produced by cone snails, but
Ying Fu +5 more
doaj +1 more source
Ecology and Evolution, Volume 15, Issue 11, November 2025.We examined patterns of dietary and genetic variation of a broadly distributed, Indo‐West Pacific cone snail at four sites in French Polynesia and compared them to populations at Guam, American Samoa, and Rapa Nui. Our results indicate that populations at French Polynesia possess broad and overlapping diets that are most similar to those of Rapa Nui ...
Thomas F. Duda Jr +1 more
wiley +1 more source
Predicting Structural Details of the Sodium Channel Pore Basing on Animal Toxin Studies
Frontiers in Pharmacology, 2018 Eukaryotic voltage-gated sodium channels play key roles in physiology and are targets for many toxins and medically important drugs. Physiology, pharmacology, and general architecture of the channels has long been the subject of intensive research in ...
Denis B. Tikhonov +2 more
doaj +1 more source
Conotoxins That Could Provide Analgesia through Voltage Gated Sodium Channel Inhibition
Toxins, 2015 Chronic pain creates a large socio-economic burden around the world. It is physically and mentally debilitating, and many suffers are unresponsive to current therapeutics.
Nehan R. Munasinghe +1 more
doaj +1 more source
Venom Diversity and Evolution in the Most Divergent Cone Snail Genus Profundiconus
Toxins, 2019 Profundiconus is the most divergent cone snail genus and its unique phylogenetic position, sister to the rest of the family Conidae, makes it a key taxon for examining venom evolution and diversity. Venom gland and foot transcriptomes of Profundiconus cf.
Giulia Fassio +8 more
doaj +1 more source
The Conopeptide αD-FrXXA, an Inhibitor of Voltage-Gated Potassium Channels
Marine DrugsThe conopeptide αD-FrXXA was previously isolated by our team from the venom of the vermivorous snail Conus fergusoni. This toxin is composed of two chains of 47 amino acids and inhibits neuronal and muscular subtypes of nAChR.
Luis Martínez-Hernández +3 more
doaj +1 more source
A deep learning framework (CreoPep) for target-specific design and optimization of conotoxin peptides. [PDF]
Commun ChemGe C +11 more
europepmc +1 more source
Ancestral Sequence Reconstruction Provides Insights into the Structural Diversification and Neofunctionalization of T-superfamily Conotoxins in Conus. [PDF]
Mol Biol EvolEspino SS +6 more
europepmc +1 more source