Results 51 to 60 of about 3,374 (156)
Synthesis and Biological Activity of Novel α-Conotoxins Derived from Endemic Polynesian Cone Snails
Marine Drugs, 2023 α-Conotoxins are well-known probes for the characterization of the various subtypes of nicotinic acetylcholine receptors (nAChRs). Identifying new α-conotoxins with different pharmacological profiles can provide further insights into the physiological or
Yazid Mohamed Souf +8 more
doaj +1 more source
Design of New α-Conotoxins: From Computer Modeling to Synthesis of Potent Cholinergic Compounds
Marine Drugs, 2011 A series of 14 new analogs of α-conotoxin PnIA Conus pennaceus was synthesized and tested for binding to the human α7 nicotinic acetylcholine receptor (nAChR) and acetylcholine-binding proteins (AChBP) Lymnaea stagnalis and Aplysia californica.
Alexey Y. Khruschov +3 more
doaj +1 more source
Systematic dissection of genomic features determining the vast diversity of conotoxins
BMC Genomics, 2023 Background Conus, a highly diverse species of venomous predators, has attracted significant attention in neuroscience and new drug development due to their rich collection of neuroactive peptides called conotoxins.
Jian-Wei Zheng +9 more
doaj +1 more source
Glia, Volume 74, Issue 9, September 2026.Mechanism of synthesis, release, receptor activation, uptake, and degradation of GABA in dorsal root ganglia (DRG). Left: GABA is synthesized from putrescine in satellite glial cells (SGCs). After being released by Best1 channel, it activates GABAA receptors in sensory neurons, producing a chloride current.
Natalie Jiménez‐Barrios +7 more
wiley +1 more source
Conotoxins: natural product drug leads
, 2009 Venomous marine cone snails harbour a variety of small disulfide-rich peptides called conotoxins, which target a broad range of ion channels, membrane receptors, and transporters.
Halai, Reena +3 more
core +1 more source
Discovery of Novel Conotoxin Candidates Using Machine Learning
Toxins, 2018 Cone snails (genus Conus) are venomous marine snails that inject prey with a lethal cocktail of conotoxins, small, secreted, and cysteine-rich peptides.
Qing Li +4 more
doaj +1 more source
British Journal of Pharmacology, Volume 183, Issue 17, Page 5157-5189, September 2026.The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan +3 more
wiley +1 more source
, 1991 journal articleMany successful animal and plant families have developed distinctive biochemical strategies; one of the more unusual examples is found in a group of marine gastropods, the cone snails (Conus) (1).
Olivera, Baldomero M.; Hillyard, David R. +1 more
core
Codon bias for - and -conotoxins.
, 2013 (A) shows the data for the -conotoxins, and (B) shows the data for the -conotoxins. Values presented are the weighted average of values (sensu [43], Eq. 2) for codons encoding amino acids that can be represented by two (and only two) codons. Because the
Nicolas Puillandre (369446) +2 more
core +1 more source
Journal of Cosmetic Dermatology, Volume 25, Issue 9, September 2026.ABSTRACT Background Botulinum toxin type A (BTX‐A) is the cornerstone for treating dynamic wrinkles; however, it requires reinjection every 3–4 months. Adjunctive topical creams that mimic the effect of BTX‐A and enhance its action may prolong treatment intervals.
Riad Kassem +4 more
wiley +1 more source