Results 51 to 60 of about 4,719 (211)
The introduction of marine cone snail species from the coast of the Qeshm Island, contains conotoxin palliative pain in mice [PDF]
بومشناسی آبزیان, 2019 Conotoxins are small toxic peptides that are synthesized in cone snail venom ducts. Conotoxins have analgesic effects in models animal. In this study, the analgesic effects with no toxicity of Persian Gulf cone snails, Conus coronatus, and Conus frigidus
Halimeh Rajabi +4 more
doaj
Toxins, 2017 Most previous studies have focused on analgesic and anti-cancer activities for the conotoxins identified from piscivorous and molluscivorous cone snails, but little attention has been devoted to insecticidal activity of conotoxins from the dominant ...
Bingmiao Gao +5 more
doaj +1 more source
The International Journal of Biochemistry & Cell Biology, 2000 Fil: Blanton, Michael P.
Arias, Hugo Rubén, Blanton, Michael P
openaire +2 more sources
Conotoxins Targeting Neuronal Voltage-Gated Sodium Channel Subtypes: Potential Analgesics?
Toxins, 2012 Voltage-gated sodium channels (VGSC) are the primary mediators of electrical signal amplification and propagation in excitable cells. VGSC subtypes are diverse, with different biophysical and pharmacological properties, and varied tissue distribution ...
Jeffrey R. McArthur +2 more
doaj +1 more source
Pharmacological Inhibition of Voltage-gated Ca2+ Channels for Chronic Pain Relief [PDF]
, 2014 Chronic pain is a major therapeutic problem as the current treatment options are unsatisfactory with low efficacy and deleterious side effects. Voltage-gated Ca2+ channels (VGCCs), which are multi-complex proteins consisting of α1, β, γ, and α2δ subunits,
Lee, Seungkyu
core +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Stac2 adaptor protein is expressed in neurons and endocrine cells. Using a global Stac2 knockout mouse model here we investigated the role of endogenous Stac2 in adrenal gland mouse chromaffin cell (MCC) excitability and catecholamine vesicle exocytosis.
Stefanie M. Geisler +6 more
wiley +1 more source
Pathophysiological Responses to Conotoxin Modulation of Voltage-Gated Ion Currents
Marine Drugs, 2022 Voltage-gated ion channels are plasma membrane proteins that generate electrical signals following a change in the membrane voltage. Since they are involved in several physiological processes, their dysfunction may be responsible for a series of diseases
Elisabetta Tosti +2 more
doaj +1 more source
Hydrophobic residues at position 10 of α-conotoxin PnIA influence subtype selectivity between α7 and α3β2 neuronal nicotinic acetylcholine receptors [PDF]
, 2014 Neuronal nicotinic acetylcholine receptors (nAChRs) are a diverse class of ligand-gated ion channels involved in neurological conditions such as neuropathic pain and Alzheimer's disease.
Adams, David J. +6 more
core +1 more source
Toxins, 2010 α-Conotoxins are peptide neurotoxins isolated from venomous marine cone snails that are potent and selective antagonists for different subtypes of nicotinic acetylcholine receptors (nAChRs).
Christopher J. Armishaw
doaj +1 more source
Diversity of conotoxin gene superfamilies in the venomous snail, Conus victoriae. [PDF]
PLoS ONE, 2014 Animal venoms represent a vast library of bioactive peptides and proteins with proven potential, not only as research tools but also as drug leads and therapeutics.
Samuel D Robinson +5 more
doaj +1 more source