Results 31 to 40 of about 2,164 (171)
Marine Drugs, 2021 α-Conotoxins GI and MI belong to the 3/5 subfamily of α-conotoxins and potently inhibit muscular nicotinic acetylcholine receptors (nAChRs). To date, no 3/4- or 3/6-subfamily α-conotoxins have been reported to inhibit muscular nAChRs.
Xiaoli Ma +7 more
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µ-Conotoxins as Leads in the Development of New Analgesics
Molecules, 2010 Voltage-gated sodium channels (VGSCs) contain a specific binding site for a family of cone shell toxins known as µ-conotoxins. As some VGSCs are involved in pain perception and µ-conotoxins are able to block these channels, µ-conotoxins show considerable
Raymond S. Norton
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Conotoxin Prediction: New Features to Increase Prediction Accuracy
Toxins, 2023 Conotoxins are toxic, disulfide-bond-rich peptides from cone snail venom that target a wide range of receptors and ion channels with multiple pathophysiological effects. Conotoxins have extraordinary potential for medical therapeutics that include cancer,
Lyman K. Monroe +8 more
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The A-superfamily of Conotoxins [PDF]
Journal of Biological Chemistry, 2004 The generation of functional novelty in proteins encoded by a gene superfamily is seldom well documented. In this report, we define the A-conotoxin superfamily, which is widely expressed in venoms of the predatory cone snails (Conus), and show how gene products that diverge considerably in structure and function have arisen within the same superfamily.
Ameurfina D. Santos +4 more
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Discovery and characterization of the short κA-conotoxins: A novel subfamily of excitatory conotoxins [PDF]
Toxicon, 2007 We have characterized the defining members of a novel subfamily of excitatory conotoxins, the short kappaA-conotoxins (kappaA(S)-conotoxins). kappaA-conotoxins PIVE and PIVF (kappaA-PIVE and kappaA-PIVF) were purified from Conus purpurascens venom. Both peptides elicited excitatory activity upon injection into fish.
Russell W, Teichert +4 more
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The introduction of marine cone snail species from the coast of the Qeshm Island, contains conotoxin palliative pain in mice [PDF]
بومشناسی آبزیان, 2019 Conotoxins are small toxic peptides that are synthesized in cone snail venom ducts. Conotoxins have analgesic effects in models animal. In this study, the analgesic effects with no toxicity of Persian Gulf cone snails, Conus coronatus, and Conus frigidus
Halimeh Rajabi +4 more
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Toxins, 2017 Most previous studies have focused on analgesic and anti-cancer activities for the conotoxins identified from piscivorous and molluscivorous cone snails, but little attention has been devoted to insecticidal activity of conotoxins from the dominant ...
Bingmiao Gao +5 more
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Conotoxins that Confer Therapeutic Possibilities [PDF]
Marine Drugs, 2012 Cone snails produce a distinctive repertoire of venom peptides that are used both as a defense mechanism and also to facilitate the immobilization and digestion of prey. These peptides target a wide variety of voltage- and ligand-gated ion channels, which make them an invaluable resource for studying the properties of these ion channels in normal and ...
Magbubah Essack +2 more
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Conotoxins Targeting Neuronal Voltage-Gated Sodium Channel Subtypes: Potential Analgesics?
Toxins, 2012 Voltage-gated sodium channels (VGSC) are the primary mediators of electrical signal amplification and propagation in excitable cells. VGSC subtypes are diverse, with different biophysical and pharmacological properties, and varied tissue distribution ...
Jeffrey R. McArthur +2 more
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British Journal of Pharmacology, EarlyView.The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan +3 more
wiley +1 more source