Results 31 to 40 of about 3,374 (156)

Characterization of the Native Disulfide Isomers of the Novel χ-Conotoxin PnID: Implications for Further Increasing Conotoxin Diversity

Marine Drugs, 2023
χ-Conotoxins are known for their ability to selectively inhibit norepinephrine transporters, an ability that makes them potential leads for treating various neurological disorders, including neuropathic pain.
Michael J. Espiritu, Jonathan K. Taylor, Christopher K. Sugai, Parashar Thapa, Nikolaus M. Loening, Emma Gusman, Zenaida G. Baoanan, Michael H. Baumann, Jon-Paul Bingham   +8 more
doaj   +1 more source

Characterisation of Elevenin-Vc1 from the Venom of Conus victoriae: A Structural Analogue of α-Conotoxins

, 2023
Elevenins are peptides found in a range of organisms, including arthropods, annelids, nematodes, and molluscs. They consist of 17 to 19 amino acid residues with a single conserved disulfide bond.
Samuel D Robinson (20268759), Helena Safavi-Hemami (365225), Alessia Belgi (1705612), David J Adams (8273148), Bankala Krishnarjuna (1344501), Andrea J Robinson (15789440), Punnepalli Sunanda (20268756), Jeffrey Seow (9415776), Raymond S Norton (9621032), Han Shen Tae (20023188)   +9 more
core   +1 more source

Structural and Functional Diversities among μ-Conotoxins Targeting TTX-resistant Sodium Channels^†

, 2016
μ-Conotoxins are peptides that block sodium channels. Molecular cloning was used to identify four novel μ-conotoxins:  CnIIIA, CnIIIB, CIIIA, and MIIIA from Conus consors, C. catus and C. magus.
James E. Garrett (2646817), Maren Watkins (369452), Doju Yoshikami (1576675), Phillip Catlin (2646820), Brian J. Smith (203813), Grzegorz Bulaj (482751), Brad R. Green (2014306), Min-Min Zhang (1576672), Brian Fiedler (2477860), Baldomero M. Olivera (369455)   +9 more
core   +6 more sources

Transforming conotoxins into cyclotides: Backbone cyclization of P-superfamily conotoxins

, 2015
Peptide backbone cyclization is a widely used approach to improve the activity and stability of small peptides but until recently it had not been applied to peptides with multiple disulfide bonds.
David J Adams (18044278), Frank Mari (20027346), Anne Conibear (20046672), Talwar Sahil (20046675), Mari Heghinian (20042229), R Clark (9720503), Muharrem Akcan (2492818), Andrew de Faoite (20024907), N Daly (9197810), John Craik (20017755)   +9 more
core   +2 more sources

The 3/4- and 3/6-Subfamily Variants of α-Conotoxins GI and MI Exhibit Potent Inhibitory Activity against Muscular Nicotinic Acetylcholine Receptors

Marine Drugs, 2021
α-Conotoxins GI and MI belong to the 3/5 subfamily of α-conotoxins and potently inhibit muscular nicotinic acetylcholine receptors (nAChRs). To date, no 3/4- or 3/6-subfamily α-conotoxins have been reported to inhibit muscular nAChRs.
Xiaoli Ma, Qiuyuan Huang, Shuo Yu, Shujing Xu, Yue Huang, Zhiming Zhao, Xinrong Xiao, Qiuyun Dai   +7 more
doaj   +1 more source

Novel omega-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes [PDF]

, 2000
omega -Conotoxins selective for N-type calcium channels are useful in the management of severe pain. In an attempt to expand the therapeutic potential of this class, four new omega -conotoxins (CVIA-D) have been discovered in the venom of the piscivorous
Jones, A., Alewood, Paul F., Thomas, L., Sharpe, I. A., Loughnan, M. L., Craik, D. J., Alewood, P. F., Drinkwater, R., Adams, D. J., Matheson, Jodi-Lea, Lewis, R. J., Nielsen, K. J., Sharpe, Iain A., Andrews, P. R., Bond, Trudy, Matheson, J. L., Adams, Denise A., Bond, T., Adams, David J., Loughnan, Marion L., Andrews, Peter R., Luchian, T., Craik, David J., Thomas, Linda, Luchian, Tudor, Lewis, Richard J., Drinkwater, Roger, Nielsen, Katherine J., Jones, Alun, Adams, D. A.   +29 more
core   +2 more sources

Conotoxin Prediction: New Features to Increase Prediction Accuracy

Toxins, 2023
Conotoxins are toxic, disulfide-bond-rich peptides from cone snail venom that target a wide range of receptors and ion channels with multiple pathophysiological effects. Conotoxins have extraordinary potential for medical therapeutics that include cancer,
Lyman K. Monroe, Duc P. Truong, Jacob C. Miner, Samantha H. Adikari, Zachary J. Sasiene, Paul W. Fenimore, Boian Alexandrov, Robert F. Williams, Hau B. Nguyen   +8 more
doaj   +1 more source

Screening and Validation of Highly-Efficient Insecticidal Conotoxins from a Transcriptome-Based Dataset of Chinese Tubular Cone Snail

Toxins, 2017
Most previous studies have focused on analgesic and anti-cancer activities for the conotoxins identified from piscivorous and molluscivorous cone snails, but little attention has been devoted to insecticidal activity of conotoxins from the dominant ...
Bingmiao Gao, Chao Peng, Bo Lin, Qin Chen, Junqing Zhang, Qiong Shi   +5 more
doaj   +1 more source

Venomous secretions from marine snails of the Terebridae family target acetylcholine receptors [PDF]

, 2013
Venoms from cone snails (Conidae) have been extensively studied during the last decades, but those from other members of the suborder Toxoglossa, such as of Terebridae and Turridae superfamilies attracted less interest so far. Here, we report the effects
Wunder, C., Peigneur, S., Silke Kauferstein, Melaun, Christian, Annette Nicke, Nicke, Annette, Dietrich Mebs, Christian Melaun, Peigneur, Steve, Kauferstein, S., Kauferstein, Silke, Wunder, Cora, Kendel, Y., Mebs, D., Kurz, A., Steve Peigneur, Tytgat, Jan, Melaun, C., Kendel, Yvonne, Kurz, Alexander, Mebs, Dietrich, Yvonne Kendel, Jan Tytgat, Cora Wunder, Alexander Kurz, Nicke, A., Tytgat, J.   +26 more
core   +1 more source

The introduction of marine cone snail species from the coast of the Qeshm Island, contains conotoxin palliative pain in mice [PDF]

بوم‌شناسی آبزیان, 2019
Conotoxins are small toxic peptides that are synthesized in cone snail venom ducts. Conotoxins have analgesic effects in models animal. In this study, the analgesic effects with no toxicity of Persian Gulf cone snails, Conus coronatus, and Conus frigidus
Halimeh Rajabi, Hossein Zolgharnen, Mohammad Taghi Ronagh, Ahmad Savari, Mohammad Sharif Ranjbar   +4 more
doaj