Results 21 to 30 of about 3,374 (156)
Interaction of α9α10 Nicotinic Receptors With Peptides and Proteins From Animal Venoms
Frontiers in Cellular Neuroscience, 2021 Unlike most neuronal nicotinic acetylcholine receptor (nAChR) subunits, α7, α9, and α10 subunits are able to form functional homo- or heteromeric receptors without any β subunits.
Victor Tsetlin +11 more
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Biomedicines, 2020 Conotoxins form a diverse group of peptide toxins found in the venom of predatory marine cone snails. Decades of conotoxin research have provided numerous measurable scientific and societal benefits.
Walden E. Bjørn-Yoshimoto +6 more
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Conotoxins: structure, therapeutic potential and pharmacological applications. [PDF]
, 2016 Cone snails, also known as marine gastropods, from Conus genus produce in their venom a diverse range of small pharmacologically active structured peptides called conotoxins.
Mir, R. +4 more
core +1 more source
Diversity of Conopeptides and Their Precursor Genes of Conus Litteratus
Marine Drugs, 2020 The venom of various Conus species is composed of a rich variety of unique bioactive peptides, commonly referred to as conotoxins (conopeptides). Most conopeptides have specific receptors or ion channels as physiologically relevant targets. In this paper,
Xinjia Li +3 more
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Conus regius-Derived Conotoxins: Novel Therapeutic Opportunities from a Marine Organism
Marine Drugs, 2022 Conus regius is a marine venomous mollusk of the Conus genus that captures its prey by injecting a rich cocktail of bioactive disulfide bond rich peptides called conotoxins.
Francesco Margiotta +5 more
doaj +1 more source
Effects of Selenocysteine Substitution on the Cyclotide Kalata B2. [PDF]
ChembiochemSelenocysteine (Sec) substitution of any of the native complementary cysteine (Cys) residues of the cyclotide kalata B2 preserves the structure, cytotoxicity, and membrane‐binding activity while enhancing its folding efficiency. The study shows the conservative nature and folding benefit of selenocysteine replacement in kalata B2.
de Boda RLB +5 more
europepmc +2 more sources
Toxinology of Marine Venomous Snails
Iranian South Medical Journal, 2021 A surprisingly large number of sea snail species are venomous. Cone snail venoms are produced in a lengthy tubular duct from a complex venom gland and form a cocktail of many toxins, particularly conotoxins which have high potency and specificity for ...
Gholam Hossein Mohebbi, Iraj Nabipour
doaj
Recent Advances in Conotoxin Classification by Using Machine Learning Methods
Molecules, 2017 Conotoxins are disulfide-rich small peptides, which are invaluable peptides that target ion channel and neuronal receptors. Conotoxins have been demonstrated as potent pharmaceuticals in the treatment of a series of diseases, such as Alzheimer’s disease,
Fu-Ying Dao +8 more
doaj +1 more source
Marine Drugs, 2019 The venom of each Conus species consists of a diverse array of neurophysiologically active peptides, which are mostly unique to the examined species. In this study, we performed high-throughput transcriptome sequencing to extract and analyze putative ...
Ge Yao +7 more
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Structural and Functional Analyses of Cone Snail Toxins
Marine Drugs, 2019 Cone snails are marine gastropod mollusks with one of the most powerful venoms in nature. The toxins, named conotoxins, must act quickly on the cone snails´ prey due to the fact that snails are extremely slow, reducing their hunting capability ...
Harry Morales Duque +2 more
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