Results 21 to 30 of about 4,719 (211)
Alpha9 nicotinic acetylcholine receptors and the treatment of pain [PDF]
, 2009 Chronic pain is a vexing worldwide problem that causes substantial disability and consumes significant medical resources. Although there are numerous analgesic medications, these work through a small set of molecular mechanisms.
Absalom, Nathan +4 more
core +1 more source
Diversity of Conopeptides and Their Precursor Genes of Conus Litteratus
Marine Drugs, 2020 The venom of various Conus species is composed of a rich variety of unique bioactive peptides, commonly referred to as conotoxins (conopeptides). Most conopeptides have specific receptors or ion channels as physiologically relevant targets. In this paper,
Xinjia Li +3 more
doaj +1 more source
Conus regius-Derived Conotoxins: Novel Therapeutic Opportunities from a Marine Organism
Marine Drugs, 2022 Conus regius is a marine venomous mollusk of the Conus genus that captures its prey by injecting a rich cocktail of bioactive disulfide bond rich peptides called conotoxins.
Francesco Margiotta +5 more
doaj +1 more source
A novel α-conotoxin, PeIA, cloned from Conus pergrandis, discriminates between Rat α9α10 and α7 nicotinic cholinergic receptors [PDF]
, 2005 The α9 and α10 nicotinic cholinergic subunits assemble to form the receptor believed to mediate synaptic transmission between efferent olivocochlear fibers and hair cells of the cochlea, one of the few examples of postsynaptic function for a non-muscle ...
Arredondo +59 more
core +1 more source
Venomous secretions from marine snails of the Terebridae family target acetylcholine receptors [PDF]
, 2013 Venoms from cone snails (Conidae) have been extensively studied during the last decades, but those from other members of the suborder Toxoglossa, such as of Terebridae and Turridae superfamilies attracted less interest so far. Here, we report the effects
Kauferstein, Silke +8 more
core +3 more sources
Structural studies of conotoxins [PDF]
IUBMB Life, 2009 AbstractConotoxins are small disulfide‐rich peptides from the venoms of marine cone snails. They target a variety of ion channels, transporters, and receptors besides the interest in their natural functions in venoms and they are of much interest as drug leads.
Daly, Norelle L., Craik, David J.
openaire +3 more sources
Marine Drugs, 2017 Conotoxins in the venom of cone snails (Conus spp.) are a mixture of active peptides that work as blockers, agonists, antagonists, or inactivators of various ion channels.
Yu Huang +4 more
doaj +1 more source
Conopeptides from Cape Verde Conus crotchii [PDF]
, 2013 Marine Cone snails of the genus Conus contain complex peptide toxins in their venom. Living in tropical habitats, they usually use the powerful venom for self-defense and prey capture.
Agostinho Antunes +14 more
core +1 more source
Toxinology of Marine Venomous Snails
Iranian South Medical Journal, 2021 A surprisingly large number of sea snail species are venomous. Cone snail venoms are produced in a lengthy tubular duct from a complex venom gland and form a cocktail of many toxins, particularly conotoxins which have high potency and specificity for ...
Gholam Hossein Mohebbi, Iraj Nabipour
doaj
Recent Advances in Conotoxin Classification by Using Machine Learning Methods
Molecules, 2017 Conotoxins are disulfide-rich small peptides, which are invaluable peptides that target ion channel and neuronal receptors. Conotoxins have been demonstrated as potent pharmaceuticals in the treatment of a series of diseases, such as Alzheimer’s disease,
Fu-Ying Dao +8 more
doaj +1 more source