Results 21 to 30 of about 2,164 (171)
Conus regius-Derived Conotoxins: Novel Therapeutic Opportunities from a Marine Organism
Marine Drugs, 2022 Conus regius is a marine venomous mollusk of the Conus genus that captures its prey by injecting a rich cocktail of bioactive disulfide bond rich peptides called conotoxins.
Francesco Margiotta +5 more
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Marine Drugs, 2017 Conotoxins in the venom of cone snails (Conus spp.) are a mixture of active peptides that work as blockers, agonists, antagonists, or inactivators of various ion channels.
Yu Huang +4 more
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Conotoxins and their regulatory considerations [PDF]
Regulatory Toxicology and Pharmacology, 2014 Venom derived peptides from marine cone snails, conotoxins, have demonstrated unique pharmacological targeting properties that have been pivotal in advancing medical research. The awareness of their true toxic origins and potent pharmacological nature is emphasized by their 'select agent' classification by the US Centers for Disease Control and ...
Parashar Thapa +3 more
openaire +3 more sources
Toxinology of Marine Venomous Snails
Iranian South Medical Journal, 2021 A surprisingly large number of sea snail species are venomous. Cone snail venoms are produced in a lengthy tubular duct from a complex venom gland and form a cocktail of many toxins, particularly conotoxins which have high potency and specificity for ...
Gholam Hossein Mohebbi, Iraj Nabipour
doaj
Recent Advances in Conotoxin Classification by Using Machine Learning Methods
Molecules, 2017 Conotoxins are disulfide-rich small peptides, which are invaluable peptides that target ion channel and neuronal receptors. Conotoxins have been demonstrated as potent pharmaceuticals in the treatment of a series of diseases, such as Alzheimer’s disease,
Fu-Ying Dao +8 more
doaj +1 more source
Marine Drugs, 2019 The venom of each Conus species consists of a diverse array of neurophysiologically active peptides, which are mostly unique to the examined species. In this study, we performed high-throughput transcriptome sequencing to extract and analyze putative ...
Ge Yao +7 more
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Structural and Functional Analyses of Cone Snail Toxins
Marine Drugs, 2019 Cone snails are marine gastropod mollusks with one of the most powerful venoms in nature. The toxins, named conotoxins, must act quickly on the cone snails´ prey due to the fact that snails are extremely slow, reducing their hunting capability ...
Harry Morales Duque +2 more
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Marine Drugs, 2023 χ-Conotoxins are known for their ability to selectively inhibit norepinephrine transporters, an ability that makes them potential leads for treating various neurological disorders, including neuropathic pain.
Michael J. Espiritu +8 more
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µ-Conotoxins Targeting the Human Voltage-Gated Sodium Channel Subtype NaV1.7
Toxins, 2022 µ-Conotoxins are small, potent, peptide voltage-gated sodium (NaV) channel inhibitors characterised by a conserved cysteine framework. Despite promising in vivo studies indicating analgesic potential of these compounds, selectivity towards the ...
Kirsten L. McMahon +5 more
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Conotoxins: Therapeutic Potential and Application
Marine Drugs, 2006 The pharmacological variety of conotoxins, diverse peptides found in the venoms of marine cone snails, is well recognized. Venoms from each of the estimated 500 species of cone snails contain 50 to 200 distinct biologically active peptides.
Richard T. Layer, J. Michael McIntosh
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