Results 31 to 40 of about 771 (173)

Discovery of KV1.3 ion channel inhibitors: Medicinal chemistry approaches and challenges

Medicinal Research Reviews, Volume 41, Issue 4, Page 2423-2473, July 2021., 2021
Abstract The KV1.3 voltage‐gated potassium ion channel is involved in many physiological processes both at the plasma membrane and in the mitochondria, chiefly in the immune and nervous systems. Therapeutic targeting KV1.3 with specific peptides and small molecule inhibitors shows great potential for treating cancers and autoimmune diseases, such as ...
Špela Gubič, Louise A. Hendrickx, Žan Toplak, Maša Sterle, Steve Peigneur, Tihomir Tomašič, Luis A. Pardo, Jan Tytgat, Anamarija Zega, Lucija P. Mašič   +9 more
wiley   +1 more source

Identification of Novel Conopeptides and Distinct Gene Superfamilies in the Marine Cone Snail Conus quercinus

Frontiers in Marine Science, 2021
Conopeptides from the marine cone snails are a mixture of cysteine-rich active peptides, representing a unique and fertile resource for neuroscience research and drug discovery.
Han Zhang, Han Zhang, Han Zhang, Lei Wang, Xiang Yang, Xiang Yang, Xiang Yang, Zhiwei Lian, Zhiwei Lian, Yinbin Qiu, Yinbin Qiu, Zhanying Dong, Zhanying Dong, Xuedong Wu, Xuedong Wu, Xinghua Pan, Xinghua Pan, Xinghua Pan, Xinghua Pan   +18 more
doaj   +1 more source

ConoDictor: a tool for prediction of conopeptide superfamilies [PDF]

Nucleic Acids Research, 2012
ConoDictor is a tool that enables fast and accurate classification of conopeptides into superfamilies based on their amino acid sequence. ConoDictor combines predictions from two complementary approaches-profile hidden Markov models and generalized profiles. Results appear in a browser as tables that can be downloaded in various formats.
Dominique Koua, Age Brauer, Silja Laht, Lauris Kaplinski, Philippe Favreau, Maido Remm, Frédérique Lisacek, Reto Stöcklin   +7 more
openaire   +3 more sources

A novel μ-conopeptide, CnIIIC, exerts potent and preferential inhibition of NaV1.2/1.4 channels and blocks neuronal nicotinic acetylcholine receptors [PDF]

, 2012
BACKGROUND AND PURPOSE The μ-conopeptide family is defined by its ability to block voltage-gated sodium channels (VGSCs), a property that can be used for the development of myorelaxants and analgesics.
Stocklin, Reto, D' hoedt, Dieter, Carlier, Ludovic, Boelens, Rolf, Bertrand, Daniel, Heinemann, Stefan H., Heinemann, Stefan H, Benoit, Evelyne, Tytgat, Jan, Markgraf, René, Molgo, Jordi, Córdova, Marco A., Schlumberger, Sébastien, Hocking, Henry G., Hartley, Oliver, Favreau, Philippe, Stoecklin, Reto, Gaertner, Hubert, Paolini-Bertrand, Marianne, Leipold, Enrico, Gaertner, Hubert François, Córdova, Marco A, Bert, D'Hoedt, Dieter, Hocking, Henry G   +24 more
core   +3 more sources

ConoServer, a database for conopeptide sequences and structures [PDF]

Bioinformatics, 2007
Abstract Summary: ConoServer is a new database dedicated to conopeptides, a large family of peptides found in the venom of marine snails of the genus Conus. These peptides have an exceptional diversity of sequences and chemical modifications and their ability to block ion channels makes them important as drug leads and tools for ...
Quentin Kaas, Jan-C. Westermann, Reena Halai, Conan K. L. Wang, David J. Craik   +4 more
openaire   +5 more sources

Molecular Phylogeny, Classification and Evolution of Conopeptides [PDF]

Journal of Molecular Evolution, 2012
Conopeptides are toxins expressed in the venom duct of cone snails (Conoidea, Conus). These are mostly well-structured peptides and mini-proteins with high potency and selectivity for a broad range of cellular targets. In view of these properties, they are widely used as pharmacological tools and many are candidates for innovative drugs.
Puillandre, N., Koua, D., Favreau, P., Olivera, B., Stöcklin, R.   +4 more
openaire   +3 more sources

Mechanisms for Evolving Hypervariability: The Case of Conopeptides [PDF]

Molecular Biology and Evolution, 2001
Hypervariability is a prominent feature of large gene families that mediate interactions between organisms, such as venom-derived toxins or immunoglobulins. In order to study mechanisms for evolution of hypervariability, we examined an EST-generated assemblage of 170 distinct conopeptide sequences from the venoms of five species of marine Conus snails.
S G, Conticello, Y, Gilad, N, Avidan, E, Ben-Asher, Z, Levy, M, Fainzilber   +5 more
openaire   +2 more sources

Curses or Cures: A Review of the Numerous Benefits Versus the Biosecurity Concerns of Conotoxin Research

Biomedicines, 2020
Conotoxins form a diverse group of peptide toxins found in the venom of predatory marine cone snails. Decades of conotoxin research have provided numerous measurable scientific and societal benefits.
Walden E. Bjørn-Yoshimoto, Iris Bea L. Ramiro, Mark Yandell, J. Michael McIntosh, Baldomero M. Olivera, Lars Ellgaard, Helena Safavi-Hemami   +6 more
doaj   +1 more source

Conotoxin Gene Superfamilies

Marine Drugs, 2014
Conotoxins are the peptidic components of the venoms of marine cone snails (genus Conus). They are remarkably diverse in terms of structure and function. Unique potency and selectivity profiles for a range of neuronal targets have made several conotoxins
Samuel D. Robinson, Raymond S. Norton
doaj   +1 more source

A novel proline-rich M-superfamily conotoxin that can simultaneously affect sodium, potassium and calcium currents

Journal of Venomous Animals and Toxins including Tropical Diseases, 2021
Background Conotoxins have become a research hotspot in the neuropharmacology field for their high activity and specificity in targeting ion channels and neurotransmitter receptors.
Manyi Yang, Yubin Li, Longfei Liu, Maojun Zhou   +3 more
doaj   +1 more source