Results 51 to 60 of about 771 (173)

Diversity of Conopeptides and Their Precursor Genes of Conus Litteratus. [PDF]

Mar Drugs, 2020
The venom of various Conus species is composed of a rich variety of unique bioactive peptides, commonly referred to as conotoxins (conopeptides). Most conopeptides have specific receptors or ion channels as physiologically relevant targets. In this paper, high-throughput transcriptome sequencing was performed to analyze putative conotoxin transcripts ...
Li X, Chen W, Zhangsun D, Luo S.
europepmc   +5 more sources

Structure-Function Elucidation of a New α-Conotoxin, MilIA, from Conus milneedwardsi

Marine Drugs, 2019
The a-Conotoxins are peptide toxins that are found in the venom of marine cone snails and they are potent antagonists of various subtypes of nicotinic acetylcholine receptors (nAChRs).
Steve Peigneur, Prabha Devi, Andrea Seldeslachts, Samuthirapandian Ravichandran, Loïc Quinton, Jan Tytgat   +5 more
doaj   +1 more source

Toxins 'R' Us : more pharmacological tools from nature's superstore

, 2002
Conus venoms from marine cone snails continue to provide novel bioactive components. Two new classes of conopeptide specifically block alpha(1)-adrenoceptors (rho-conopeptide) and noradrenaline transporters (chi-conopeptides).
Alan L Harvey, Harvey, Alan L
core   +4 more sources

Snails In Silico: A Review of Computational Studies on the Conopeptides [PDF]

Marine Drugs, 2019
Marine cone snails are carnivorous gastropods that use peptide toxins called conopeptides both as a defense mechanism and as a means to immobilize and kill their prey. These peptide toxins exhibit a large chemical diversity that enables exquisite specificity and potency for target receptor proteins.
Rachael A. Mansbach, Timothy Travers, Benjamin H. McMahon, Jeanne M. Fair, S. Gnanakaran   +4 more
openaire   +3 more sources

Cy3-RgIA-5727 Labels and Inhibits α9-Containing nAChRs of Cochlear Hair Cells

Frontiers in Cellular Neuroscience, 2021
Efferent cholinergic neurons inhibit sensory hair cells of the vertebrate inner ear through the combined action of calcium-permeable α9α10-containing nicotinic acetylcholine receptors (nAChRs) and associated calcium-dependent potassium channels.
Fernando Fisher, Yuanyuan Zhang, Philippe F. Y. Vincent, Joanna Gajewiak, Thomas J. Gordon, Elisabeth Glowatzki, Paul Albert Fuchs, J. Michael McIntosh, J. Michael McIntosh, J. Michael McIntosh   +9 more
doaj   +1 more source

A novel inhibitor of α9α10 nicotinic acetylcholine receptors from Conus vexillum delineates a new conotoxin superfamily. [PDF]

PLoS ONE, 2013
Conotoxins (CTxs) selectively target a range of ion channels and receptors, making them widely used tools for probing nervous system function. Conotoxins have been previously grouped into superfamilies according to signal sequence and into families based
Sulan Luo, Sean Christensen, Dongting Zhangsun, Yong Wu, Yuanyan Hu, Xiaopeng Zhu, Sandeep Chhabra, Raymond S Norton, J Michael McIntosh   +8 more
doaj   +1 more source

Analysis of venom gland transcriptomes from two Tesseliconus species, Conus eburneus and Conus tessulatus, reveals inter- and intra-specific variations in conopeptide diversity and expression as well as putative novel gene superfamilies and disulfide-poor venom components

Frontiers in Marine Science
The Conus subgenus Tesseliconus, whose members are believed to be primarily worm-hunters, phylogenetically clusters closely with piscivorous groups relative to most other vermivorous subgenera. A previous study even documented the Tesseliconus species C.
Francis A. Tablizo, Francis A. Tablizo, Dan Jethro M. Masacupan, Dan Jethro M. Masacupan, Arturo O. Lluisma   +4 more
doaj   +1 more source

Antimycobacterial Activity: A New Pharmacological Target for Conotoxins Found in the First Reported Conotoxin from Conasprella ximenes

Toxins, 2018
Mycobacterium tuberculosis is the etiological agent of tuberculosis, an airborne infectious disease that is a leading cause of human morbidity and mortality worldwide.
Andrea Figueroa-Montiel, Johanna Bernáldez, Samanta Jiménez, Beatrix Ueberhide, Luis Javier González, Alexei Licea-Navarro   +5 more
doaj   +1 more source

α‐RgIB: A Novel Antagonist Peptide of Neuronal Acetylcholine Receptor Isolated from Conus regius Venom

International Journal of Peptides, Volume 2013, Issue 1, 2013., 2013
Conus venoms are rich sources of biologically active peptides that act specifically on ionic channels and metabotropic receptors present at the neuromuscular junction, efficiently paralyzing the prey. Each species of Conus may have 50 to 200 uncharacterized bioactive peptides with pharmacological interest.
Maria Cristina Vianna Braga, Arthur Andrade Nery, Henning Ulrich, Katsuhiro Konno, Juliana Mozer Sciani, Daniel Carvalho Pimenta, Ayman El-Faham   +6 more
wiley   +1 more source

Cupryphans, metal‐binding, redox‐active, redesigned conopeptides [PDF]

Protein Science, 2009
AbstractContryphans are bioactive peptides, isolated from the venom of marine snails of the genus Conus, which are characterized by the short length of the polypeptide chain and the high degree of unusual post‐translational modifications. The cyclization of the polypeptide chain through a single disulphide bond, the presence of two conserved Pro ...
BARBA, MARCO, A. P. SOBOLEV, C. ROMEO, SCHININA', Maria Eugenia, D. PIETRAFORTE, MANNINA, LUISA, G. MUSCI, F. POLTICELLI   +7 more
openaire   +6 more sources