Results 51 to 60 of about 1,087 (186)
Marine Drugs, 2019 Individual variation in animal venom has been linked to geographical location, feeding habit, season, size, and gender. Uniquely, cone snails possess the remarkable ability to change venom composition in response to predatory or defensive stimuli.
Ai-Hua Jin +6 more
doaj +1 more source
ArachnoServer 2.0, an updated online resource for spider toxin sequences and structures [PDF]
, 2011 ArachnoServer (www.arachnoserver.org) is a manually curated database providing information on the sequence, structure and biological activity of protein toxins from spider venoms.
Binford, G +8 more
core +1 more source
Conotoxins: Therapeutic Potential and Application
Marine Drugs, 2006 The pharmacological variety of conotoxins, diverse peptides found in the venoms of marine cone snails, is well recognized. Venoms from each of the estimated 500 species of cone snails contain 50 to 200 distinct biologically active peptides.
Richard T. Layer, J. Michael McIntosh
doaj +1 more source
Analgesic alpha-Conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABA-B receptor activation [PDF]
, 2008 alpha-Conotoxins Vc1.1 and Rg1A are peptides from the venom of marine Conus snails that are currently in development as a treatment for neuropathic pain. Here we report that the alpha 9 alpha 10 nicotinic acetylcholine receptor-selective conotoxins Vc1.1
Adams, David J. +5 more
core +2 more sources
Sodium Channels and Mammalian Sensory Mechanotransduction [PDF]
, 2012 Background: Members of the degenerin/epithelial (DEG/ENaC) sodium channel family are mechanosensors in C elegans, and Nav1.7 and Nav1.8 voltage-gated sodium channel knockout mice have major deficits in mechanosensation.
Edith Hummler +7 more
core +4 more sources
Structure-Function Elucidation of a New α-Conotoxin, MilIA, from Conus milneedwardsi
Marine Drugs, 2019 The a-Conotoxins are peptide toxins that are found in the venom of marine cone snails and they are potent antagonists of various subtypes of nicotinic acetylcholine receptors (nAChRs).
Steve Peigneur +5 more
doaj +1 more source
Adjuvant analgesics in neuropathic pain [PDF]
, 2009 Conventional analgesics have limited efficacy in the management of neuropathic pain. An adjuvant analgesic is a drug that has a primary nonpain indication but which may be analgesic in certain circumstances, and many of these have established a role in ...
Irwin, MG, Kong, VKF
core +1 more source
Bioactive Marine Drugs and Marine Biomaterials for Brain Diseases [PDF]
, 2014 Marine invertebrates produce a plethora of bioactive compounds, which serve as inspiration for marine biotechnology, particularly in drug discovery programs and biomaterials development.
Andrade, Paula B. +3 more
core +2 more sources
Cy3-RgIA-5727 Labels and Inhibits α9-Containing nAChRs of Cochlear Hair Cells
Frontiers in Cellular Neuroscience, 2021 Efferent cholinergic neurons inhibit sensory hair cells of the vertebrate inner ear through the combined action of calcium-permeable α9α10-containing nicotinic acetylcholine receptors (nAChRs) and associated calcium-dependent potassium channels.
Fernando Fisher +9 more
doaj +1 more source
An Annotated Draft Genome for Radix auricularia (Gastropoda, Mollusca) [PDF]
, 2017 Molluscs are the second most species-rich phylum in the animal kingdom, yet only 11 genomes of this group have been published so far. Here, we present the draft genome sequence of the pulmonate freshwater snail Radix auricularia. Six whole genome shotgun
Barbara Feldmeyer +11 more
core +2 more sources