Results 71 to 80 of about 771 (173)

New Conotoxin SO-3 Targeting N-type Voltage-Sensitive Calcium Channels

Marine Drugs, 2006
Selective blockers of the N-type voltage-sensitive calcium (CaV) channels are useful in the management of severe chronic pain. Here, the structure and function characteristics of a novel N-type CaV channel blocker, SO-3, are reviewed.
Lei Wen, Sheng Yang, Wenxia Zhou, Peitang Huang, Yongxiang Zhang   +4 more
doaj   +1 more source

Expression of α3β2β4 nicotinic acetylcholine receptors by rat adrenal chromaffin cells determined using novel conopeptide antagonists [PDF]

, 2020
Adrenal chromaffin cells release neurotransmitters in response to stress and may be involved in conditions such as post-traumatic stress and anxiety disorders.
Lola Rueda‐Ruzafa, Christensen, Sean, Hone, Arik J., Rueda Ruzafa, Lola, Almudena Albillos, Arik J. Hone, Tino Dyhring, Gordon, Thomas J., Albillos Martínez, María Almudena, McIntosh, J. Michael, Gajewiak, Joanna, Thomas J. Gordon, Sean Christensen, Dyhring, Tino, Joanna Gajewiak, J. Michael McIntosh   +15 more
core   +1 more source

Analogs of α‐conotoxin PnIC selectively inhibit α7β2‐ over α7‐only subtype nicotinic acetylcholine receptors via a novel allosteric mechanism

The FASEB Journal, Volume 38, Issue 1, 15 January 2024.
Analogs of α‐conotoxin PnIC selectively inhibit α7β2‐ over α7‐only subtype nicotinic acetylcholine receptors via a novel allosteric mechanism.Andrew A. George, Sabin J. John, Linda M. Lucero, J. Brek Eaton, Ekta Jaiswal, Sean B. Christensen, Joanna Gajewiak, Maren Watkins, Yiwei Cao, Baldomero M. Olivera, Wonpil Im, J.
Andrew A. George, Sabin J. John, Linda M. Lucero, J. Brek Eaton, Ekta Jaiswal, Sean B. Christensen, Joanna Gajewiak, Maren Watkins, Yiwei Cao, Baldomero M. Olivera, Wonpil Im, J. Michael McIntosh, Paul Whiteaker   +12 more
wiley   +1 more source

Allosteric α1-Adrenoreceptor Antagonism by the Conopeptide ρ-TIA [PDF]

Journal of Biological Chemistry, 2003
A peptide contained in the venom of the predatory marine snail Conus tulipa, rho-TIA, has previously been shown to possess alpha1-adrenoreceptor antagonist activity. Here, we further characterize its pharmacological activity as well as its structure-activity relationships.
Sharpe, Iain A., Thomas, Linda, Loughnan, Marion, Motin, Leonid, Palant, Elka, Croker, Daniel E., Alewood, Dianne, Chen, Songhai, Graham, Robert M., Alewood, Paul F., Adams, David J., Lewis, Richard J.   +11 more
openaire   +5 more sources

Identification, structural and pharmacological characterization of τ-CnVA, a conopeptide that selectively interacts with somatostatin sst3 receptor [PDF]

, 2013
Conopeptides are a diverse array of small linear and reticulated peptides that interact with high potency and selectivity with a large diversity of receptors and ion channels. They are used by cone snails for prey capture or defense.
Reynaud, M., NMR Spectroscopy, Sub NMR Spectroscopy, Hocking, H.G., Boelens, R., Servent, D., Petrel, C., et al., [No Value]   +7 more
core   +2 more sources

Venomics Reveals Venom Complexity of the Piscivorous Cone Snail, Conus tulipa

Marine Drugs, 2019
The piscivorous cone snail Conus tulipa has evolved a net-hunting strategy, akin to the deadly Conus geographus, and is considered the second most dangerous cone snail to humans. Here, we present the first venomics study of C.
Mriga Dutt, Sébastien Dutertre, Ai-Hua Jin, Vincent Lavergne, Paul Francis Alewood, Richard James Lewis   +5 more
doaj   +1 more source

Solution structures and thermodynamics of cis-trans X-Pro conformers of a novel single disulfide conopeptide

, 2023
710-728The conopeptide Mo1853 (MW = 1853 Da) consists of 17 residues and a single disulfide bond. Structural studies using homonuclear solution NMR methods (2D 1H,1H DQF-COSY, TOCSY, NOESY and ROESY spectra) revealed that Mo1853 exists as two equally ...
Kancherla, Aswani K, Sarma, Siddhartha P
core   +1 more source

Tyrosine-rich Conopeptides Affect Voltage-gated K+ Channels [PDF]

Journal of Biological Chemistry, 2008
Two venom peptides, CPY-Pl1 (EU000528) and CPY-Fe1 (EU000529), characterized from the vermivorous marine snails Conus planorbis and Conus ferrugineus, define a new class of conopeptides, the conopeptide Y (CPY) family. The peptides have no disulfide cross-links and are 30 amino acids long; the high content of tyrosine is unprecedented for any native ...
Imperial, Julita S., Chen, Ping, Sporning, Annett, Terlau, Heinrich, Daly, Norelle L., Craik, David J., Alewood, Paul F., Olivera, Baldormero M.   +7 more
openaire   +6 more sources

THE OMEGA CONOPEPTIDE TOXIN, LECONOTIDE, GIVEN INTRAVENOUSLY INCREASES MORPHINE ANTINOCICEPTION IN RAT PROSTATE BONE CANCER PAIN

, 2009
THE OMEGA CONOPEPTIDE TOXIN, LECONOTIDE, GIVEN INTRAVENOUSLY INCREASES MORPHINE ANTINOCICEPTION IN RAT PROSTATE BONE CANCER ...
L Aurini (21794609), A Kolosov (21794489), C Goodchild (17754279), E Williams (11760059), I Cooke (9618767)   +4 more
core  

Solution structure of χ-conopeptide MrIA, a modulator of the human norepinephrine transporter

, 2005
The chi-conopeptides MrIA and MrIB are 13-residue peptides with two disulfide bonds that inhibit human and rat norepinephrine transporter systems and are of significant interest for the design of novel drugs involved in pain treatment.
Lovelace, E. S., Caesar, C. E., Lewis, R. J., Sharpe, I. A., Tynngard, N., Johansson, H. M., Daly, N. L., Craik, D. J., Nilsson, K. P. R., Alewood, P. F.   +9 more
core   +1 more source