Results 71 to 80 of about 1,087 (186)

Excitation–contraction coupling inhibitors potentiate the actions of botulinum neurotoxin type A at the neuromuscular junction

British Journal of Pharmacology, Volume 182, Issue 3, Page 564-580, February 2025.
Abstract Background and Purpose Botulinum neurotoxin type A1 (BoNT/A) is one of the most potent neurotoxins known. At the same time, it is also one of the safest therapeutic agents used for the treatment of several human disorders and in aesthetic medicine.
Mickaël Machicoane, Marika Tonellato, Marica Zainotto, Paul Onillon, Marco Stazi, Mattia Dal Corso, Aram Megighian, Ornella Rossetto, Jean‐Marc Le Doussal, Marco Pirazzini   +9 more
wiley   +1 more source

[Retracted] A Showcase of Bench‐to‐Bedside Regenerative Medicine at the 2010 ASNTR

The Scientific World Journal, Volume 11, Issue 1, Page 1842-1864, 2011., 2011
Insight into the expanding themes of regenerative medicine is provided by the American Society for Neural Therapy and Repair′s annual meeting. The 17th meeting covered a wide range of neurodegenerative disorders, exploring methods to elucidate the currently unknown mechanisms behind the disorders, as well as possible treatments ranging from the use of ...
David J. Eve, Cesar V. Borlongan, Paul R. Sanberg, John Sladek   +3 more
wiley   +1 more source

Novel conopeptides of largely unexplored Indo Pacific Conus sp. [PDF]

, 2016
Cone snails are predatory creatures using venom as a weapon for prey capture and defense. Since this venom is neurotoxic, the venom gland is considered as an enormous collection of pharmacologically interesting compounds having a broad spectrum of ...
D'Souza, L., De Mot, R., Devi, P., Ghequire, M.G.K., Lebbe, E.K.M., Mille, B.G., Peigneur, S., Ravichandran, S., Tytgat, J., Waelkens, E.   +9 more
core  

Long-Term Effects of Botulinum Toxin Complex Type A Injection on Mechano-and Metabo-Sensitive Afferent Fibers Originating from Gastrocnemius Muscle [PDF]

, 2015
International audienceThe aim of the present study was to investigate long term effects of motor denervation by botulinum toxin complex type A (BoNT/A) from Clostridium Botulinum, on the afferent fibers originating from the gastrocnemius muscle of rats ...
Caron, Guillaume, Decherchi, Patrick, Marqueste, Tanguy   +2 more
core   +6 more sources

Prey specificity of predatory venoms

Biological Reviews, Volume 99, Issue 6, Page 2253-2273, December 2024.
ABSTRACT Venom represents a key adaptation of many venomous predators, allowing them to immobilise prey quickly through chemical rather than physical warfare. Evolutionary arms races between prey and a predator are believed to be the main factor influencing the potency and composition of predatory venoms.
Ondřej Michálek, Glenn F. King, Stano Pekár   +2 more
wiley   +1 more source

Venomics of Remipede Crustaceans Reveals Novel Peptide Diversity and Illuminates the Venom’s Biological Role [PDF]

, 2017
© 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Björn von Reumont, Dantuma, Eivind Undheim, Fry, Koenemann, Kuhn-Nentwig, Martin, Olesen, Robin-Tobias Jauss, Ronald Jenner, Runham, Schmidt, Schram, Schram, Von Reumont   +14 more
core   +1 more source

Mass Spectrometry-based Sequencing of Venom Peptides (Conotoxins) from Vermivorous Cone Snail, Conus Loroisii: Toxicity of its Natural Venom [PDF]

, 2021
Conus loroisii is a marine vermivorous snail found profusely in the southern seas of India. They harbor several toxic peptide components commonly called as ‘conotoxins’. In this study, we have identified and sequenced five conotoxins using proteome based
J, Arun Kumar, P, Rajesh R, R, Rishimol, Selvam, M Masilamani, Syed, Humaira Saleh   +4 more
core   +2 more sources

FDA's stamp of approval: Unveiling peptide breakthroughs in cardiovascular diseases, ACE, HIV, CNS, and beyond

Journal of Peptide Science, Volume 30, Issue 11, November 2024.
This review provides an overview of FDA‐approved peptides, particularly those targeting cardiovascular diseases, human immunodeficiency, and central nervous system diseases, and also addresses conditions such as osteoporosis, thrombocytopenia, Cushing's disease, and hypoglycemia.
Othman Al Musaimi
wiley   +1 more source

Conformational ensembles of non-peptide ω-conotoxin mimetics and Ca+2 ion binding to human voltage-gated N-type calcium channel Cav2.2

Computational and Structural Biotechnology Journal, 2020
Chronic neuropathic pain is the most complex and challenging clinical problem of a population that sets a major physical and economic burden at the global level. Ca2+-permeable channels functionally orchestrate the processing of pain signals. Among them,
Sameera, Fawad Ali Shah, Sajid Rashid
doaj   +1 more source

Purification and Characterization of the Pink-Floyd Drillipeptide, a Bioactive Venom Peptide fromClavus davidgilmouri (Gastropoda: Conoidea: Drilliidae)  [PDF]

, 2020
The cone snails (family Conidae) are the best known and most intensively studied venomous marine gastropods. However, of the total biodiversity of venomous marine mollusks (superfamily Conoidea, >20,000 species), cone snails comprise a minor fraction.
Carpio, Louie Paolo D., Chua, Victor M., Concepcion, Gisela P., Espino, Samuel S., Fedosov, Alexander, Gajewiak, Joanna, Imperial, Julita S., Olivera, Baldomero M., Omaga, Carla A., Ramiro, Iris Bea L., Safavi-Hemami, Helena, Salvador-Reyes, Lilibeth A., Watkins, Maren   +12 more
core   +2 more sources