Results 61 to 70 of about 771 (173)

A Benchmark Dataset Comprising Partition and Distribution Coefficients of Linear Peptides

Dataset Papers in Science, Volume 2013, Issue 1, 2013., 2013
Peptides have a dominant role in biology; yet the study of their physical properties is at best sporadic. Peptide quantitative structure‐activity relationship (QSAR) lags far behind the QSAR analysis of drug‐like organic small molecules. Traditionally, QSAR has focussed on experimentally determined partition coefficients as the main descriptor of ...
Matthew N. Davies, Darren R. Flower, Liam McGuffin, Luis Alberto Ponce Soto   +3 more
wiley   +1 more source

Novel Conopeptides of Largely Unexplored Indo Pacific Conus sp.

Marine Drugs, 2016
Cone snails are predatory creatures using venom as a weapon for prey capture and defense. Since this venom is neurotoxic, the venom gland is considered as an enormous collection of pharmacologically interesting compounds having a broad spectrum of ...
Eline K. M. Lebbe, Maarten G. K. Ghequire, Steve Peigneur, Bea G. Mille, Prabha Devi, Samuthirapandian Ravichandran, Etienne Waelkens, Lisette D’Souza, René De Mot, Jan Tytgat   +9 more
doaj   +1 more source

Excitation–contraction coupling inhibitors potentiate the actions of botulinum neurotoxin type A at the neuromuscular junction

British Journal of Pharmacology, Volume 182, Issue 3, Page 564-580, February 2025.
Abstract Background and Purpose Botulinum neurotoxin type A1 (BoNT/A) is one of the most potent neurotoxins known. At the same time, it is also one of the safest therapeutic agents used for the treatment of several human disorders and in aesthetic medicine.
Mickaël Machicoane, Marika Tonellato, Marica Zainotto, Paul Onillon, Marco Stazi, Mattia Dal Corso, Aram Megighian, Ornella Rossetto, Jean‐Marc Le Doussal, Marco Pirazzini   +9 more
wiley   +1 more source

[Retracted] A Showcase of Bench‐to‐Bedside Regenerative Medicine at the 2010 ASNTR

The Scientific World Journal, Volume 11, Issue 1, Page 1842-1864, 2011., 2011
Insight into the expanding themes of regenerative medicine is provided by the American Society for Neural Therapy and Repair′s annual meeting. The 17th meeting covered a wide range of neurodegenerative disorders, exploring methods to elucidate the currently unknown mechanisms behind the disorders, as well as possible treatments ranging from the use of ...
David J. Eve, Cesar V. Borlongan, Paul R. Sanberg, John Sladek   +3 more
wiley   +1 more source

Prey specificity of predatory venoms

Biological Reviews, Volume 99, Issue 6, Page 2253-2273, December 2024.
ABSTRACT Venom represents a key adaptation of many venomous predators, allowing them to immobilise prey quickly through chemical rather than physical warfare. Evolutionary arms races between prey and a predator are believed to be the main factor influencing the potency and composition of predatory venoms.
Ondřej Michálek, Glenn F. King, Stano Pekár   +2 more
wiley   +1 more source

Structural features of conopeptide genes inferred from partial sequences of the Conus tribblei genome

, 2016
The evolvability of venom components (in particular, the gene-encoded peptide toxins) in venomous species serves as an adaptive strategy allowing them to target new prey types or respond to changes in the prey field.
Barghi, N. ; https://orcid.org/, Concepcion, G., Olivera, B., Lluisma, A.   +3 more
core   +1 more source

Conopeptide-derived κ-opioid agonists (conorphins): potent, selective, and metabolic stable dynorphin a mimetics with antinociceptive properties [PDF]

, 2016
Opioid receptor screening of a conopeptide library led to a novel selective κ-opioid agonist peptide (conorphin T). Intensive medicinal chemistry, guided by potency, selectivity, and stability assays generated a pharmacophore model supporting rational ...
Andersson, Asa, Ragnarsson, Lotten K. N., Brust, Andreas, Lotten Ragnarsson, Garcia-Caraballo, Sonia, Kapil Jain, Åsa Andersson, Paul F. Alewood (1520788), Jain, Kapil, Croker, Daniel E, Colless, B., Sonia Garcia-Caraballo (2143672), Ragnarsson, Lotten, Barbara Colless (30800), Sonia Garcia-Caraballo, Castro, Joel, Joel Castro, Castro, J., Lewis, Richard J., Lotten Ragnarsson (394253), Richard J. Lewis (30801), Croker, D., Andreas Brust, Kapil Jain (2143666), Brierley, Stuart M, Brierley, Stuart M., Alewood, Paul F., Daniel E. Croker, Stuart M Brierley, Åsa Andersson (63846), Barbara Colless, Croker, Daniel, Jain, K., Stuart M Brierley (2143663), Garcia-Caraballo, S., Richard J. Lewis, Colless, Barbara, Andersson, Å., Ragnarsson, L., Joel Castro (2143660), Brierley, S., Alewood, P., Paul F. Alewood, Lewis, Richard J, Daniel E. Croker (2143669), Lewis, R., Alewood, Paul F, Brust, A., Andreas Brust (30799)   +48 more
core   +1 more source

FDA's stamp of approval: Unveiling peptide breakthroughs in cardiovascular diseases, ACE, HIV, CNS, and beyond

Journal of Peptide Science, Volume 30, Issue 11, November 2024.
This review provides an overview of FDA‐approved peptides, particularly those targeting cardiovascular diseases, human immunodeficiency, and central nervous system diseases, and also addresses conditions such as osteoporosis, thrombocytopenia, Cushing's disease, and hypoglycemia.
Othman Al Musaimi
wiley   +1 more source

χ-conopeptide MrIA partially overlaps desipramine and cocaine binding sites on the human norepinephrine transporter [PDF]

, 2003
The interactions of chi-conopeptide MrIA with the human norepinephrine transporter (hNET) were investigated by determining the effects of hNET point mutations on the inhibitory potency of MrIA.
Lewis, Richard J., Bryan-Lluka, Lesley J., Bonisch, Heinz   +2 more
core   +1 more source

Conformational ensembles of non-peptide ω-conotoxin mimetics and Ca+2 ion binding to human voltage-gated N-type calcium channel Cav2.2

Computational and Structural Biotechnology Journal, 2020
Chronic neuropathic pain is the most complex and challenging clinical problem of a population that sets a major physical and economic burden at the global level. Ca2+-permeable channels functionally orchestrate the processing of pain signals. Among them,
Sameera, Fawad Ali Shah, Sajid Rashid
doaj   +1 more source