Results 61 to 70 of about 1,087 (186)

Allosteric α1-Adrenoreceptor Antagonism by the Conopeptide ρ-TIA [PDF]

Journal of Biological Chemistry, 2003
A peptide contained in the venom of the predatory marine snail Conus tulipa, rho-TIA, has previously been shown to possess alpha1-adrenoreceptor antagonist activity. Here, we further characterize its pharmacological activity as well as its structure-activity relationships.
Sharpe, Iain A., Thomas, Linda, Loughnan, Marion, Motin, Leonid, Palant, Elka, Croker, Daniel E., Alewood, Dianne, Chen, Songhai, Graham, Robert M., Alewood, Paul F., Adams, David J., Lewis, Richard J.   +11 more
openaire   +3 more sources

A novel inhibitor of α9α10 nicotinic acetylcholine receptors from Conus vexillum delineates a new conotoxin superfamily. [PDF]

PLoS ONE, 2013
Conotoxins (CTxs) selectively target a range of ion channels and receptors, making them widely used tools for probing nervous system function. Conotoxins have been previously grouped into superfamilies according to signal sequence and into families based
Sulan Luo, Sean Christensen, Dongting Zhangsun, Yong Wu, Yuanyan Hu, Xiaopeng Zhu, Sandeep Chhabra, Raymond S Norton, J Michael McIntosh   +8 more
doaj   +1 more source

The M-Superfamily of Conotoxins: A Review [PDF]

, 2010
Throughout the world there exist both predator and prey. This distinction is apparent though sometimes misleading. Take for example marine snails of the genus Conus that are present across the oceans of the southern hemisphere [1].
Jacob, Reed B., McDougal, Owen M.
core   +2 more sources

Analysis of venom gland transcriptomes from two Tesseliconus species, Conus eburneus and Conus tessulatus, reveals inter- and intra-specific variations in conopeptide diversity and expression as well as putative novel gene superfamilies and disulfide-poor venom components

Frontiers in Marine Science
The Conus subgenus Tesseliconus, whose members are believed to be primarily worm-hunters, phylogenetically clusters closely with piscivorous groups relative to most other vermivorous subgenera. A previous study even documented the Tesseliconus species C.
Francis A. Tablizo, Francis A. Tablizo, Dan Jethro M. Masacupan, Dan Jethro M. Masacupan, Arturo O. Lluisma   +4 more
doaj   +1 more source

Antimycobacterial Activity: A New Pharmacological Target for Conotoxins Found in the First Reported Conotoxin from Conasprella ximenes

Toxins, 2018
Mycobacterium tuberculosis is the etiological agent of tuberculosis, an airborne infectious disease that is a leading cause of human morbidity and mortality worldwide.
Andrea Figueroa-Montiel, Johanna Bernáldez, Samanta Jiménez, Beatrix Ueberhide, Luis Javier González, Alexei Licea-Navarro   +5 more
doaj   +1 more source

α‐RgIB: A Novel Antagonist Peptide of Neuronal Acetylcholine Receptor Isolated from Conus regius Venom

International Journal of Peptides, Volume 2013, Issue 1, 2013., 2013
Conus venoms are rich sources of biologically active peptides that act specifically on ionic channels and metabotropic receptors present at the neuromuscular junction, efficiently paralyzing the prey. Each species of Conus may have 50 to 200 uncharacterized bioactive peptides with pharmacological interest.
Maria Cristina Vianna Braga, Arthur Andrade Nery, Henning Ulrich, Katsuhiro Konno, Juliana Mozer Sciani, Daniel Carvalho Pimenta, Ayman El-Faham   +6 more
wiley   +1 more source

Overexpression, purification, and pharmacological activity of a biosynthetically derived conopeptide [PDF]

Biochemical and Biophysical Research Communications, 2005
A high yielding fusion protein system based on the protein cytochrome b(5) has been used for the production of novel 13-residue acyclic conopeptide. This peptide, Mo1659, can be liberated from the carrier protein using CNBr cleavage and subsequent purification using RP-HPLC methods. The yield of isotopically enriched peptides is high, ranging from 3 to
Kumar, Ganesan Senthil, Ramasamy, Palanisamy, Sikdar, Sujit K, Sarma, Siddhartha P   +3 more
openaire   +3 more sources

TRUFA: A user-friendly web server for de novo RNA-seq analysis using cluster computing. [PDF]

, 2016
Application of next-generation sequencing (NGS) methods for transcriptome analysis (RNA-seq) has become increasingly accessible in recent years and are of great interest to many biological disciplines including, eg, evolutionary biology, ecology ...
Aguilar, Fernando, Cabellos, Luis, Frías-López, Cristina, Kornobis, Etienne, Marco, Jesús, Rozas Liras, Julio A., Zardoya, Rafael   +6 more
core   +1 more source

A Benchmark Dataset Comprising Partition and Distribution Coefficients of Linear Peptides

Dataset Papers in Science, Volume 2013, Issue 1, 2013., 2013
Peptides have a dominant role in biology; yet the study of their physical properties is at best sporadic. Peptide quantitative structure‐activity relationship (QSAR) lags far behind the QSAR analysis of drug‐like organic small molecules. Traditionally, QSAR has focussed on experimentally determined partition coefficients as the main descriptor of ...
Matthew N. Davies, Darren R. Flower, Liam McGuffin, Luis Alberto Ponce Soto   +3 more
wiley   +1 more source

Mechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine receptor [PDF]

, 2014
Background: Selective and potent positive allosteric modulators (PAMs) of the M1 mAChR have been recently described. Results: Use of structural analogues and mutagenic mapping identified the mechanistic basis for increased PAM activity.
Abdul-Ridha, Byun, Canals, Christopoulos, Conn, Conn, Dror, Foster, Haga, Hulme, Jones, Katritch, Kenakin, Kennedy, Keov, Kruse, Kruse, Kruse, Kuduk, Kuduk, Kuduk, Lazareno, Leach, Leach, Lebois, Lebon, Ma, Matsui, May, Melancon, Mistry, Motulsky, Nathan, Nawaratne, Nickols, Phillips, Ragnarsson, Shirey, Shonberg, Stevens, Tarr, Valant, Venkatakrishnan   +42 more
core   +2 more sources