Results 41 to 50 of about 771 (173)

ConoMode, a database for conopeptide binding modes

Database, 2020
Abstract ConoMode is a database for complex three-dimensional (3D) structures of conopeptides binding with their target proteins. Conopeptides, a large family of peptides from the venom of marine snails of the Conus genus, have exceptionally diverse sequences, and their high specificity to block ion channels makes them crucial as drug ...
Xiao Li, Hao Liu 0045, Chunxiao Gao, Yangyang Li, Dongning Jia, Yanbo Yang, Jinbo Yang, Zhiqiang Wei 0002, Tao Jiang 0057, Rilei Yu   +9 more
openaire   +2 more sources

Conopeptide-Functionalized Nanoparticles Selectively Antagonize Extrasynaptic N‑Methyl‑d‑aspartate Receptors and Protect Hippocampal Neurons from Excitotoxicity In Vitro

, 2020
N-methyl-d-aspartate receptors (NMDARs) are ionotropic glutamate receptors controlling fundamental physiological processes in the central nervous system, such as learning and memory.
Pierluigi Valente (172927), Claire M. Cobley (2045842), Roland A. Fleck (7381181), Vincenzo Mangini (6384221), Darya Kiryushko (7424477), Silvio Sacchetti (2866274), Alexandra E. Porter (828025), Joachim P. Spatz (112990), Fabio Benfenati (172964), Pedro Machado (3435023), Roberto Fiammengo (25483)   +10 more
core   +1 more source

Engineered biosynthesis of cyclotides

New Zealand Journal of Botany, Volume 58, Issue 4, Page 358-377, December 2020., 2020
ABSTRACT A system based on cyanobacterial split inteins, SICLOPPs (Split Intein Circular Ligation of Proteins and Peptides), has been used to synthesise a small natively cyclic plant protein, kalata B1, and cyclised versions of the natively linear therapeutic peptides ziconotide and leconotide.
Thomas N. G. Handley, Hyon‐Xhi Tan, Malcolm T. Rutledge, Hans Henning Brewitz, Joel D. A. Tyndall, Torsten Kleffmann, Margi I. Butler, Russell T. M. Poulter, Sigurd M. Wilbanks   +8 more
wiley   +1 more source

High conopeptide diversity in Conus striatus: Revealed by integration of two transcriptome sequencing platforms

Frontiers in Marine Science, 2022
Marine cone snail venoms represent a vast library of bioactive peptides with proven potential as research tools, drug leads, and therapeutics. In this study, a transcriptome library of four different organs, namely radular sheath, venom duct, venom gland,
Yanling Liao, Chao Peng, Chao Peng, Yabing Zhu, Jinxing Fu, Zhiqiang Ruan, Qiong Shi, Qiong Shi, Bingmiao Gao   +8 more
doaj   +1 more source

Hormone-like conopeptides - new tools for pharmaceutical design. [PDF]

RSC Med Chem, 2020
Marine cone snails produce an array of hormone-like peptides in their venom, providing bioactive leads for developing peptide drugs and small molecule mimetics.
Turner A, Kaas Q, Craik DJ.
europepmc   +7 more sources

ConoServer: updated content, knowledge, and discovery tools in the conopeptide database [PDF]

, 2011
International audienceConoServer (http://www.conoserver.org) is a database specializing in the sequences and structures of conopeptides, which are toxins expressed by marine cone snails. Cone snails are carnivorous gastropods, which hunt their prey using
Kaas, Quentin, Jin, Ai-Hua, Q. Kaas, A.-H. Jin, Dutertre, Sébastien, R. Yu, Craik, David,, S. Dutertre, D. J. Craik, Yu, Rilei   +9 more
core   +1 more source

Discovery of 194 Unreported Conopeptides and Identification of a New Protein Disulfide Isomerase in Conus caracteristicus Using Integrated Transcriptomic and Proteomic Analysis

Frontiers in Marine Science, 2022
Current ConoServer database accumulates 8,134 conopeptides from 122 species of cone snail, which are pharmaceutically attractive marine resource. However, many more conopeptides remain to be discovered, and the enzymes involved in their synthesis and ...
Han Zhang, Han Zhang, Han Zhang, Lei Wang, Yinbin Qiu, Yinbin Qiu, Yinbin Qiu, Fahui Gong, Baoting Nong, Xinghua Pan, Xinghua Pan, Xinghua Pan   +11 more
doaj   +1 more source

Conopeptide-functionalized nanoparticles selectively antagonize extrasynaptic n-methyl-d-aspartate receptors and protect hippocampal neurons from excitotoxicity in vitro

, 2020
N-methyl-d-aspartate receptors (NMDARs) are ionotropic glutamate receptors controlling fundamental physiological processes in the central nervous system, such as learning and memory.
Cobley, C. M., Porter, A., Machado, P., Fleck, R., Cobley, C., Fiammengo, R., Sacchetti, S., Valente, P., Kiryushko, D., Porter, A. E., Spatz, J., Fleck, R. A., Spatz, J. P., Mangini, V., Benfenati, F.   +14 more
core   +2 more sources

Transcriptomic-Proteomic Correlation in the Predation-Evoked Venom of the Cone Snail, Conus imperialis

Marine Drugs, 2019
Individual variation in animal venom has been linked to geographical location, feeding habit, season, size, and gender. Uniquely, cone snails possess the remarkable ability to change venom composition in response to predatory or defensive stimuli.
Ai-Hua Jin, Sébastien Dutertre, Mriga Dutt, Vincent Lavergne, Alun Jones, Richard J. Lewis, Paul F. Alewood   +6 more
doaj   +1 more source

Conotoxins: Therapeutic Potential and Application

Marine Drugs, 2006
The pharmacological variety of conotoxins, diverse peptides found in the venoms of marine cone snails, is well recognized. Venoms from each of the estimated 500 species of cone snails contain 50 to 200 distinct biologically active peptides.
Richard T. Layer, J. Michael McIntosh
doaj   +1 more source