Results 41 to 50 of about 1,087 (186)

Conotoxin Gene Superfamilies

Marine Drugs, 2014
Conotoxins are the peptidic components of the venoms of marine cone snails (genus Conus). They are remarkably diverse in terms of structure and function. Unique potency and selectivity profiles for a range of neuronal targets have made several conotoxins
Samuel D. Robinson, Raymond S. Norton
doaj   +1 more source

Diversity of Conopeptides and Their Precursor Genes of Conus Litteratus. [PDF]

Mar Drugs, 2020
The venom of various Conus species is composed of a rich variety of unique bioactive peptides, commonly referred to as conotoxins (conopeptides). Most conopeptides have specific receptors or ion channels as physiologically relevant targets. In this paper, high-throughput transcriptome sequencing was performed to analyze putative conotoxin transcripts ...
Li X, Chen W, Zhangsun D, Luo S.
europepmc   +5 more sources

Novel conopeptides of the I-superfamily occur in several clades of cone snails [PDF]

, 2004
The I-superfamily of conotoxins represents a new class of peptides in the venom of some Conus species. These toxins are characterized by four disulfide bridges and inhibit or modify ion channels of nerve cells.
Huys, I., Kauferstein, S., Kuch, U., Mebs, D., Melaun, C., Tytgat, J.   +5 more
core   +1 more source

ConoServer, a database for conopeptide sequences and structures [PDF]

Bioinformatics, 2007
Abstract Summary: ConoServer is a new database dedicated to conopeptides, a large family of peptides found in the venom of marine snails of the genus Conus. These peptides have an exceptional diversity of sequences and chemical modifications and their ability to block ion channels makes them important as drug leads and tools for ...
Kaas, Quentin, Westermann, Jan, Halai, Reena, Wang, Conan, Craik, David J.   +4 more
openaire   +3 more sources

Stabilization of α-conotoxin AuIB: Influences of disulfide connectivity and backbone cyclization [PDF]

, 2011
alpha-Conotoxins are peptides isolated from the venom ducts of cone snails that target nicotinic acetylcholine receptors (nAChRs). They are valuable pharmacological tools and have potential applications for treating a range of conditions in humans ...
Anton A. Grishin, Charlotta Alvarmo, David J. Adams, David J. Craik, Dwoskin LP, Erica S. Lovelace, Norelle L. Daly, Richard J. Clark, Simon T. Nevin, Sunithi Gunasekera, Wüthrich K   +10 more
core   +1 more source

A marine analgesic peptide, Contulakin-G, and neurotensin are distinct agonists for neurotensin receptors: uncovering structural determinants of desensitization properties [PDF]

, 2015
Neurotensin receptors have been studied as molecular targets for the treatment of pain, schizophrenia, addiction, or cancer. Neurotensin (NT) and Contulakin-G, a glycopeptide isolated from a predatory cone snail Conus geographus, share a sequence ...
Aleksandra eWalewska, Aleksandra eWalewska, Baldomero M Olivera, Grzegorz eBulaj, H Steve eWhite, Hee-Kyoung eLee, J Michael eMcIntosh, Liuyin eZhang, Misty D Smith, Nadeem eVellore, Riccardo eBaron   +10 more
core   +2 more sources

Reply to Comment on Conopeptide-Functionalized Nanoparticles Selectively Antagonize Extrasynaptic N-Methyl-d-aspartate Receptors and Protect Hippocampal Neurons from Excitotoxicity In Vitro [PDF]

, 2021
In this manuscript, we provide precise answers to the concerns expressed by Molokanova et al. in their comment. In our reply, we highlight that there is indeed substantial agreement between our study and the one reported in Nano Letters by the Molokanova’
Benfenati, Fabio, Cobley, Claire M., Fiammengo, Roberto, Fleck, Roland A., Kiryushko, Darya, Machado, Pedro, Mangini, Vincenzo, Porter, Alexandra E., Sacchetti, Silvio, Spatz, Joachim P., Valente, Pierluigi   +10 more
core   +1 more source

Engineered biosynthesis of cyclotides

New Zealand Journal of Botany, Volume 58, Issue 4, Page 358-377, December 2020., 2020
ABSTRACT A system based on cyanobacterial split inteins, SICLOPPs (Split Intein Circular Ligation of Proteins and Peptides), has been used to synthesise a small natively cyclic plant protein, kalata B1, and cyclised versions of the natively linear therapeutic peptides ziconotide and leconotide.
Thomas N. G. Handley, Hyon‐Xhi Tan, Malcolm T. Rutledge, Hans Henning Brewitz, Joel D. A. Tyndall, Torsten Kleffmann, Margi I. Butler, Russell T. M. Poulter, Sigurd M. Wilbanks   +8 more
wiley   +1 more source

High conopeptide diversity in Conus striatus: Revealed by integration of two transcriptome sequencing platforms

Frontiers in Marine Science, 2022
Marine cone snail venoms represent a vast library of bioactive peptides with proven potential as research tools, drug leads, and therapeutics. In this study, a transcriptome library of four different organs, namely radular sheath, venom duct, venom gland,
Yanling Liao, Chao Peng, Chao Peng, Yabing Zhu, Jinxing Fu, Zhiqiang Ruan, Qiong Shi, Qiong Shi, Bingmiao Gao   +8 more
doaj   +1 more source

Discovery of 194 Unreported Conopeptides and Identification of a New Protein Disulfide Isomerase in Conus caracteristicus Using Integrated Transcriptomic and Proteomic Analysis

Frontiers in Marine Science, 2022
Current ConoServer database accumulates 8,134 conopeptides from 122 species of cone snail, which are pharmaceutically attractive marine resource. However, many more conopeptides remain to be discovered, and the enzymes involved in their synthesis and ...
Han Zhang, Han Zhang, Han Zhang, Lei Wang, Yinbin Qiu, Yinbin Qiu, Yinbin Qiu, Fahui Gong, Baoting Nong, Xinghua Pan, Xinghua Pan, Xinghua Pan   +11 more
doaj   +1 more source