Snails In Silico: A Review of Computational Studies on the Conopeptides [PDF]
Marine Drugs, 2019 Marine cone snails are carnivorous gastropods that use peptide toxins called conopeptides both as a defense mechanism and as a means to immobilize and kill their prey.
Jeanne M Fair +2 more
exaly +6 more sources
High-Throughput Prediction and Design of Novel Conopeptides for Biomedical Research and Development [PDF]
BioDesign Research, 2022 Cone snail venoms have been considered a valuable treasure for international scientists and businessmen, mainly due to their pharmacological applications in development of marine drugs for treatment of various human diseases.
Bingmiao Gao +7 more
doaj +3 more sources
Usage of Cell-Free Protein Synthesis in Post-Translational Modification of μ-Conopeptide PIIIA [PDF]
Marine Drugs, 2023 The post-translational modifications of conopeptides are the most complicated modifications to date and are well-known and closely related to the activity of conopeptides.
Yanli Liu +5 more
doaj +2 more sources
Bibliometric Review of the Literature on Cone Snail Peptide Toxins from 2000 to 2022 [PDF]
Marine Drugs, 2023 The venom of marine cone snails is mainly composed of peptide toxins called conopeptides, among which conotoxins represent those that are disulfide-rich.
Linh T. T. Nguyen +2 more
doaj +2 more sources
Cone snail species off the Brazilian coast and their venoms: a review and update [PDF]
Journal of Venomous Animals and Toxins including Tropical Diseases, 2023 The genus Conus includes over 900 species of marine invertebrates known as cone snails, whose venoms are among the most powerful described so far.
Helena B. Fiorotti +3 more
doaj +2 more sources
Frontiers in Marine Science, 2021 Conopeptides from the marine cone snails are a mixture of cysteine-rich active peptides, representing a unique and fertile resource for neuroscience research and drug discovery.
Xinghua Pan
exaly +3 more sources
Proteomic analysis of Red Sea Conus taeniatus venom reveals potential biological applications [PDF]
Journal of Venomous Animals and Toxins including Tropical Diseases, 2021 Background: Diverse and unique bioactive neurotoxins known as conopeptides or conotoxins are produced by venomous marine cone snails. Currently, these small and stable molecules are of great importance as research tools and platforms for discovering new ...
Maged M. A. Fouda +4 more
doaj +2 more sources
Deep learning-driven discovery and mechanism of action study of a minimalist conopeptide targeting α7 nicotinic acetylcholine receptor [PDF]
Acta Pharmaceutica Sinica BDespite extensive structural and functional characterization of the α7 nicotinic acetylcholine receptor, valuable structural insights into its interactions with conopeptides remain limited, thereby hindering the rational development of peptide-based ...
Jinghui Zhang +9 more
doaj +2 more sources
Frontiers in Marine Science, 2022 Current ConoServer database accumulates 8,134 conopeptides from 122 species of cone snail, which are pharmaceutically attractive marine resource. However, many more conopeptides remain to be discovered, and the enzymes involved in their synthesis and ...
Xinghua Pan
exaly +3 more sources
Diversity and Novelty of Venom Peptides in Vermivorous Cone Snails, Subgenus Rhizoconus (Gastropoda: Mollusca) [PDF]
Marine DrugsA large majority of cone snails (a species in the genus Conus) are vermivorous (worm-hunting), but the diversity and bioactivity of their venom peptides remain largely unexplored.
Christine Marie C. Florece +3 more
doaj +2 more sources