Results 41 to 50 of about 849 (177)

Non-Peptidic Small Molecule Components from Cone Snail Venoms

Frontiers in Pharmacology, 2021
Venomous molluscs (Superfamily Conoidea) comprise a substantial fraction of tropical marine biodiversity (>15,000 species). Prior characterization of cone snail venoms established that bioactive venom components used to capture prey, defend against ...
Zhenjian Lin, Joshua P. Torres, Maren Watkins, Noemi Paguigan, Changshan Niu, Julita S. Imperial, Jortan Tun, Helena Safavi-Hemami, Helena Safavi-Hemami, Rocio K. Finol-Urdaneta, Jorge L. B. Neves, Samuel Espino, Manju Karthikeyan, Baldomero M. Olivera, Eric W. Schmidt   +14 more
doaj   +1 more source

Synthesis and evaluation of a novel analgesic conotoxin Lt7b that inhibits calcium currents and increases sodium currents

Journal of Cellular and Molecular Medicine, Volume 26, Issue 20, Page 5330-5334, October 2022., 2022
Abstract Conotoxins are promising neuropharmacological tools and drug candidates due to their high efficiency and specificity in targeting ion channels or neurotransmitter receptors. In this study, a novel O2‐superfamily conotoxin, Lt7b, was synthesized and its pharmacological functions were evaluated.
Yun Wu, Manyi Yang, Yubin Li, Wei Zhang, Maojun Zhou   +4 more
wiley   +1 more source

Discovery of KV1.3 ion channel inhibitors: Medicinal chemistry approaches and challenges

Medicinal Research Reviews, Volume 41, Issue 4, Page 2423-2473, July 2021., 2021
Abstract The KV1.3 voltage‐gated potassium ion channel is involved in many physiological processes both at the plasma membrane and in the mitochondria, chiefly in the immune and nervous systems. Therapeutic targeting KV1.3 with specific peptides and small molecule inhibitors shows great potential for treating cancers and autoimmune diseases, such as ...
Špela Gubič, Louise A. Hendrickx, Žan Toplak, Maša Sterle, Steve Peigneur, Tihomir Tomašič, Luis A. Pardo, Jan Tytgat, Anamarija Zega, Lucija P. Mašič   +9 more
wiley   +1 more source

ConoDictor: a tool for prediction of conopeptide superfamilies [PDF]

Nucleic Acids Research, 2012
ConoDictor is a tool that enables fast and accurate classification of conopeptides into superfamilies based on their amino acid sequence. ConoDictor combines predictions from two complementary approaches-profile hidden Markov models and generalized profiles. Results appear in a browser as tables that can be downloaded in various formats.
Dominique Koua, Age Brauer, Silja Laht, Lauris Kaplinski, Philippe Favreau, Maido Remm, Frédérique Lisacek, Reto Stöcklin   +7 more
openaire   +3 more sources

Isolation and characterization of five novel disulfide-poor conopeptides from Conus marmoreus venom

, 2022
Background: Conopeptides from cone snail venom have aroused great interest related to the discovery of novel bioactive candidates, due to their excellent prospects for the treatment of various health problems such as pain, addiction, psychosis and ...
Shuang Ju (12652754), Yu Zhang (12946), Ying Fu (173963), Sulan Luo (277905), Wenwen Huang (327269), Bokai Ma (12652757)   +5 more
core   +1 more source

ConoServer, a database for conopeptide sequences and structures [PDF]

Bioinformatics, 2007
Abstract Summary: ConoServer is a new database dedicated to conopeptides, a large family of peptides found in the venom of marine snails of the genus Conus. These peptides have an exceptional diversity of sequences and chemical modifications and their ability to block ion channels makes them important as drug leads and tools for ...
Quentin Kaas, Jan-C. Westermann, Reena Halai, Conan K. L. Wang, David J. Craik   +4 more
openaire   +5 more sources

Two new classes of conopeptides inhibit the alpha 1-adrenoceptor and noradrenaline transporter [PDF]

, 2001
Cone snails use venom containing a cocktail of peptides ('conopeptides') to capture their prey. Many of these peptides also target mammalian receptors, often with exquisite selectivity. Here we report the discovery of two new classes of conopeptides. One
Palant, E., Alewood, Paul F., Thomas, L., Sharpe, I. A., Loughnan, M. L., Craik, D. J., Alewood, P. F., Elka Palant, Iain A. Sharpe, Adams, D. J., Adams, David J, Lewis, R. J., David J. Craik, Sharpe, Iain A., John Gehrmann, Adams, Denise A., Denise A. Adams, Richard J. Lewis, Ann Atkins, Atkins, Ann, Marion L. Loughnan, Linda Thomas, David J. Adams, Atkins, A., Loughnan, Marion L., Thomas, Linda, Craik, David J., Gehrmann, John, Lewis, Richard J., Paul F. Alewood, Gehrmann, J., Adams, D. A., Palant, Elka   +32 more
core   +2 more sources

Mechanisms for Evolving Hypervariability: The Case of Conopeptides [PDF]

Molecular Biology and Evolution, 2001
Hypervariability is a prominent feature of large gene families that mediate interactions between organisms, such as venom-derived toxins or immunoglobulins. In order to study mechanisms for evolution of hypervariability, we examined an EST-generated assemblage of 170 distinct conopeptide sequences from the venoms of five species of marine Conus snails.
S G, Conticello, Y, Gilad, N, Avidan, E, Ben-Asher, Z, Levy, M, Fainzilber   +5 more
openaire   +2 more sources

Data_Sheet_2_Identification of Novel Conopeptides and Distinct Gene Superfamilies in the Marine Cone Snail Conus quercinus.doc

, 2021
Conopeptides from the marine cone snails are a mixture of cysteine-rich active peptides, representing a unique and fertile resource for neuroscience research and drug discovery.
Han Zhang (110653), Lei Wang (6656), Zhiwei Lian (11501509), Yinbin Qiu (11501506), Zhanying Dong (11555315), Xuedong Wu (1471993), Xinghua Pan (3663958), Xiang Yang (223219)   +7 more
core   +1 more source

ConoMode, a database for conopeptide binding modes

Database, 2020
Abstract ConoMode is a database for complex three-dimensional (3D) structures of conopeptides binding with their target proteins. Conopeptides, a large family of peptides from the venom of marine snails of the Conus genus, have exceptionally diverse sequences, and their high specificity to block ion channels makes them crucial as drug ...
Xiao Li, Hao Liu 0045, Chunxiao Gao, Yangyang Li, Dongning Jia, Yanbo Yang, Jinbo Yang, Zhiqiang Wei 0002, Tao Jiang 0057, Rilei Yu   +9 more
openaire   +2 more sources