Results 61 to 70 of about 849 (177)

Table_3_Discovery of 194 Unreported Conopeptides and Identification of a New Protein Disulfide Isomerase in Conus caracteristicus Using Integrated Transcriptomic and Proteomic Analysis.xlsx

, 2022
Current ConoServer database accumulates 8,134 conopeptides from 122 species of cone snail, which are pharmaceutically attractive marine resource. However, many more conopeptides remain to be discovered, and the enzymes involved in their synthesis and ...
Han Zhang (110653), Lei Wang (6656), Fahui Gong (12162821), Baoting Nong (8652468), Yinbin Qiu (11501506), Xinghua Pan (3663958)   +5 more
core   +1 more source

Molecular Phylogeny, Classification and Evolution of Conopeptides [PDF]

, 2018
Conopeptides are toxins expressed in the venom duct of cone snails (Conoidea, Conus). These are mostly well-structured peptides and mini-proteins with high potency and selectivity for a broad range of cellular targets.
Koua, D., Puillandre, N., Stöcklin, R., Favreau, P., Olivera, B.   +4 more
core  

Excitation–contraction coupling inhibitors potentiate the actions of botulinum neurotoxin type A at the neuromuscular junction

British Journal of Pharmacology, Volume 182, Issue 3, Page 564-580, February 2025.
Abstract Background and Purpose Botulinum neurotoxin type A1 (BoNT/A) is one of the most potent neurotoxins known. At the same time, it is also one of the safest therapeutic agents used for the treatment of several human disorders and in aesthetic medicine.
Mickaël Machicoane, Marika Tonellato, Marica Zainotto, Paul Onillon, Marco Stazi, Mattia Dal Corso, Aram Megighian, Ornella Rossetto, Jean‐Marc Le Doussal, Marco Pirazzini   +9 more
wiley   +1 more source

[Retracted] A Showcase of Bench‐to‐Bedside Regenerative Medicine at the 2010 ASNTR

The Scientific World Journal, Volume 11, Issue 1, Page 1842-1864, 2011., 2011
Insight into the expanding themes of regenerative medicine is provided by the American Society for Neural Therapy and Repair′s annual meeting. The 17th meeting covered a wide range of neurodegenerative disorders, exploring methods to elucidate the currently unknown mechanisms behind the disorders, as well as possible treatments ranging from the use of ...
David J. Eve, Cesar V. Borlongan, Paul R. Sanberg, John Sladek   +3 more
wiley   +1 more source

Data_Sheet_1_Discovery of 194 Unreported Conopeptides and Identification of a New Protein Disulfide Isomerase in Conus caracteristicus Using Integrated Transcriptomic and Proteomic Analysis.docx

, 2022
Current ConoServer database accumulates 8,134 conopeptides from 122 species of cone snail, which are pharmaceutically attractive marine resource. However, many more conopeptides remain to be discovered, and the enzymes involved in their synthesis and ...
Han Zhang (110653), Lei Wang (6656), Fahui Gong (12162821), Baoting Nong (8652468), Yinbin Qiu (11501506), Xinghua Pan (3663958)   +5 more
core   +1 more source

Prey specificity of predatory venoms

Biological Reviews, Volume 99, Issue 6, Page 2253-2273, December 2024.
ABSTRACT Venom represents a key adaptation of many venomous predators, allowing them to immobilise prey quickly through chemical rather than physical warfare. Evolutionary arms races between prey and a predator are believed to be the main factor influencing the potency and composition of predatory venoms.
Ondřej Michálek, Glenn F. King, Stano Pekár   +2 more
wiley   +1 more source

Table_2_Discovery of 194 Unreported Conopeptides and Identification of a New Protein Disulfide Isomerase in Conus caracteristicus Using Integrated Transcriptomic and Proteomic Analysis.xlsx

, 2022
Current ConoServer database accumulates 8,134 conopeptides from 122 species of cone snail, which are pharmaceutically attractive marine resource. However, many more conopeptides remain to be discovered, and the enzymes involved in their synthesis and ...
Han Zhang (110653), Lei Wang (6656), Fahui Gong (12162821), Baoting Nong (8652468), Yinbin Qiu (11501506), Xinghua Pan (3663958)   +5 more
core   +1 more source

Conotoxins as Tools to Understand the Physiological Function of Voltage-Gated Calcium (CaV) Channels

Marine Drugs, 2017
Voltage-gated calcium (CaV) channels are widely expressed and are essential for the completion of multiple physiological processes. Close regulation of their activity by specific inhibitors and agonists become fundamental to understand their role in ...
David Ramírez, Wendy Gonzalez, Rafael A. Fissore, Ingrid Carvacho   +3 more
doaj   +1 more source

FDA's stamp of approval: Unveiling peptide breakthroughs in cardiovascular diseases, ACE, HIV, CNS, and beyond

Journal of Peptide Science, Volume 30, Issue 11, November 2024.
This review provides an overview of FDA‐approved peptides, particularly those targeting cardiovascular diseases, human immunodeficiency, and central nervous system diseases, and also addresses conditions such as osteoporosis, thrombocytopenia, Cushing's disease, and hypoglycemia.
Othman Al Musaimi
wiley   +1 more source

P-superfamily conopeptides [PDF]

, 2006
reportThe present invention is directed to P-superfamily conopeptides, to DNA encoding precursors of the P-superfamily conopeptides and to the precursor ...
Hooper, David; Garrett, James E.; Corpuz, Gloria P.; Cruz, Lourdes, J.; McIntosh, Michael J.; Jones, Robert M., Olivera, Baldomero M.   +1 more
core