Results 61 to 70 of about 1,314 (186)
International Journal of Peptides, Volume 2013, Issue 1, 2013., 2013 Conus venoms are rich sources of biologically active peptides that act specifically on ionic channels and metabotropic receptors present at the neuromuscular junction, efficiently paralyzing the prey. Each species of Conus may have 50 to 200 uncharacterized bioactive peptides with pharmacological interest.
Maria Cristina Vianna Braga +6 more
wiley +1 more source
Tyrosine-rich Conopeptides Affect Voltage-gated K+ Channels [PDF]
Journal of Biological Chemistry, 2008 Two venom peptides, CPY-Pl1 (EU000528) and CPY-Fe1 (EU000529), characterized from the vermivorous marine snails Conus planorbis and Conus ferrugineus, define a new class of conopeptides, the conopeptide Y (CPY) family. The peptides have no disulfide cross-links and are 30 amino acids long; the high content of tyrosine is unprecedented for any native ...
Imperial, Julita S. +7 more
openaire +5 more sources
Les canaux calciques dépendants du voltage au coeur de la douleur [PDF]
, 2006 Les canaux calciques dépendants du voltage représentent une des voies principales d’entrée du calcium dans la cellule nerveuse où ils participent activement à l’excitabilité cellulaire et aux processus moléculaires de la transmission synaptique. Ils ont,
De Waard, Michel, Weiss, Norbert
core +1 more source
A Benchmark Dataset Comprising Partition and Distribution Coefficients of Linear Peptides
Dataset Papers in Science, Volume 2013, Issue 1, 2013., 2013 Peptides have a dominant role in biology; yet the study of their physical properties is at best sporadic. Peptide quantitative structure‐activity relationship (QSAR) lags far behind the QSAR analysis of drug‐like organic small molecules. Traditionally, QSAR has focussed on experimentally determined partition coefficients as the main descriptor of ...
Matthew N. Davies +3 more
wiley +1 more source
Current status and future directions of botulinum neurotoxins for targeting pain processing. [PDF]
, 2015 Current evidence suggests that botulinum neurotoxins (BoNTs) A1 and B1, given locally into peripheral tissues such as skin, muscles, and joints, alter nociceptive processing otherwise initiated by inflammation or nerve injury in animal models and humans.
Pellett, Sabine +2 more
core +2 more sources
British Journal of Pharmacology, Volume 182, Issue 3, Page 564-580, February 2025.Abstract Background and Purpose Botulinum neurotoxin type A1 (BoNT/A) is one of the most potent neurotoxins known. At the same time, it is also one of the safest therapeutic agents used for the treatment of several human disorders and in aesthetic medicine.
Mickaël Machicoane +9 more
wiley +1 more source
[Retracted] A Showcase of Bench‐to‐Bedside Regenerative Medicine at the 2010 ASNTR
The Scientific World Journal, Volume 11, Issue 1, Page 1842-1864, 2011., 2011 Insight into the expanding themes of regenerative medicine is provided by the American Society for Neural Therapy and Repair′s annual meeting. The 17th meeting covered a wide range of neurodegenerative disorders, exploring methods to elucidate the currently unknown mechanisms behind the disorders, as well as possible treatments ranging from the use of ...
David J. Eve +3 more
wiley +1 more source
α-Conopeptides specifically expressed in the salivary gland of Conus pulicarius [PDF]
Toxicon, 2008 To date, studies conducted on cone snail venoms have attributed the origins of this complex mixture of neuroactive peptides entirely to gene expression by the secretory cells lining the lumen of the venom duct. However, specialized tissues such as the salivary glands also secrete their contents into the anterior gut and could potentially contribute ...
Jason S, Biggs +2 more
openaire +2 more sources
Conotoxins as Tools to Understand the Physiological Function of Voltage-Gated Calcium (CaV) Channels
Marine Drugs, 2017 Voltage-gated calcium (CaV) channels are widely expressed and are essential for the completion of multiple physiological processes. Close regulation of their activity by specific inhibitors and agonists become fundamental to understand their role in ...
David Ramírez +3 more
doaj +1 more source
Molecular Phylogeny, Classification and Evolution of Conopeptides [PDF]
, 2018 Conopeptides are toxins expressed in the venom duct of cone snails (Conoidea, Conus). These are mostly well-structured peptides and mini-proteins with high potency and selectivity for a broad range of cellular targets.
Favreau, P. +4 more
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