Venomics-Accelerated Cone Snail Venom Peptide Discovery. [PDF]
Int J Mol Sci, 2018 Cone snail venoms are considered a treasure trove of bioactive peptides. Despite over 800 species of cone snails being known, each producing over 1000 venom peptides, only about 150 unique venom peptides are structurally and functionally characterized ...
Himaya SWA, Lewis RJ.
europepmc +10 more sources
Stenotrophomonas-Like Bacteria Are Widespread Symbionts in Cone Snail Venom Ducts. [PDF]
Appl Environ Microbiol, 2017 ABSTRACT Cone snails are biomedically important sources of peptide drugs, but it is not known whether snail-associated bacteria affect venom chemistry. To begin to answer this question, we performed 16S rRNA gene amplicon sequencing of eight cone snail species, comparing their microbiomes with each other and with those from a ...
Torres JP +8 more
europepmc +8 more sources
Diversity and Evolutionary Analysis of Venom Insulin Derived from Cone Snails [PDF]
ToxinsCone snails possess a diverse array of novel peptide toxins, which selectively target ion channels and receptors in the nervous and cardiovascular systems. These numerous novel peptide toxins are a valuable resource for future marine drug development. In
Qiqi Guo +6 more
doaj +7 more sources
Profiling the Paralytic Effects and Lethality of Cone Snail Venom Toxins Using Nanofractionation Analytics with In Vivo Zebrafish Larvae Assays [PDF]
ToxinsThis study presents nanofractionation analytics coupled with in vivo profiling of zebrafish embryo paralysis and lethality in response to toxins in cone snail venoms.
Jeroen Kool +6 more
doaj +5 more sources
Fingerprint Analysis and Comparison of Activity Differences of Crude Venom from Five Species of Vermivorous Cone Snail in the South China Sea [PDF]
Marine DrugsThe South China Sea is rich in cone snail resources, known for producing conotoxins with diverse biological activities such as analgesic, anticancer, and insecticidal effects.
Shibo Sun +6 more
doaj +5 more sources
Venom Diversity and Evolution in the Most Divergent Cone Snail Genus Profundiconus [PDF]
Toxins, 2019 Profundiconus is the most divergent cone snail genus and its unique phylogenetic position, sister to the rest of the family Conidae, makes it a key taxon for examining venom evolution and diversity. Venom gland and foot transcriptomes of Profundiconus cf.
Giulia Fassio +8 more
doaj +9 more sources
Diversity of Conopeptides and Conoenzymes from the Venom Duct of the Marine Cone Snail Conus bayani as Determined from Transcriptomic and Proteomic Analyses [PDF]
Marine Drugs, 2021 Marine cone snails are predatory gastropods characterized by a well-developed venom apparatus and highly evolved hunting strategies that utilize toxins to paralyze prey and defend against predators.
Rajesh Rajaian Pushpabai +4 more
doaj +3 more sources
Cone snail species off the Brazilian coast and their venoms: a review and update [PDF]
Journal of Venomous Animals and Toxins including Tropical Diseases, 2023 The genus Conus includes over 900 species of marine invertebrates known as cone snails, whose venoms are among the most powerful described so far.
Helena B. Fiorotti +3 more
doaj +3 more sources
Cone snail venom-inspired somatostatin receptor 4 (SSTR<sub>4</sub>) agonists as new drug leads for peripheral pain. [PDF]
Sci RepPersistent pain affects one in five people worldwide, often with severely debilitating consequences. While current treatments can be effective for mild or acute pain, they are largely inadequate for managing moderate to severe chronic pain, underscoring ...
Bjørn-Yoshimoto WE +14 more
europepmc +4 more sources
Proteo-Transcriptomic Analysis of the Venom Gland of the Cone Snail <i>Cylinder canonicus</i> Reveals the Origin of the Predatory-Evoked Venom. [PDF]
Toxins (Basel)Cone snails are carnivorous marine predators that prey on mollusks, worms, or fish. They purposefully inject a highly diversified and peptide-rich venom, which can vary according to the predatory or defensive intended use.
Ratibou Z +8 more
europepmc +4 more sources