Results 1 to 10 of about 267,969 (148)

Fingerprint Analysis and Comparison of Activity Differences of Crude Venom from Five Species of Vermivorous Cone Snail in the South China Sea [PDF]

Marine Drugs
The South China Sea is rich in cone snail resources, known for producing conotoxins with diverse biological activities such as analgesic, anticancer, and insecticidal effects.
Bingmiao Gao, Shibo Sun
exaly   +5 more sources

Profiling the Paralytic Effects and Lethality of Cone Snail Venom Toxins Using Nanofractionation Analytics with In Vivo Zebrafish Larvae Assays [PDF]

Toxins
This study presents nanofractionation analytics coupled with in vivo profiling of zebrafish embryo paralysis and lethality in response to toxins in cone snail venoms.
Jeroen Kool, Arif Arrahman, Haifeng Xu, Jiaxing Liu, Richard J. Lewis, Christian Tudorache, Fernanda C. Cardoso   +6 more
doaj   +3 more sources

Comparative analysis of venom genes in the chromosome-level genomes of two closely related cone snails [PDF]

BMC Genomics
Background Venom cocktails of cone snails are characterized by their dynamic composition and the rapid evolution of toxin-encoding genes due to various selective pressures.
Ana Herráez-Pérez, Rafael Zardoya
doaj   +2 more sources

Conkazal-M1 from the MKAVA family of conotoxins: A dual-function protease inhibitor and neuroactive peptide. [PDF]

Protein Sci
Abstract Marine cone snails produce a diverse array of bioactive peptides, known as conotoxins, in their venom. Given their high target potency and specificity, conotoxins are attractive compounds for the development of precision research tools and pharmacological agents.
Hackney CM, Koch TL, Ryding NL, Rogalski A, Chase K, Giglio ML, Espino SS, Acyatan ZG, Watkins M, Olivera BM, Safavi-Hemami H, Teilum K, Ellgaard L.   +12 more
europepmc   +2 more sources

Total synthesis and structural characterization of a novel protein scaffold from the snail Biomphalaria glabrata. [PDF]

Protein Sci
Abstract Disulfide‐rich miniproteins constitute compact and highly stable scaffolds of growing interest for molecular and structural engineering. Schistosomins are ~80‐residue proteins conserved across gastropods that form a long‐standing orphan family whose structure and biological roles have remained unknown.
Melnyk O, Caby S, Vigouroux A, Demanche C, Desmet R, Sénéchal M, Snella B, Mougel A, Boidin-Wichlacz C, Parmentier A, Pasco U, Cantel S, Moréra S, Vicogne J.   +13 more
europepmc   +2 more sources

Cysteine pattern barcoding-based dataset filtration enhances the machine learning-assisted interpretation of Conus venom peptide therapeutics. [PDF]

PLoS ONE
Crude cone snail venom is a rich source of bioactive compounds with significant therapeutic potential. In this study, we conducted a comprehensive analysis of 5,985 cone snail peptides across 82 Conus species to identify unique cysteine (Cys) patterns ...
Rimsha Bibi, Noshaba Qasmi, Sajid Rashid
doaj   +2 more sources

Structural similarities reveal an expansive conotoxin family with a two-finger toxin fold. [PDF]

Protein Sci
Abstract Venomous animals have evolved a diverse repertoire of toxins with considerable pharmaceutical potential. The rapid evolution of peptide toxins, such as the conotoxins produced by venomous marine cone snails, often complicates efforts to infer their evolutionary relationships based solely on sequence information.
Khilji MS, Hackney CM, Koch TL, Hone AJ, Rogalski A, Watkins M, Tun J, McIntosh JM, Olivera B, Safavi-Hemami H, Teilum K, Ellgaard L.   +11 more
europepmc   +2 more sources

The Biological Role of Conoporins, Actinoporin-like Pore-Forming Toxins from Cone Snails [PDF]

Toxins
Cone snails are a large group of marine gastropods that produce a complex mixture of toxic compounds to hunt prey and defend against predators. The majority of the venom comprises small toxic peptides named conotoxins, which target membrane receptors. In
Matija Ruparčič, Gašper Šolinc, Simon Caserman, Juan Carlos Garcia Galindo, Manuel Jimenez Tenorio, Gregor Anderluh   +5 more
doaj   +2 more sources

Geographic Variation in Diet and Genetic Connectivity of Populations of the Widespread Predatory Cone Snail <i>Conus miliaris</i>. [PDF]

Ecol Evol
We examined patterns of dietary and genetic variation of a broadly distributed, Indo‐West Pacific cone snail at four sites in French Polynesia and compared them to populations at Guam, American Samoa, and Rapa Nui. Our results indicate that populations at French Polynesia possess broad and overlapping diets that are most similar to those of Rapa Nui ...
Duda TF, Vergara-Flórez DC.
europepmc   +2 more sources

A Conceptual Review of Naturally Occurring Toxins and Venoms as Peptide Blockers to Combat Chronic Low Back Pain. [PDF]

JOR Spine
This review explores the therapeutic potential of naturally occurring venom‐derived peptides, particularly from reptiles and insects, as novel calcium channel blockers for managing chronic low back pain caused by intervertebral disc degeneration.
Melrose J, Sima S, Chopra N, Diwan A, Gu Z.   +4 more
europepmc   +2 more sources