Fingerprint Analysis and Comparison of Activity Differences of Crude Venom from Five Species of Vermivorous Cone Snail in the South China Sea [PDF]
Marine DrugsThe South China Sea is rich in cone snail resources, known for producing conotoxins with diverse biological activities such as analgesic, anticancer, and insecticidal effects.
Yanling Liao, Jinxing Fu, Kailin Mao
exaly +4 more sources
Venomics-Accelerated Cone Snail Venom Peptide Discovery [PDF]
International Journal of Molecular Sciences, 2018 Cone snail venoms are considered a treasure trove of bioactive peptides. Despite over 800 species of cone snails being known, each producing over 1000 venom peptides, only about 150 unique venom peptides are structurally and functionally characterized.
S W A Himaya +2 more
exaly +8 more sources
Stenotrophomonas-Like Bacteria Are Widespread Symbionts in Cone Snail Venom Ducts [PDF]
Applied and Environmental Microbiology, 2017 ABSTRACT Cone snails are biomedically important sources of peptide drugs, but it is not known whether snail-associated bacteria affect venom chemistry. To begin to answer this question, we performed 16S rRNA gene amplicon sequencing of eight cone snail species, comparing their microbiomes with each other and with those from a ...
Joshua P Torres +2 more
exaly +5 more sources
Profiling the Paralytic Effects and Lethality of Cone Snail Venom Toxins Using Nanofractionation Analytics with In Vivo Zebrafish Larvae Assays [PDF]
ToxinsThis study presents nanofractionation analytics coupled with in vivo profiling of zebrafish embryo paralysis and lethality in response to toxins in cone snail venoms.
Jeroen Kool +6 more
doaj +2 more sources
Prey Shifts Drive Venom Evolution in Cone Snails [PDF]
Molecular Biology and EvolutionAbstract Venom systems are complex traits that have independently emerged multiple times in diverse plant and animal phyla. Within each venomous lineage there typically exists interspecific variation in venom composition where several factors have been proposed as drivers of variation, including phylogeny and diet.
Thomas Lund Koch +2 more
exaly +9 more sources
Comparative analysis of venom genes in the chromosome-level genomes of two closely related cone snails [PDF]
BMC GenomicsBackground Venom cocktails of cone snails are characterized by their dynamic composition and the rapid evolution of toxin-encoding genes due to various selective pressures.
Ana Herráez-Pérez, Rafael Zardoya
doaj +2 more sources
Non-Peptidic Small Molecule Components from Cone Snail Venoms [PDF]
Frontiers in Pharmacology, 2021 Venomous molluscs (Superfamily Conoidea) comprise a substantial fraction of tropical marine biodiversity (>15,000 species). Prior characterization of cone snail venoms established that bioactive venom components used to capture prey, defend against ...
Zhenjian Lin +14 more
doaj +5 more sources
Venomics Reveals Venom Complexity of the Piscivorous Cone Snail, Conus tulipa [PDF]
Marine Drugs, 2019 The piscivorous cone snail Conus tulipa has evolved a net-hunting strategy, akin to the deadly Conus geographus, and is considered the second most dangerous cone snail to humans. Here, we present the first venomics study of C.
Mriga Dutt +5 more
doaj +6 more sources
Cysteine pattern barcoding-based dataset filtration enhances the machine learning-assisted interpretation of Conus venom peptide therapeutics. [PDF]
PLoS ONECrude cone snail venom is a rich source of bioactive compounds with significant therapeutic potential. In this study, we conducted a comprehensive analysis of 5,985 cone snail peptides across 82 Conus species to identify unique cysteine (Cys) patterns ...
Rimsha Bibi, Noshaba Qasmi, Sajid Rashid
doaj +2 more sources
The Biological Role of Conoporins, Actinoporin-like Pore-Forming Toxins from Cone Snails [PDF]
ToxinsCone snails are a large group of marine gastropods that produce a complex mixture of toxic compounds to hunt prey and defend against predators. The majority of the venom comprises small toxic peptides named conotoxins, which target membrane receptors. In
Matija Ruparčič +5 more
doaj +2 more sources