Results 41 to 50 of about 5,046 (227)
Analysis of a cone snail's killer cocktail – The milked venom of Conus geographus [PDF]
Toxicon, 2012 "Snails can kill" is a statement that receives much disbelief. Yet the venom from Conus geographus, as delivered by a disposable hypodermic-like needle, has indeed killed many unsuspecting human victims. Our understanding of their milked venom the essence of these fatalities, is in itself non-existent.
Jon-Paul, Bingham +2 more
openaire +4 more sources
Proteomic analysis of the venom of Conus flavidus from Red Sea reveals potential pharmacological applications [PDF]
Journal of Genetic Engineering and BiotechnologyBackground: Venomous marine cone snails produce unique neurotoxins called conopeptides or conotoxins, which are valuable for research and drug discovery.
Mousa O. Germoush +9 more
doaj +2 more sources
In Silico Conotoxin Studies: Progress and Prospects [PDF]
MoleculesCone snails of the genus Conus have evolved to produce structurally distinct and functionally diverse venom peptides for defensive and predatory purposes.
Ruihan Li, Md. Mahadhi Hasan, Dan Wang
doaj +2 more sources
Targeted Sequencing of Venom Genes from Cone Snail Genomes Improves Understanding of Conotoxin Molecular Evolution [PDF]
Molecular biology and evolution, 2018 Mark A. Phuong, Gusti Ngurah Mahardika
openalex +2 more sources
Conkazal-M1 from the MKAVA family of conotoxins: A dual-function protease inhibitor and neuroactive peptide. [PDF]
Protein SciAbstract Marine cone snails produce a diverse array of bioactive peptides, known as conotoxins, in their venom. Given their high target potency and specificity, conotoxins are attractive compounds for the development of precision research tools and pharmacological agents.
Hackney CM +12 more
europepmc +2 more sources
Characterization of the venom of the vermivorous cone snail Conus fulgetrum [PDF]
Bioscience, Biotechnology, and Biochemistry, 2016 Abstract Over 200 components with molecular mass ranging mainly from 400 to 4000 Da were characterized from the venom of the vermivorous cone snail Conus fulgetrum that inhabit Egyptian Red Sea. One major component having a molecular mass of 2946 Da was purified by HPLC, and its primary structure was determined by a combination of Edman ...
Mohammed Abdel-Wahab +8 more
openalex +3 more sources
Hormone-like peptides in the venoms of marine cone snails [PDF]
General and Comparative Endocrinology, 2015 The venoms of cone snails (genus Conus) are remarkably complex, consisting of hundreds of typically short, disulfide-rich peptides termed conotoxins. These peptides have diverse pharmacological targets, with injection of venom eliciting a range of physiological responses, including sedation, paralysis and sensory overload.
Samuel D. Robinson +8 more
openalex +5 more sources
Cone snail genome sheds light on venom evolution
, 2021 <strong> This week in <em> GigaScience </em> we published the genome of the mediterranean cone snail, <em> Lautoconus ventricosus </em> . Cone snails produce a wide variety of powerful toxins and the new chromosome-scale genome assembly opens the door for detailed investigations of their diversity and evolution.
Hans Zauner
openalex +2 more sources
Iranian South Medical Journal, 2014 Background: Today use conotoxin as a neurotoxin and cytotoxin in medical science is obvious. These compounds are produced by venomous cone snails. Toxins produced by the venom apparatus of this snail and injected into the prey.
Ferial Monsef +2 more
doaj +1 more source
Structural similarities reveal an expansive conotoxin family with a two-finger toxin fold. [PDF]
Protein SciAbstract Venomous animals have evolved a diverse repertoire of toxins with considerable pharmaceutical potential. The rapid evolution of peptide toxins, such as the conotoxins produced by venomous marine cone snails, often complicates efforts to infer their evolutionary relationships based solely on sequence information.
Khilji MS +11 more
europepmc +2 more sources