Results 21 to 30 of about 1,336 (154)

Combined Proteotranscriptomic-Based Strategy to Discover Novel Antimicrobial Peptides from Cone Snails

Biomedicines, 2021
Despite their impressive diversity and already broad therapeutic applications, cone snail venoms have received less attention as a natural source in the investigation of antimicrobial peptides than other venomous animals such as scorpions, spiders, or ...
Anicet Ebou, Dominique Koua, Audrey Addablah, Solange Kakou-Ngazoa, Sébastien Dutertre   +4 more
doaj   +1 more source

Venomics Reveals a Non-Compartmentalised Venom Gland in the Early Diverged Vermivorous Conus distans

Toxins, 2022
The defensive use of cone snail venom is hypothesised to have first arisen in ancestral worm-hunting snails and later repurposed in a compartmentalised venom duct to facilitate the dietary shift to molluscivory and piscivory.
Jutty Rajan Prashanth, Sebastien Dutertre, Subash Kumar Rai, Richard J. Lewis   +3 more
doaj   +1 more source

A Combined Transcriptomics and Proteomics Approach Reveals the Differences in the Predatory and Defensive Venoms of the Molluscivorous Cone Snail Cylinder ammiralis (Caenogastropoda: Conidae)

Toxins, 2021
Venoms are complex mixtures of proteins that have evolved repeatedly in the animal kingdom. Cone snail venoms represent one of the best studied venom systems.
Samuel Abalde, Sébastien Dutertre, Rafael Zardoya   +2 more
doaj   +1 more source

Geographic Variation in Diet and Genetic Connectivity of Populations of the Widespread Predatory Cone Snail <i>Conus miliaris</i>. [PDF]

Ecol Evol
We examined patterns of dietary and genetic variation of a broadly distributed, Indo‐West Pacific cone snail at four sites in French Polynesia and compared them to populations at Guam, American Samoa, and Rapa Nui. Our results indicate that populations at French Polynesia possess broad and overlapping diets that are most similar to those of Rapa Nui ...
Duda TF, Vergara-Flórez DC.
europepmc   +2 more sources

Hormone-like peptides in the venoms of marine cone snails [PDF]

General and Comparative Endocrinology, 2017
The venoms of cone snails (genus Conus) are remarkably complex, consisting of hundreds of typically short, disulfide-rich peptides termed conotoxins. These peptides have diverse pharmacological targets, with injection of venom eliciting a range of physiological responses, including sedation, paralysis and sensory overload.
Robinson, Samuel D., Li, Qing, Bandyopadhyay, Pradip K., Gajewiak, Joanna, Yandell, Mark, Papenfuss, Anthony T., Purcell, Anthony W., Norton, Raymond S., Safavi-Hemami, Helena   +8 more
openaire   +4 more sources

A Conceptual Review of Naturally Occurring Toxins and Venoms as Peptide Blockers to Combat Chronic Low Back Pain. [PDF]

JOR Spine
This review explores the therapeutic potential of naturally occurring venom‐derived peptides, particularly from reptiles and insects, as novel calcium channel blockers for managing chronic low back pain caused by intervertebral disc degeneration.
Melrose J, Sima S, Chopra N, Diwan A, Gu Z.   +4 more
europepmc   +2 more sources

Dietary breadth is positively correlated with venom complexity in cone snails [PDF]

BMC Genomics, 2015
Abstract Although diet is believed to be a major factor underlying the evolution of venom, few comparative studies examine both venom composition and diet across a radiation of venomous species. Cone snails within the family, Conidae, comprise more than 700 species of carnivorous marine snails that capture their prey by using a cocktail
Phuong, Mark A, Mahardika, Gusti N, Alfaro, Michael E   +2 more
openaire   +4 more sources

Recruitment of Glycosyl Hydrolase Proteins in a Cone Snail Venomous Arsenal: Further Insights into Biomolecular Features of Conus Venoms

Marine Drugs, 2012
Cone snail venoms are considered an untapped reservoir of extremely diverse peptides, named conopeptides, displaying a wide array of pharmacological activities.
Philippe Favreau, Igor Križaj, Frédéric Ducancel, Reto Stöcklin, Florian Noguier, Sébastien Dutertre, Daniel Biass, David Piquemal, Yves Terrat, Adrijana Leonardi, Aude Violette   +10 more
doaj   +1 more source

Characterization of the venom of the vermivorous cone snail Conus fulgetrum [PDF]

Bioscience, Biotechnology, and Biochemistry, 2016
Abstract Over 200 components with molecular mass ranging mainly from 400 to 4000 Da were characterized from the venom of the vermivorous cone snail Conus fulgetrum that inhabit Egyptian Red Sea. One major component having a molecular mass of 2946 Da was purified by HPLC, and its primary structure was determined by a combination of Edman ...
Mohammed, Abdel-Wahab, Masahiro, Miyashita, Atsushi, Kitanaka, Hironori, Juichi, Moustafa, Sarhan, Maged, Fouda, Mohamed, Abdel-Rahman, Samy, Saber, Yoshiaki, Nakagawa   +8 more
openaire   +2 more sources

Efficient oxidative folding of conotoxins and the radiation of venomous cone snails [PDF]

Proceedings of the National Academy of Sciences, 2003
The 500 different species of venomous cone snails (genus Conus ) use small, highly structured peptides (conotoxins) for interacting with prey, predators, and competitors. These peptides are produced by translating mRNA from many genes belonging to only a few gene superfamilies.
Grzegorz, Bulaj, Olga, Buczek, Ian, Goodsell, Elsie C, Jimenez, Jessica, Kranski, Jacob S, Nielsen, James E, Garrett, Baldomero M, Olivera   +7 more
openaire   +2 more sources