Results 21 to 30 of about 267,969 (148)

In Silico Conotoxin Studies: Progress and Prospects [PDF]

Molecules
Cone snails of the genus Conus have evolved to produce structurally distinct and functionally diverse venom peptides for defensive and predatory purposes.
Ruihan Li, Md. Mahadhi Hasan, Dan Wang
doaj   +2 more sources

A structurally minimized yet fully active insulin based on cone-snail venom insulin principles. [PDF]

Nat Struct Mol Biol, 2020
Human insulin and its current therapeutic analogs all show propensity, albeit varyingly, to self-associate into dimers and hexamers, which delays their onset of action and makes blood glucose management difficult for people with diabetes.
Xiong X, Menting JG, Disotuar MM, Smith NA, Delaine CA, Ghabash G, Agrawal R, Wang X, He X, Fisher SJ, MacRaild CA, Norton RS, Gajewiak J, Forbes BE, Smith BJ, Safavi-Hemami H, Olivera B, Lawrence MC, Chou DH.   +18 more
europepmc   +2 more sources

Combined Proteotranscriptomic-Based Strategy to Discover Novel Antimicrobial Peptides from Cone Snails

Biomedicines, 2021
Despite their impressive diversity and already broad therapeutic applications, cone snail venoms have received less attention as a natural source in the investigation of antimicrobial peptides than other venomous animals such as scorpions, spiders, or ...
Anicet Ebou, Dominique Koua, Audrey Addablah, Solange Kakou-Ngazoa, Sébastien Dutertre   +4 more
doaj   +1 more source

Venomics Reveals a Non-Compartmentalised Venom Gland in the Early Diverged Vermivorous Conus distans

Toxins, 2022
The defensive use of cone snail venom is hypothesised to have first arisen in ancestral worm-hunting snails and later repurposed in a compartmentalised venom duct to facilitate the dietary shift to molluscivory and piscivory.
Jutty Rajan Prashanth, Sebastien Dutertre, Subash Kumar Rai, Richard J. Lewis   +3 more
doaj   +1 more source

A Combined Transcriptomics and Proteomics Approach Reveals the Differences in the Predatory and Defensive Venoms of the Molluscivorous Cone Snail Cylinder ammiralis (Caenogastropoda: Conidae)

Toxins, 2021
Venoms are complex mixtures of proteins that have evolved repeatedly in the animal kingdom. Cone snail venoms represent one of the best studied venom systems.
Samuel Abalde, Sébastien Dutertre, Rafael Zardoya   +2 more
doaj   +1 more source

Venom Apparatus Structure and Conutoxins Granules formation in Cone Snail (Conus coronatus) of Persian Gulf

Iranian South Medical Journal, 2014
Background: Today use conotoxin as a neurotoxin and cytotoxin in medical science is obvious. These compounds are produced by venomous cone snails. Toxins produced by the venom apparatus of this snail and injected into the prey.
Ferial Monsef, Saber Khodabandeh, Iraj Nabipour   +2 more
doaj   +1 more source

The mitochondrial genome of the venomous cone snail conus consors [PDF]

, 2012
Cone snails are venomous predatory marine neogastropods that belong to the species-rich superfamily of the Conoidea. So far, the mitochondrial genomes of two cone snail species (Conus textile and Conus borgesi) have been described, and these feed on ...
Ilka Wittig (112856), Juliana Heidler (112852), Silke Kauferstein, Dietrich Mebs, Reto Stöcklin, Kauferstein, Silke, Age Brauer, Alexander Kurz (10807), Baden-Tillson, Holly, Tim Stockwell, Age Brauer (112844), Maido Remm (5990), Brauer, Age, Tim Stockwell (112847), Juliana Heidler, Kurz, Alexander, Heidler, Juliana, Silke Kauferstein (112859), Mebs, Dietrich, Ilka Wittig, Dietrich Mebs (112862), Remm, Maido, Stöcklin, Reto, Maido Remm, Wittig, Ilka, Reto Stöcklin (112864), Er Kurz, Alexander Kurz, Holly Baden-Tillson, Stockwell, Tim, Holly Baden-Tillson (112849)   +30 more
core   +2 more sources

Venomous secretions from marine snails of the Terebridae family target acetylcholine receptors [PDF]

, 2013
Venoms from cone snails (Conidae) have been extensively studied during the last decades, but those from other members of the suborder Toxoglossa, such as of Terebridae and Turridae superfamilies attracted less interest so far. Here, we report the effects
Wunder, C., Peigneur, S., Silke Kauferstein, Melaun, Christian, Annette Nicke, Nicke, Annette, Dietrich Mebs, Christian Melaun, Peigneur, Steve, Kauferstein, S., Kauferstein, Silke, Wunder, Cora, Kendel, Y., Mebs, D., Kurz, A., Steve Peigneur, Tytgat, Jan, Melaun, C., Kendel, Yvonne, Kurz, Alexander, Mebs, Dietrich, Yvonne Kendel, Jan Tytgat, Cora Wunder, Alexander Kurz, Nicke, A., Tytgat, J.   +26 more
core   +1 more source

Cone snail species off the Brazilian coast and their venoms: a review and update

Journal of Venomous Animals and Toxins including Tropical Diseases, 2023
The genus Conus includes over 900 species of marine invertebrates known as cone snails, whose venoms are among the most powerful described so far.
Helena B. Fiorotti, Suely G. Figueiredo, Fabiana V. Campos, Daniel C. Pimenta   +3 more
doaj   +1 more source

Proteomic analysis of Red Sea Conus taeniatus venom reveals potential biological applications

Journal of Venomous Animals and Toxins including Tropical Diseases, 2021
Background: Diverse and unique bioactive neurotoxins known as conopeptides or conotoxins are produced by venomous marine cone snails. Currently, these small and stable molecules are of great importance as research tools and platforms for discovering new ...
Maged M. A. Fouda, Mohammed Abdel-Wahab, Amal Mohammadien, Mousa O. Germoush, Moustafa Sarhan   +4 more
doaj   +1 more source