A structurally minimized yet fully active insulin based on cone-snail venom insulin principles. [PDF]
Nat Struct Mol Biol, 2020 Human insulin and its current therapeutic analogs all show propensity, albeit varyingly, to self-associate into dimers and hexamers, which delays their onset of action and makes blood glucose management difficult for people with diabetes.
Xiong X +18 more
europepmc +3 more sources
A Combined Transcriptomics and Proteomics Approach Reveals the Differences in the Predatory and Defensive Venoms of the Molluscivorous Cone Snail Cylinder ammiralis (Caenogastropoda: Conidae) [PDF]
Toxins, 2021 Venoms are complex mixtures of proteins that have evolved repeatedly in the animal kingdom. Cone snail venoms represent one of the best studied venom systems.
Samuel Abalde +2 more
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Potential Ancestral Conoidean Toxins in the Venom Cocktail of the Carnivorous Snail Raphitoma purpurea (Montagu, 1803) (Neogastropoda: Raphitomidae) [PDF]
ToxinsVenomous marine gastropods of the superfamily Conoidea possess a rich arsenal of toxins, including neuroactive toxins. Venom adaptations might have played a fundamental role in the radiation of conoideans; nevertheless, there is still no knowledge about ...
Giacomo Chiappa +3 more
doaj +3 more sources
The mitochondrial genome of the venomous cone snail conus consors [PDF]
PLoS ONE, 2012 Cone snails are venomous predatory marine neogastropods that belong to the species-rich superfamily of the Conoidea. So far, the mitochondrial genomes of two cone snail species (Conus textile and Conus borgesi) have been described, and these feed on ...
Baden-Tillson, Holly +9 more
core +13 more sources
From DNA enzymes to cone snail venom: the work of Baldomero M. Olivera. [PDF]
J Biol Chem, 2012 Processivity of DNA Exonucleases (Thomas, K. R., and Olivera, B. M. (1978) J. Biol. Chem. 253, 424–429 )Neuronal Calcium Channel Inhibitors. Synthesis of ω-Conotoxin GVIA and Effects on 45Ca Uptake by Synaptosomes (Rivier, J., Galyean, R., Gray, W. R., Azimi-Zonooz, A., McIntosh, J. M., Cruz, L. J., and Olivera, B. M. (1987) J. Biol. Chem.
Mukhopadhya R.
europepmc +6 more sources
Cysteine‐free cone snail venom peptides: Classification of precursor proteins and identification of mature peptides [PDF]
Journal of Peptide Science, 2023 The cysteine‐free acyclic peptides present in marine cone snail venom have been much less investigated than their disulfide bonded counterparts. Precursor protein sequences derived from transcriptomic data, together with mass spectrometric fragmentation ...
Marimuthu Vijayasarathy +3 more
openalex +2 more sources
Comparative Venomics of C. flavidus and C. frigidus and Closely Related Vermivorous Cone Snails [PDF]
Marine Drugs, 2022 Cone snail venom biodiversity reflects dietary preference and predatory and defensive envenomation strategies across the ≈900 species of Conidae. To better understand the mechanisms of adaptive radiations in closely related species, we investigated the ...
S. W. A. Himaya +3 more
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Elucidation of the molecular envenomation strategy of the cone snail
BMC Genomics, 2012 Background The fish-hunting cone snail, Conus geographus, is the deadliest snail on earth. In the absence of medical intervention, 70% of human stinging cases are fatal.
Hu Hao +3 more
doaj +2 more sources
Venom variation during prey capture by the cone snail, Conus textile. [PDF]
PLoS ONE, 2014 Observations of the mollusc-hunting cone snail Conus textile during feeding reveal that prey are often stung multiple times in succession. While studies on the venom peptides injected by fish-hunting cone snails have become common, these approaches have ...
Cecilia A Prator +2 more
doaj +4 more sources
Cysteine pattern barcoding-based dataset filtration enhances the machine learning-assisted interpretation of Conus venom peptide therapeutics. [PDF]
PLoS ONECrude cone snail venom is a rich source of bioactive compounds with significant therapeutic potential. In this study, we conducted a comprehensive analysis of 5,985 cone snail peptides across 82 Conus species to identify unique cysteine (Cys) patterns ...
Rimsha Bibi, Noshaba Qasmi, Sajid Rashid
doaj +2 more sources