Venom variation during prey capture by the cone snail, Conus textile. [PDF]
PLoS ONE, 2014 Observations of the mollusc-hunting cone snail Conus textile during feeding reveal that prey are often stung multiple times in succession. While studies on the venom peptides injected by fish-hunting cone snails have become common, these approaches have ...
Cecilia A Prator +2 more
doaj +4 more sources
Predatory and Defensive Strategies in Cone Snails [PDF]
ToxinsCone snails are carnivorous marine animals that prey on fish (piscivorous), worms (vermivorous), or other mollusks (molluscivorous). They produce a complex venom mostly made of disulfide-rich conotoxins and conopeptides in a compartmentalized venom gland.
Zahrmina Ratibou +2 more
doaj +2 more sources
Venom Diversity and Evolution in the Most Divergent Cone Snail Genus Profundiconus [PDF]
Toxins, 2019 Profundiconus is the most divergent cone snail genus and its unique phylogenetic position, sister to the rest of the family Conidae, makes it a key taxon for examining venom evolution and diversity. Venom gland and foot transcriptomes of Profundiconus cf.
Giulia Fassio +8 more
doaj +6 more sources
Cone snail species off the Brazilian coast and their venoms: a review and update
Journal of Venomous Animals and Toxins including Tropical Diseases, 2023 The genus Conus includes over 900 species of marine invertebrates known as cone snails, whose venoms are among the most powerful described so far.
Helena B. Fiorotti +3 more
doaj +4 more sources
Diversity and Evolutionary Analysis of Venom Insulin Derived from Cone Snails
ToxinsCone snails possess a diverse array of novel peptide toxins, which selectively target ion channels and receptors in the nervous and cardiovascular systems. These numerous novel peptide toxins are a valuable resource for future marine drug development. In
Qiqi Guo +6 more
doaj +3 more sources
In Silico Conotoxin Studies: Progress and Prospects [PDF]
MoleculesCone snails of the genus Conus have evolved to produce structurally distinct and functionally diverse venom peptides for defensive and predatory purposes.
Ruihan Li, Md. Mahadhi Hasan, Dan Wang
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Conkazal-M1 from the MKAVA family of conotoxins: A dual-function protease inhibitor and neuroactive peptide. [PDF]
Protein SciAbstract Marine cone snails produce a diverse array of bioactive peptides, known as conotoxins, in their venom. Given their high target potency and specificity, conotoxins are attractive compounds for the development of precision research tools and pharmacological agents.
Hackney CM +12 more
europepmc +2 more sources
Structures and interactions of insulin-like peptides from cone snail venom. [PDF]
Proteins, 2022 AbstractThe venomous insulin‐like peptides released by certain cone snails stimulate hypoglycemic shock to immobilize fish and catch the prey. Compared to human insulin (hIns), the cone snail insulins (Con‐Ins) are typically monomeric and shorter in sequence, yet they exhibit moderate hIns‐like biological activity.
Gorai B, Vashisth H.
europepmc +4 more sources
Deep venomics reveals the mechanism for expanded peptide diversity in cone snail venom. [PDF]
Mol Cell Proteomics, 2013 Cone snails produce highly complex venom comprising mostly small biologically active peptides known as conotoxins or conopeptides. Early estimates that suggested 50-200 venom peptides are produced per species have been recently increased at least 10-fold using advanced mass spectrometry.
Dutertre S +5 more
europepmc +6 more sources
Structural similarities reveal an expansive conotoxin family with a two-finger toxin fold. [PDF]
Protein SciAbstract Venomous animals have evolved a diverse repertoire of toxins with considerable pharmaceutical potential. The rapid evolution of peptide toxins, such as the conotoxins produced by venomous marine cone snails, often complicates efforts to infer their evolutionary relationships based solely on sequence information.
Khilji MS +11 more
europepmc +2 more sources