Prey Shifts Drive Venom Evolution in Cone Snails. [PDF]
Mol Biol EvolVenom systems are complex traits that have independently emerged multiple times in diverse plant and animal phyla. Within each venomous lineage there typically exists interspecific variation in venom composition where several factors have been proposed ...
Koch TL +8 more
europepmc +9 more sources
Venom Insulins of Cone Snails Diversify Rapidly and Track Prey Taxa [PDF]
Molecular Biology and Evolution, 2016 A specialized insulin was recently found in the venom of a fish-hunting cone snail, Conus geographus. Here we show that many worm-hunting and snail-hunting cones also express venom insulins, and that this novel gene family has diversified explosively ...
Helena Safavi‐Hemami +8 more
core +9 more sources
Non-Peptidic Small Molecule Components from Cone Snail Venoms [PDF]
Frontiers in Pharmacology, 2021 Venomous molluscs (Superfamily Conoidea) comprise a substantial fraction of tropical marine biodiversity (>15,000 species). Prior characterization of cone snail venoms established that bioactive venom components used to capture prey, defend against ...
Zhenjian Lin +14 more
doaj +6 more sources
Structures and interactions of insulin-like peptides from cone snail venom. [PDF]
Proteins, 2022 The venomous insulin‐like peptides released by certain cone snails stimulate hypoglycemic shock to immobilize fish and catch the prey. Compared to human insulin (hIns), the cone snail insulins (Con‐Ins) are typically monomeric and shorter in sequence ...
Gorai B, Vashisth H.
europepmc +5 more sources
Conodipine-P1-3, the First Phospholipases A2 Characterized from Injected Cone Snail Venom. [PDF]
Mol Cell Proteomics, 2019 Cone snail venom is a wide source of active molecules that have potential pharmacological and biotechnological applications. Several proteins have been reported in the venom of cone snails. Here we describe the isolation and characterization of the sPLA2
Möller C +4 more
europepmc +4 more sources
Venomics Reveals Venom Complexity of the Piscivorous Cone Snail, Conus tulipa [PDF]
Marine Drugs, 2019 The piscivorous cone snail Conus tulipa has evolved a net-hunting strategy, akin to the deadly Conus geographus, and is considered the second most dangerous cone snail to humans. Here, we present the first venomics study of C.
Mriga Dutt +5 more
doaj +5 more sources
Transcriptomic-Proteomic Correlation in the Predation-Evoked Venom of the Cone Snail, Conus imperialis [PDF]
Marine Drugs, 2019 Individual variation in animal venom has been linked to geographical location, feeding habit, season, size, and gender. Uniquely, cone snails possess the remarkable ability to change venom composition in response to predatory or defensive stimuli.
Aihua Jin +6 more
semanticscholar +4 more sources
Deep venomics reveals the mechanism for expanded peptide diversity in cone snail venom. [PDF]
Mol Cell Proteomics, 2013 Cone snails produce highly complex venom comprising mostly small biologically active peptides known as conotoxins or conopeptides. Early estimates that suggested 50–200 venom peptides are produced per species have been recently increased at least 10-fold
Dutertre S +5 more
europepmc +5 more sources
Discovery by proteogenomics and characterization of an RF-amide neuropeptide from cone snail venom. [PDF]
J Proteomics, 2015 Robinson SD +8 more
europepmc +4 more sources
Structural characterisation of a cysteine-rich conotoxin, sigma(σ)S-GVIIIA, extracted from the defensive venom of the marine cone snail Conus geographus. [PDF]
Biochem JThe activity of the serotonin type 3 (5-HT3) receptor is associated with neurodegenerative, inflammatory and metabolic diseases, neuropsychiatric disorders and cancer.
Peck Y +8 more
europepmc +3 more sources