Results 71 to 80 of about 849 (177)

Data_Sheet_3_Discovery of 194 Unreported Conopeptides and Identification of a New Protein Disulfide Isomerase in Conus caracteristicus Using Integrated Transcriptomic and Proteomic Analysis.docx

, 2022
Current ConoServer database accumulates 8,134 conopeptides from 122 species of cone snail, which are pharmaceutically attractive marine resource. However, many more conopeptides remain to be discovered, and the enzymes involved in their synthesis and ...
Han Zhang (110653), Lei Wang (6656), Fahui Gong (12162821), Baoting Nong (8652468), Yinbin Qiu (11501506), Xinghua Pan (3663958)   +5 more
core   +1 more source

Transcriptomic Analysis of Marine Gastropod Hemifusus tuba Provides Novel Insights into Conotoxin Genes

Marine Drugs, 2019
The marine gastropod Hemifusus tuba is served as a luxury food in Asian countries and used in traditional Chinese medicine to treat lumbago and deafness. The lack of genomic data on H.
Ronghua Li, Michaël Bekaert, Luning Wu, Changkao Mu, Weiwei Song, Herve Migaud, Chunlin Wang   +6 more
doaj   +1 more source

Analysis of venom gland transcriptomes from two Tesseliconus species, Conus eburneus and Conus tessulatus, reveals inter- and intra-specific variations in conopeptide diversity and expression as well as putative novel gene superfamilies and disulfide-poor venom components

Frontiers in Marine Science
The Conus subgenus Tesseliconus, whose members are believed to be primarily worm-hunters, phylogenetically clusters closely with piscivorous groups relative to most other vermivorous subgenera. A previous study even documented the Tesseliconus species C.
Francis A. Tablizo, Francis A. Tablizo, Dan Jethro M. Masacupan, Dan Jethro M. Masacupan, Arturo O. Lluisma   +4 more
doaj   +1 more source

Conotoxin Patenting Trends in Academia and Industry

Marine Drugs, 2022
Sea snails of the genus Conus produce toxins that have been the subjects of numerous studies, projects, publications, and patents over the years. Since Conus toxins were discovered in the 1960s, their biological activity has been thought to have high ...
Noemi Sanchez-Campos, Johanna Bernaldez-Sarabia, Alexei F. Licea-Navarro   +2 more
doaj   +1 more source

The macrocycle inhibitor landscape of SLC‐transporter

Molecular Informatics, Volume 43, Issue 5, May 2024.
Abstract In the past years the interest in Solute Carrier Transporters (SLC) has increased due to their potential as drug targets. At the same time, macrocycles demonstrated promising activities as therapeutic agents. However, the overall macrocycle/SLC‐transporter interaction landscape has not been fully revealed yet.
Nejra Granulo, Sergey Sosnin, Daniela Digles, Gerhard F. Ecker   +3 more
wiley   +1 more source

Novel Conopeptides of Largely Unexplored Indo Pacific Conus sp.

Marine Drugs, 2016
Cone snails are predatory creatures using venom as a weapon for prey capture and defense. Since this venom is neurotoxic, the venom gland is considered as an enormous collection of pharmacologically interesting compounds having a broad spectrum of ...
Eline K. M. Lebbe, Maarten G. K. Ghequire, Steve Peigneur, Bea G. Mille, Prabha Devi, Samuthirapandian Ravichandran, Etienne Waelkens, Lisette D’Souza, René De Mot, Jan Tytgat   +9 more
doaj   +1 more source

Analogs of α‐conotoxin PnIC selectively inhibit α7β2‐ over α7‐only subtype nicotinic acetylcholine receptors via a novel allosteric mechanism

The FASEB Journal, Volume 38, Issue 1, 15 January 2024.
Analogs of α‐conotoxin PnIC selectively inhibit α7β2‐ over α7‐only subtype nicotinic acetylcholine receptors via a novel allosteric mechanism.Andrew A. George, Sabin J. John, Linda M. Lucero, J. Brek Eaton, Ekta Jaiswal, Sean B. Christensen, Joanna Gajewiak, Maren Watkins, Yiwei Cao, Baldomero M. Olivera, Wonpil Im, J.
Andrew A. George, Sabin J. John, Linda M. Lucero, J. Brek Eaton, Ekta Jaiswal, Sean B. Christensen, Joanna Gajewiak, Maren Watkins, Yiwei Cao, Baldomero M. Olivera, Wonpil Im, J. Michael McIntosh, Paul Whiteaker   +12 more
wiley   +1 more source

Cone Snails: A Big Store of Conotoxins for Novel Drug Discovery

Toxins, 2017
Marine drugs have developed rapidly in recent decades. Cone snails, a group of more than 700 species, have always been one of the focuses for new drug discovery.
Bingmiao Gao, Chao Peng, Jiaan Yang, Yunhai Yi, Junqing Zhang, Qiong Shi   +5 more
doaj   +1 more source

Venomics as a Drug Discovery Platform: Identifying Conopeptides with Pharmacological Activity [PDF]

, 2020
Cone snail venom is a mixture of disulfide-constrained peptides (conotoxins), hormone-like peptides, and proteins that have been ‘weaponized’ for predation and defense.
Grandal, Meghan Kathleen
core  

Characterisation of a Novel A-Superfamily Conotoxin

Biomedicines, 2020
Conopeptides belonging to the A-superfamily from the venomous molluscs, Conus, are typically α-conotoxins. The α-conotoxins are of interest as therapeutic leads and pharmacological tools due to their selectivity and potency at nicotinic acetylcholine ...
David T. Wilson, Paramjit S. Bansal, David A. Carter, Irina Vetter, Annette Nicke, Sébastien Dutertre, Norelle L. Daly   +6 more
doaj   +1 more source