Results 71 to 80 of about 1,314 (186)

Marine pharmacology in 2009-2011: marine compounds with antibacterial, antidiabetic, antifungal, anti-inflammatory, antiprotozoal, antituberculosis, and antiviral activities; affecting the immune and nervous systems, and other miscellaneous mechanisms of action. [PDF]

, 2013
The peer-reviewed marine pharmacology literature from 2009 to 2011 is presented in this review, following the format used in the 1998–2008 reviews of this series.
A. D. Rodriguez, A. M. S. Mayer, N. Fusetani, TAGLIALATELA SCAFATI, ORAZIO   +3 more
core   +2 more sources

Prey specificity of predatory venoms

Biological Reviews, Volume 99, Issue 6, Page 2253-2273, December 2024.
ABSTRACT Venom represents a key adaptation of many venomous predators, allowing them to immobilise prey quickly through chemical rather than physical warfare. Evolutionary arms races between prey and a predator are believed to be the main factor influencing the potency and composition of predatory venoms.
Ondřej Michálek, Glenn F. King, Stano Pekár   +2 more
wiley   +1 more source

Biodiversity, traditional medicine and public health: where do they meet? [PDF]

, 2007
Given the increased use of traditional medicines, possibilities that would ensure its successful integration into a public health framework should be explored.
Rômulo RN Alves, Ierecê ML Rosa, WHO World Health Organization, C Good, WM Gesler, Millennium Ecosystem Assessment, C Anyinam, RRN Alves, AJ McMichael, J Lebel, P Pushpangadan, E Chivian, CJ Cowden, KC Nicolaou, WP McGuire, BM Olivera, AB Malmberg, K Valentino, GP Miljanich, SS Bowersox, GP Jones, PK Anderson, PR Epstein, P Daszak, RS Ostfeld, JF Walsh, RS Ostfeld, SS Morse, RP Wenzel, AJ McMichael, P Reiter, D Bell, P Shanley, GC Daily, JB Calixto, J Kerharo, CA Anyinam, L Castello, S Gillingham, B Child, RS Pomeroy, K Michael, E Lev, E Yesilada, RRN Alves, MO Adeola, NR Farnsworth, NR Farnsworth, DD Soejarto, F Grifo, F Grifo, E Chivian, Center for Biodiversity and Conservation (CBC), E Chivian, NR Farnsworth, NR Farnsworth, MJ Balick, PA Cox, NR Farnsworth, PA Cox, WE Kunin, JGW Marques, World Resources Institute, NG Bisset, BK Carté, DJ Faulkner, S Kang, CM Correa, R Lettington, K Ten Kate, A Hamilton, GT Prance, W Balée, W Balée, LC Branch, MCM Amorozo, RA Voeks, JR Stepp, C Fowler, W Beinart, RA Voeks, OA Sodeinde, SR Silva, SBB – Sociedade brasileira de Botânica, SR Silva, PAGM De Smet, DS Fabricant, E Ernst, WHO (World Health Organization), J Still, PR Schnurrenberger, V Brown, SKH Lee, RP Labadie, G Bodeker, J Giordano   +95 more
core   +1 more source

FDA's stamp of approval: Unveiling peptide breakthroughs in cardiovascular diseases, ACE, HIV, CNS, and beyond

Journal of Peptide Science, Volume 30, Issue 11, November 2024.
This review provides an overview of FDA‐approved peptides, particularly those targeting cardiovascular diseases, human immunodeficiency, and central nervous system diseases, and also addresses conditions such as osteoporosis, thrombocytopenia, Cushing's disease, and hypoglycemia.
Othman Al Musaimi
wiley   +1 more source

Analysis of venom gland transcriptomes from two Tesseliconus species, Conus eburneus and Conus tessulatus, reveals inter- and intra-specific variations in conopeptide diversity and expression as well as putative novel gene superfamilies and disulfide-poor venom components

Frontiers in Marine Science
The Conus subgenus Tesseliconus, whose members are believed to be primarily worm-hunters, phylogenetically clusters closely with piscivorous groups relative to most other vermivorous subgenera. A previous study even documented the Tesseliconus species C.
Francis A. Tablizo, Francis A. Tablizo, Dan Jethro M. Masacupan, Dan Jethro M. Masacupan, Arturo O. Lluisma   +4 more
doaj   +1 more source

Novel conopeptides of largely unexplored Indo Pacific Conus sp. [PDF]

, 2016
Cone snails are predatory creatures using venom as a weapon for prey capture and defense. Since this venom is neurotoxic, the venom gland is considered as an enormous collection of pharmacologically interesting compounds having a broad spectrum of ...
D'Souza, L., De Mot, R., Devi, P., Ghequire, M.G.K., Lebbe, E.K.M., Mille, B.G., Peigneur, S., Ravichandran, S., Tytgat, J., Waelkens, E.   +9 more
core  

The mining of toxin-like polypeptides from EST database by single residue distribution analysis [PDF]

, 2011
Background Novel high throughput sequencing technologies require permanent development of bioinformatics data processing methods. Among them, rapid and reliable identification of encoded proteins plays a pivotal role.
Sergey Kozlov, Eugene Grishin
core   +1 more source

The macrocycle inhibitor landscape of SLC‐transporter

Molecular Informatics, Volume 43, Issue 5, May 2024.
Abstract In the past years the interest in Solute Carrier Transporters (SLC) has increased due to their potential as drug targets. At the same time, macrocycles demonstrated promising activities as therapeutic agents. However, the overall macrocycle/SLC‐transporter interaction landscape has not been fully revealed yet.
Nejra Granulo, Sergey Sosnin, Daniela Digles, Gerhard F. Ecker   +3 more
wiley   +1 more source

Current and Future Issues in the Development of Spinal Agents for the Management of Pain. [PDF]

, 2017
Targeting analgesic drugs for spinal delivery reflects the fact that while the conscious experience of pain is mediated supraspinally, input initiated by high intensity stimuli, tissue injury and/or nerve injury is encoded at the level of the spinal ...
Fisher, Casey J, Hockman, Tyler M, Wiese, Ashley J, Yaksh, Tony L   +3 more
core   +2 more sources

Cone Snails: A Big Store of Conotoxins for Novel Drug Discovery

Toxins, 2017
Marine drugs have developed rapidly in recent decades. Cone snails, a group of more than 700 species, have always been one of the focuses for new drug discovery.
Bingmiao Gao, Chao Peng, Jiaan Yang, Yunhai Yi, Junqing Zhang, Qiong Shi   +5 more
doaj   +1 more source