Molecular Pain, 2022 Development of chronic pain has been attributed to dysfunctional GABA signaling in the spinal cord. Direct pharmacological interventions on GABA signaling are usually not very efficient and often accompanied by side effects due to the widespread ...
Stanislava Jergova +2 more
doaj +1 more source
DNA barcoding of seven cone snail species from Red Sea coast of Egypt
Egyptian Journal of Aquatic Research, 2021 Cone snails are venomous predators comprising ~950 species widely distributed in different marine habitats. The production of bioactive molecules (known as conopeptides or conotoxins) marks the Conus as an utmost promising animal source for medicinal ...
Moustafa Sarhan +3 more
doaj +1 more source
A marine analgesic peptide, Contulakin-G, and neurotensin are distinct agonists for neurotensin receptors: uncovering structural determinants of desensitization properties [PDF]
, 2015 Neurotensin receptors have been studied as molecular targets for the treatment of pain, schizophrenia, addiction, or cancer. Neurotensin (NT) and Contulakin-G, a glycopeptide isolated from a predatory cone snail Conus geographus, share a sequence ...
Aleksandra eWalewska +10 more
core +2 more sources
Synthesis, Pharmacological and Structural Characterization of Novel Conopressins from Conus miliaris
Marine Drugs, 2020 Cone snails produce a fast-acting and often paralyzing venom, largely dominated by disulfide-rich conotoxins targeting ion channels. Although disulfide-poor conopeptides are usually minor components of cone snail venoms, their ability to target key ...
Julien Giribaldi +7 more
doaj +1 more source
Intraspecies variability and conopeptide profiling of the injected venom of Conus ermineus [PDF]
Peptides, 2011 The venom of cone snails (ssp. Conus), a genus of predatory mollusks, is a vast source of bioactive peptides. Conus venom expression is complex, and venom composition can vary considerably depending upon the method of extraction and the species of cone snail in question.
Jose A, Rivera-Ortiz +2 more
openaire +2 more sources
A Polychaete’s Powerful Punch: Venom Gland Transcriptomics of Glycera Reveals a Complex Cocktail of Toxin Homologs [PDF]
, 2014 © The Author(s) 2014. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/
Abdel-Rahman +120 more
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Bioactive Compounds Isolated from Neglected Predatory Marine Gastropods
Marine Drugs, 2018 A diverse range of predatory marine gastropods produce toxins, yet most of these molecules remain uncharacterized. Conus species have received the most attention from researchers, leading to several conopeptides reaching clinical trials. This review aims
Ashlin H. Turner +3 more
doaj +1 more source
A novel inhibitor of α9α10 nicotinic acetylcholine receptors from Conus vexillum delineates a new conotoxin superfamily. [PDF]
PLoS ONE, 2013 Conotoxins (CTxs) selectively target a range of ion channels and receptors, making them widely used tools for probing nervous system function. Conotoxins have been previously grouped into superfamilies according to signal sequence and into families based
Sulan Luo +8 more
doaj +1 more source
NMR structure of μ-conotoxin GIIIC : leucine 18 induces local repacking of the N-terminus resulting in reduced NaV channel potency [PDF]
, 2018 mu-Conotoxins are potent and highly specific peptide blockers of voltage-gated sodium channels. In this study, the solution structure of mu-conotoxin GIIIC was determined using 2D NMR spectroscopy and simulated annealing calculations.
Adams, David J +9 more
core +1 more source
Marine Drugs, 2013 Conotoxins are small peptides present in the venom of cone snails. The snail uses this venom to paralyze and capture prey. The constituent conopeptides display a high level of chemical diversity and are of particular interest for scientists as tools ...
Rolf Boelens +4 more
doaj +1 more source