Results 91 to 100 of about 849 (177)
Recombinant Expression and Characterization of α-Conotoxin LvIA in Escherichia coli
Marine Drugs, 2016 α-Conotoxin LvIA is derived from Conus lividus, native to Hainan, and is the most selective inhibitor of α3β2 nicotinic acetylcholine receptors (nAChRs) known to date.
Xiaopeng Zhu +6 more
doaj +1 more source
‘Messy’ Processing of χ-conotoxin MrIA Generates Homologues with Reduced hNET Potency
Marine Drugs, 2019 Integrated venomics techniques have shown that variable processing of conotoxins from Conus marmoreus resulted in a dramatic expansion in the number of expressed conotoxins. One conotoxin from C.
Rebekah Ziegman +5 more
doaj +1 more source
Mining Invertebrate Natural Products for Future Therapeutic Treasure
Natural Product Communications, 2011 This review focuses on biologically active entities from invertebrate sources, especially snails. The reader will encounter several categories of compounds from snails including glycosaminoglycans, peptides, proteins (glycoproteins), and enzymes which ...
Youmie Park
doaj +1 more source
Conopeptides promote itch through human itch receptor hMgprX1
, 2018 Members of Mas related G-protein coupled receptors (Mrgpr) are known to mediate itch. To date, several compounds have been shown to activate these receptors, including chloroquine, a common antimalarial drug, and peptides of the RF-amide family. However,
Liu, Qin +6 more
core +1 more source
Influence of Disulfide Connectivity on Structure and Bioactivity of α-Conotoxin TxIA
Molecules, 2014 Cone snails express a sophisticated arsenal of small bioactive peptides known as conopeptides or conotoxins (CTxs). Through evolutionary selection, these peptides have gained the ability to interact with a range of ion channels and receptors, such as ...
Yong Wu +5 more
doaj +1 more source
, 1994 High-threshold voltage-sensitive calcium channels of the N-type, L-type, and P-type have been distinguished in the mammalian CNS predominantly on the basis of their sensitivity to selective antagonists.
Ramachandran, J. +2 more
core +1 more source
, 2015 The venom of each species of Conus contains different kinds of pharmacologically active peptides which are mostly unique to that species. Collectively, the similar to 500-700 species of Conus produce a large number of these peptides, perhaps exceeding ...
Barghi, N. ; https://orcid.org/ +3 more
core +1 more source
Journal of Marine Science and EngineeringConus venoms are both highly powerful and complex, exhibiting a remarkably intriguing molecular variability. The biologic reasons behind such astonishing molecular diversity are yet to be fully understood.
José Morim +3 more
doaj +1 more source
, 2016 αD-Conotoxins are peptide inhibitors of nicotinic acetylcholine receptors (nAChRs) first described from Conus vexillum (αD-VxXIIA−C and renamed here to αD-VxXXA, αD-VxXXB, and αD-VxXXC).
Richard J. Lewis (30801) +3 more
core +1 more source
Limited efficacy of α-conopeptides, Vc1.1 and RglA, to inhibit sensory neuron Cav current
, 2015 Chronic pain is very difficult to treat. Thus, novel analgesics are a critical area of research. Strong preclinical evidence supports the analgesic effects of α-conopeptides, Vc1.1 and RgIA, which block α9α10 nicotinic acetylcholine receptors (nAChRs ...
McIntosh, J. Michael +3 more
core +1 more source