Results 101 to 110 of about 849 (177)

Toxinology of Marine Venomous Snails

Iranian South Medical Journal, 2021
A surprisingly large number of sea snail species are venomous. Cone snail venoms are produced in a lengthy tubular duct from a complex venom gland and form a cocktail of many toxins, particularly conotoxins which have high potency and specificity for ...
Gholam Hossein Mohebbi, Iraj Nabipour
doaj  

Novel alpha D-conopeptides and their precursors identified by cDNA cloning define the D-conotoxin superfamily

, 2009
alpha D-Conotoxins are peptide inhibitors of nicotinic acetylcholine receptors (nAChRs) first described from Conus vexillum (alpha D-VxXIIA-C and renamed here to alpha D-VxXXA, alpha D-VxXXB, and alpha D-VxXXC).
Lawrence, Nicole, Lewis, Richard J., Loughnan, Marion L., Lawrence, N., Nicke, A., Lewis, R., Loughnan, M., Nicke, Annette   +7 more
core   +1 more source

Conus venom peptide pharmacology

, 2012
Conopeptides are a diverse group of recently evolved venom peptides used for prey capture and/or defense. Each species of cone snails produces in excess of 1000 conopeptides, with those pharmacologically characterized (similar to 0.1%) targeting a ...
Lewis, Richard J., Christie, MacDonald J., Lewis, Richard,, Christie, Macdonald,, Dutertre, Sebastien, Vetter, Irina   +5 more
core   +1 more source

Comparison of the venom peptides and their expression in closely related Conus species: insights into adaptive post-speciation evolution of Conus Exogenomes

, 2015
Genes that encode products with exogenous targets, which comprise an organism's "exogenome," typically exhibit high rates of evolution. The genes encoding the venom peptides (conotoxins or conopeptides) in Conus sensu lato exemplify this class of genes ...
Barghi, N. ; https://orcid.org/, Concepcion, G., Olivera, B., Lluisma, A.   +3 more
core   +1 more source

Novel conopeptides of the I-superfamily occur in several clades of cone snails [PDF]

, 2004
The I-superfamily of conotoxins represents a new class of peptides in the venom of some Conus species. These toxins are characterized by four disulfide bridges and inhibit or modify ion channels of nerve cells.
Kauferstein, S., Huys, I., Kuch, U., Mebs, D., Tytgat, J., Melaun, C.   +5 more
core  

Systematic dissection of genomic features determining the vast diversity of conotoxins. [PDF]

BMC Genomics, 2023
Zheng JW, Lu Y, Yang YF, Huang D, Li DW, Wang X, Gao Y, Yang WD, Guan Y, Li HY.   +9 more
europepmc   +1 more source

Analgesic conopeptides targeting G protein-coupled receptors reduce excitability of sensory neurons

, 2017
Conotoxins (conopeptides) are a diverse group of peptides isolated from the venom of marine cone snails. Conus peptides modulate pain by interacting with voltage-gated ion channels and G protein-coupled receptors (GPCRs).
David Adams (19587271), Mahsa Sadeghi (20119410), Jeffrey McArthur (20120958), Rocio Finol Urdaneta (19586584)   +3 more
core   +1 more source

Principal Component and Structural Element Analysis Provide Insights into the Evolutionary Divergence of Conotoxins. [PDF]

Biology (Basel), 2022
Kikuchi AKV, Tayo LL.
europepmc   +1 more source

Effects of diet manipulation on conopeptide profiles in fish-eating conus striatus [PDF]

, 2014
There are approximately 500 different species of cone snails (Conus). Each armed with a unique venom profile used to immobilize prey and to defend against predators.
Andrews, Elizabeth Ann
core  

Isolation and characterization of five novel disulfide-poor conopeptides from Conus marmoreus venom. [PDF]

J Venom Anim Toxins Incl Trop Dis, 2022
Fu Y, Zhang Y, Ju S, Ma B, Huang W, Luo S.   +5 more
europepmc   +1 more source