Results 81 to 90 of about 849 (177)
Allosteric α1-Adrenoreceptor Antagonism by the Conopeptide ρ-TIA [PDF]
Journal of Biological Chemistry, 2003 A peptide contained in the venom of the predatory marine snail Conus tulipa, rho-TIA, has previously been shown to possess alpha1-adrenoreceptor antagonist activity. Here, we further characterize its pharmacological activity as well as its structure-activity relationships.
Sharpe, Iain A. +11 more
openaire +5 more sources
Synthesis, Pharmacological and Structural Characterization of Novel Conopressins from Conus miliaris
Marine Drugs, 2020 Cone snails produce a fast-acting and often paralyzing venom, largely dominated by disulfide-rich conotoxins targeting ion channels. Although disulfide-poor conopeptides are usually minor components of cone snail venoms, their ability to target key ...
Julien Giribaldi +7 more
doaj +1 more source
Molecular Pain, 2022 Development of chronic pain has been attributed to dysfunctional GABA signaling in the spinal cord. Direct pharmacological interventions on GABA signaling are usually not very efficient and often accompanied by side effects due to the widespread ...
Stanislava Jergova +2 more
doaj +1 more source
Overexpression, purification, and pharmacological activity of a biosynthetically derived conopeptide [PDF]
Biochemical and Biophysical Research Communications, 2005 A high yielding fusion protein system based on the protein cytochrome b(5) has been used for the production of novel 13-residue acyclic conopeptide. This peptide, Mo1659, can be liberated from the carrier protein using CNBr cleavage and subsequent purification using RP-HPLC methods. The yield of isotopically enriched peptides is high, ranging from 3 to
Kumar, Ganesan Senthil +3 more
openaire +3 more sources
Bioactive Compounds Isolated from Neglected Predatory Marine Gastropods
Marine Drugs, 2018 A diverse range of predatory marine gastropods produce toxins, yet most of these molecules remain uncharacterized. Conus species have received the most attention from researchers, leading to several conopeptides reaching clinical trials. This review aims
Ashlin H. Turner +3 more
doaj +1 more source
Marine Drugs, 2013 Conotoxins are small peptides present in the venom of cone snails. The snail uses this venom to paralyze and capture prey. The constituent conopeptides display a high level of chemical diversity and are of particular interest for scientists as tools ...
Rolf Boelens +4 more
doaj +1 more source
A novel inhibitor of α9α10 nicotinic acetylcholine receptors from Conus vexillum delineates a new conotoxin superfamily. [PDF]
PLoS ONE, 2013 Conotoxins (CTxs) selectively target a range of ion channels and receptors, making them widely used tools for probing nervous system function. Conotoxins have been previously grouped into superfamilies according to signal sequence and into families based
Sulan Luo +8 more
doaj +1 more source
Marine Drugs, 2014 A novel conotoxin (conopeptide) was biochemically characterized from the crude venom of the molluscivorous marine snail, Conus bandanus (Hwass in Bruguière, 1792), collected in the south-central coast of Vietnam.
Bao Nguyen +7 more
doaj +1 more source
Toxins 'R' Us : more pharmacological tools from nature's superstore
, 2002 Conus venoms from marine cone snails continue to provide novel bioactive components. Two new classes of conopeptide specifically block alpha(1)-adrenoceptors (rho-conopeptide) and noradrenaline transporters (chi-conopeptides).
Alan L Harvey, Harvey, Alan L
core +4 more sources
, 2020 This thesis describes the structure determination of peptides found in marine cone snails’ venom at atomic resolution and their biological activity. Chapter 1 gives a brief introduction to the cone snails, conopeptides, and basic NMR to determine the ...
Madhan Kumar, M
core