Results 81 to 90 of about 1,314 (186)
High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain [PDF]
, 2007 Little is known about the molecular basis of somatosensory mechanotransduction in mammals. We screened a library of peptide toxins for effects on mechanically activated currents in cultured dorsal root ganglion neurons.
Abrahamsen, B +11 more
core
Analgesic alpha-Conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABA-B receptor activation [PDF]
, 2008 alpha-Conotoxins Vc1.1 and Rg1A are peptides from the venom of marine Conus snails that are currently in development as a treatment for neuropathic pain. Here we report that the alpha 9 alpha 10 nicotinic acetylcholine receptor-selective conotoxins Vc1.1
Adams, David J. +5 more
core +2 more sources
The FASEB Journal, Volume 38, Issue 1, 15 January 2024.Analogs of α‐conotoxin PnIC selectively inhibit α7β2‐ over α7‐only subtype nicotinic acetylcholine receptors via a novel allosteric mechanism.Andrew A. George, Sabin J. John, Linda M. Lucero, J. Brek Eaton, Ekta Jaiswal, Sean B. Christensen, Joanna Gajewiak, Maren Watkins, Yiwei Cao, Baldomero M. Olivera, Wonpil Im, J.
Andrew A. George +12 more
wiley +1 more source
Conopeptides promote itch through human itch receptor hMgprX1 [PDF]
Toxicon, 2018 Members of Mas related G-protein coupled receptors (Mrgpr) are known to mediate itch. To date, several compounds have been shown to activate these receptors, including chloroquine, a common antimalarial drug, and peptides of the RF-amide family. However, specific ligands for these receptors are still lacking and there is a need for novel compounds that
Espino, Samuel S. +6 more
openaire +4 more sources
Characterisation of a Novel A-Superfamily Conotoxin
Biomedicines, 2020 Conopeptides belonging to the A-superfamily from the venomous molluscs, Conus, are typically α-conotoxins. The α-conotoxins are of interest as therapeutic leads and pharmacological tools due to their selectivity and potency at nicotinic acetylcholine ...
David T. Wilson +6 more
doaj +1 more source
Florida marine biotechnology: research, development and training capabilities to advance science and commerce [PDF]
, 2001 The level of activity and interest in “marine biotechnology” among Florida university faculty and allied laboratory scientists is reported in this document.
Seaman, William +1 more
core
Calcium channel modulation as a target in chronic pain control [PDF]
, 2017 Neuropathic pain remains poorly treated for large numbers of patients and little progress has been made in developing novel classes of analgesics. To redress this issue, ziconotide (PrialtTM ) was developed and approved as a first in class synthetic ...
Dickenson, AH +2 more
core +1 more source
Frontiers in Pharmacology, 2019 Venomous marine snails of the genus Conus employ small peptides to capture prey, mainly osteichthyes, mollusks, and worms. A subset of these peptides known as α-conotoxins, are antagonists of nicotinic acetylcholine receptors (nAChRs).
Veronika Grau +5 more
doaj +1 more source
DESM: portal for microbial knowledge exploration systems [PDF]
, 2015 Microorganisms produce an enormous variety of chemical compounds. It is of general interest for mi-crobiology and biotechnology researchers to have means to explore information about molecular and genetic basis of functioning of different microor-ganisms
Adil Salhi +22 more
core +1 more source
A vasopressin/oxytocin-related conopeptide with γ-carboxyglutamate at position 8 [PDF]
Biochemical Journal, 2007 Vasopressins and oxytocins are homologous, ubiquitous and multifunctional peptides present in animals. Conopressins are vasopressin/oxytocin-related peptides that have been found in the venom of cone snails, a genus of marine predatory molluscs that envenom their prey with a complex mixture of neuroactive peptides.
Carolina, Möller, Frank, Marí
openaire +2 more sources