Alpha9 nicotinic acetylcholine receptors and the treatment of pain [PDF]
, 2009 Chronic pain is a vexing worldwide problem that causes substantial disability and consumes significant medical resources. Although there are numerous analgesic medications, these work through a small set of molecular mechanisms.
Absalom, Nathan +4 more
core +1 more source
Bioactive Marine Drugs and Marine Biomaterials for Brain Diseases [PDF]
, 2014 Marine invertebrates produce a plethora of bioactive compounds, which serve as inspiration for marine biotechnology, particularly in drug discovery programs and biomaterials development.
Andrade, Paula B. +3 more
core +2 more sources
Allosteric α1-Adrenoreceptor Antagonism by the Conopeptide ρ-TIA [PDF]
Journal of Biological Chemistry, 2003 A peptide contained in the venom of the predatory marine snail Conus tulipa, rho-TIA, has previously been shown to possess alpha1-adrenoreceptor antagonist activity. Here, we further characterize its pharmacological activity as well as its structure-activity relationships.
Sharpe, Iain A. +11 more
openaire +4 more sources
Stabilization of α-conotoxin AuIB: Influences of disulfide connectivity and backbone cyclization [PDF]
, 2011 alpha-Conotoxins are peptides isolated from the venom ducts of cone snails that target nicotinic acetylcholine receptors (nAChRs). They are valuable pharmacological tools and have potential applications for treating a range of conditions in humans ...
Anton A. Grishin +10 more
core +1 more source
Marine Drugs, 2010 Neurotoxin receptor site 1, in the outer vestibule of the conducting pore of voltage-gated sodium channels (VGSCs), was first functionally defined by its ability to bind the guanidinium-containing agents, tetrodotoxin (TTX) and saxitoxin (STX ...
Baldomero M. Olivera +3 more
doaj +1 more source
Calcium channels controlling acetylcholine release from preganglionic nerve terminals in rat autonomic ganglia [PDF]
, 1999 Little is known about the nature of the calcium channels controlling neurotransmitter release from preganglionic parasympathetic nerve fibres. In the present study, the effects of selective calcium channel antagonists and amiloride were investigated on ...
A.B Smith +33 more
core +1 more source
The Evolution of Fangs, Venom, and Mimicry Systems in Blenny Fishes [PDF]
, 2017 Venom systems have evolved on multiple occasions across the animal kingdom, and they can act as key adaptations to protect animals from predators. Consequently, venomous animals serve as models for a rich source of mimicry types, as non-venomous ...
Amanda Nouwens +23 more
core +6 more sources
Overexpression, purification, and pharmacological activity of a biosynthetically derived conopeptide [PDF]
Biochemical and Biophysical Research Communications, 2005 A high yielding fusion protein system based on the protein cytochrome b(5) has been used for the production of novel 13-residue acyclic conopeptide. This peptide, Mo1659, can be liberated from the carrier protein using CNBr cleavage and subsequent purification using RP-HPLC methods. The yield of isotopically enriched peptides is high, ranging from 3 to
Kumar, Ganesan Senthil +3 more
openaire +3 more sources
Evolution: Fangtastic Venoms Underpin Parasitic Mimicry [PDF]
, 2017 Venomous teeth are rare in fishes, which typically utilise spines for defence. A new study reveals the evolutionary origins of fangs and venom in the Nemophini blennies and shows that, in contrast to snakes and lizards, the fangs pre-date the ...
Taylor, Martin I.
core +1 more source
Inventory and Distribution of Mollusc in Coral Reef of Bacan Island Waters, North Maluku Province [PDF]
, 2017 Bacan Island waters of North Maluku Province consisted of three main tropical ecosystems, namely mangrove, seagrass, and coral reef with the highest marine biodiversity.
Cappenberg, H. A. (Hendrik)
core +3 more sources