Results 51 to 60 of about 849 (177)

Data_Sheet_3_Identification of Novel Conopeptides and Distinct Gene Superfamilies in the Marine Cone Snail Conus quercinus.xlsx

, 2021
Conopeptides from the marine cone snails are a mixture of cysteine-rich active peptides, representing a unique and fertile resource for neuroscience research and drug discovery.
Han Zhang (110653), Lei Wang (6656), Zhiwei Lian (11501509), Yinbin Qiu (11501506), Zhanying Dong (11555315), Xuedong Wu (1471993), Xinghua Pan (3663958), Xiang Yang (223219)   +7 more
core   +1 more source

Engineered biosynthesis of cyclotides

New Zealand Journal of Botany, Volume 58, Issue 4, Page 358-377, December 2020., 2020
ABSTRACT A system based on cyanobacterial split inteins, SICLOPPs (Split Intein Circular Ligation of Proteins and Peptides), has been used to synthesise a small natively cyclic plant protein, kalata B1, and cyclised versions of the natively linear therapeutic peptides ziconotide and leconotide.
Thomas N. G. Handley, Hyon‐Xhi Tan, Malcolm T. Rutledge, Hans Henning Brewitz, Joel D. A. Tyndall, Torsten Kleffmann, Margi I. Butler, Russell T. M. Poulter, Sigurd M. Wilbanks   +8 more
wiley   +1 more source

Data_Sheet_1_Identification of Novel Conopeptides and Distinct Gene Superfamilies in the Marine Cone Snail Conus quercinus.docx

, 2021
Conopeptides from the marine cone snails are a mixture of cysteine-rich active peptides, representing a unique and fertile resource for neuroscience research and drug discovery.
Han Zhang (110653), Lei Wang (6656), Zhiwei Lian (11501509), Yinbin Qiu (11501506), Zhanying Dong (11555315), Xuedong Wu (1471993), Xinghua Pan (3663958), Xiang Yang (223219)   +7 more
core   +1 more source

The Tetrodotoxin Receptor of Voltage-Gated Sodium Channels—Perspectives from Interactions with μ-Conotoxins

Marine Drugs, 2010
Neurotoxin receptor site 1, in the outer vestibule of the conducting pore of voltage-gated sodium channels (VGSCs), was first functionally defined by its ability to bind the guanidinium-containing agents, tetrodotoxin (TTX) and saxitoxin (STX ...
Baldomero M. Olivera, Michael F. Sheets, Robert J. French, Doju Yoshikami   +3 more
doaj   +1 more source

Data_Sheet_2_Discovery of 194 Unreported Conopeptides and Identification of a New Protein Disulfide Isomerase in Conus caracteristicus Using Integrated Transcriptomic and Proteomic Analysis.docx

, 2022
Current ConoServer database accumulates 8,134 conopeptides from 122 species of cone snail, which are pharmaceutically attractive marine resource. However, many more conopeptides remain to be discovered, and the enzymes involved in their synthesis and ...
Han Zhang (110653), Lei Wang (6656), Fahui Gong (12162821), Baoting Nong (8652468), Yinbin Qiu (11501506), Xinghua Pan (3663958)   +5 more
core   +1 more source

Venomous secretions from marine snails of the Terebridae family target acetylcholine receptors [PDF]

, 2013
Venoms from cone snails (Conidae) have been extensively studied during the last decades, but those from other members of the suborder Toxoglossa, such as of Terebridae and Turridae superfamilies attracted less interest so far. Here, we report the effects
Wunder, C., Peigneur, S., Silke Kauferstein, Melaun, Christian, Annette Nicke, Nicke, Annette, Dietrich Mebs, Christian Melaun, Peigneur, Steve, Kauferstein, S., Kauferstein, Silke, Wunder, Cora, Kendel, Y., Mebs, D., Kurz, A., Steve Peigneur, Tytgat, Jan, Melaun, C., Kendel, Yvonne, Kurz, Alexander, Mebs, Dietrich, Yvonne Kendel, Jan Tytgat, Cora Wunder, Alexander Kurz, Nicke, A., Tytgat, J.   +26 more
core   +1 more source

α‐RgIB: A Novel Antagonist Peptide of Neuronal Acetylcholine Receptor Isolated from Conus regius Venom

International Journal of Peptides, Volume 2013, Issue 1, 2013., 2013
Conus venoms are rich sources of biologically active peptides that act specifically on ionic channels and metabotropic receptors present at the neuromuscular junction, efficiently paralyzing the prey. Each species of Conus may have 50 to 200 uncharacterized bioactive peptides with pharmacological interest.
Maria Cristina Vianna Braga, Arthur Andrade Nery, Henning Ulrich, Katsuhiro Konno, Juliana Mozer Sciani, Daniel Carvalho Pimenta, Ayman El-Faham   +6 more
wiley   +1 more source

Table_1_Discovery of 194 Unreported Conopeptides and Identification of a New Protein Disulfide Isomerase in Conus caracteristicus Using Integrated Transcriptomic and Proteomic Analysis.xlsx

, 2022
Current ConoServer database accumulates 8,134 conopeptides from 122 species of cone snail, which are pharmaceutically attractive marine resource. However, many more conopeptides remain to be discovered, and the enzymes involved in their synthesis and ...
Han Zhang (110653), Lei Wang (6656), Fahui Gong (12162821), Baoting Nong (8652468), Yinbin Qiu (11501506), Xinghua Pan (3663958)   +5 more
core   +1 more source

Cupryphans, metal‐binding, redox‐active, redesigned conopeptides [PDF]

Protein Science, 2009
AbstractContryphans are bioactive peptides, isolated from the venom of marine snails of the genus Conus, which are characterized by the short length of the polypeptide chain and the high degree of unusual post‐translational modifications. The cyclization of the polypeptide chain through a single disulphide bond, the presence of two conserved Pro ...
BARBA, MARCO, A. P. SOBOLEV, C. ROMEO, SCHININA', Maria Eugenia, D. PIETRAFORTE, MANNINA, LUISA, G. MUSCI, F. POLTICELLI   +7 more
openaire   +6 more sources

A Benchmark Dataset Comprising Partition and Distribution Coefficients of Linear Peptides

Dataset Papers in Science, Volume 2013, Issue 1, 2013., 2013
Peptides have a dominant role in biology; yet the study of their physical properties is at best sporadic. Peptide quantitative structure‐activity relationship (QSAR) lags far behind the QSAR analysis of drug‐like organic small molecules. Traditionally, QSAR has focussed on experimentally determined partition coefficients as the main descriptor of ...
Matthew N. Davies, Darren R. Flower, Liam McGuffin, Luis Alberto Ponce Soto   +3 more
wiley   +1 more source