The ATP-mediated cytokine release by macrophages is down-modulated by unconventional α9* nicotinic acetylcholine receptors [PDF]
Frontiers in ImmunologyObjectiveThe clinical interest in mechanisms controlling the biosynthesis and release of the pro-inflammatory cytokine interleukin (IL)-1β is outstanding, as IL-1β is associated with life-threatening inflammatory diseases including hyperinflammation ...
Philipp M. K. Wolf +20 more
doaj +2 more sources
Biomedical Potential of the Neglected Molluscivorous and Vermivorous Conus Species [PDF]
Marine Drugs, 2022 Within the Conidae family, the piscivorous Conus species have been a hotspot target for drug discovery. Here, we assess the relevance of Conus and their other feeding habits, and thus under distinctive evolutionary constraints, to highlight the potential
Yihe Zhao, Agostinho Antunes
doaj +2 more sources
Diversity of Conopeptides and Conoenzymes from the Venom Duct of the Marine Cone Snail Conus bayani as Determined from Transcriptomic and Proteomic Analyses [PDF]
Marine Drugs, 2021 Marine cone snails are predatory gastropods characterized by a well-developed venom apparatus and highly evolved hunting strategies that utilize toxins to paralyze prey and defend against predators.
Rajesh Rajaian Pushpabai +4 more
doaj +2 more sources
Anti-Ovarian Cancer Conotoxins Identified from Conus Venom [PDF]
Molecules, 2022 Conotoxins constitute a treasury of drug resources and have attracted widespread attention. In order to explore biological candidates from the marine cone snail, we isolated and identified three novel conopeptides named as Vi14b, Vi002, Vi003, three ...
Shuang Ju +9 more
doaj +2 more sources
Conotoxin Patenting Trends in Academia and Industry [PDF]
Marine Drugs, 2022 Sea snails of the genus Conus produce toxins that have been the subjects of numerous studies, projects, publications, and patents over the years. Since Conus toxins were discovered in the 1960s, their biological activity has been thought to have high ...
Noemi Sanchez-Campos +2 more
doaj +2 more sources
Transcriptomic Analysis of Marine Gastropod Hemifusus tuba Provides Novel Insights into Conotoxin Genes [PDF]
Marine Drugs, 2019 The marine gastropod Hemifusus tuba is served as a luxury food in Asian countries and used in traditional Chinese medicine to treat lumbago and deafness. The lack of genomic data on H.
Ronghua Li +6 more
doaj +4 more sources
Predatory and Defensive Strategies in Cone Snails [PDF]
ToxinsCone snails are carnivorous marine animals that prey on fish (piscivorous), worms (vermivorous), or other mollusks (molluscivorous). They produce a complex venom mostly made of disulfide-rich conotoxins and conopeptides in a compartmentalized venom gland.
Zahrmina Ratibou +2 more
doaj +2 more sources
Novel Conopeptides of Largely Unexplored Indo Pacific Conus sp. [PDF]
Marine Drugs, 2016 Cone snails are predatory creatures using venom as a weapon for prey capture and defense. Since this venom is neurotoxic, the venom gland is considered as an enormous collection of pharmacologically interesting compounds having a broad spectrum of ...
Eline K. M. Lebbe +9 more
doaj +3 more sources
ConoServer: updated content, knowledge, and discovery tools in the conopeptide database [PDF]
Nucleic Acids Research, 2011 International audienceConoServer (http://www.conoserver.org) is a database specializing in the sequences and structures of conopeptides, which are toxins expressed by marine cone snails. Cone snails are carnivorous gastropods, which hunt their prey using
Craik, David, +4 more
core +9 more sources
Improved prediction of conopeptide superfamilies with ConoDictor 2.0. [PDF]
Bioinform Adv, 2021 Abstract Motivation Cone snails are among the richest sources of natural peptides with promising pharmacological and therapeutic applications. With the reduced costs of RNAseq, scientists now heavily rely on venom gland transcriptomes for the mining of novel bioactive conopeptides, but the ...
Koua D, Ebou A, Dutertre S.
europepmc +3 more sources