Marine Drugs, 2021 Marine cone snails are predatory gastropods characterized by a well-developed venom apparatus and highly evolved hunting strategies that utilize toxins to paralyze prey and defend against predators.
Rajesh Rajaian Pushpabai +4 more
doaj +2 more sources
The ATP-mediated cytokine release by macrophages is down-modulated by unconventional α9* nicotinic acetylcholine receptors [PDF]
Frontiers in ImmunologyObjectiveThe clinical interest in mechanisms controlling the biosynthesis and release of the pro-inflammatory cytokine interleukin (IL)-1β is outstanding, as IL-1β is associated with life-threatening inflammatory diseases including hyperinflammation ...
Philipp M. K. Wolf +20 more
doaj +2 more sources
Biomedical Potential of the Neglected Molluscivorous and Vermivorous Conus Species [PDF]
Marine Drugs, 2022 Within the Conidae family, the piscivorous Conus species have been a hotspot target for drug discovery. Here, we assess the relevance of Conus and their other feeding habits, and thus under distinctive evolutionary constraints, to highlight the potential
Yihe Zhao, Agostinho Antunes
doaj +2 more sources
Conotoxins and other conopeptides
, 2014 Conopeptides are a large family of peptide toxins produced by marine cone snails. They act with high potency and exquisite specificity on a range of ion channels and transporters of the nervous system, making them valuable drug leads and important ...
Quentin Kaas +3 more
core +5 more sources
In the picture: disulfide-poor conopeptides, a class of pharmacologically interesting compounds [PDF]
Journal of Venomous Animals and Toxins including Tropical Diseases, 2016 During evolution, nature has embraced different strategies for species to survive. One strategy, applied by predators as diverse as snakes, scorpions, sea anemones and cone snails, is using venom to immobilize or kill a prey.
Eline K. M. Lebbe, Jan Tytgat
doaj +2 more sources
Anti-Ovarian Cancer Conotoxins Identified from Conus Venom [PDF]
Molecules, 2022 Conotoxins constitute a treasury of drug resources and have attracted widespread attention. In order to explore biological candidates from the marine cone snail, we isolated and identified three novel conopeptides named as Vi14b, Vi002, Vi003, three ...
Shuang Ju +9 more
doaj +2 more sources
Mollusk-Derived Peptides at the Food-Pharma Interface: Bioactivities, Preclinical Evidence, and Development Prospects [PDF]
MoleculesMollusk-derived peptides are an expanding class of marine bioactive molecules that link food-protein utilization with pharmaceutical peptide discovery.
Muhammad Imran +7 more
doaj +2 more sources
Characterization of the
BMC Genomics, 2011 Background The venomous marine gastropods, cone snails (genus Conus), inject prey with a lethal cocktail of conopeptides, small cysteine-rich peptides, each with a high affinity for its molecular target, generally an ion channel, receptor or transporter.
Olivera Baldomero M +3 more
doaj +3 more sources
Therapeutic potential of cone snail venom peptides (conopeptides)
Current Topics in Medicinal Chemistry, 2012 Cone snails have evolved many 1000s of small, structurally stable venom peptides (conopeptides) for prey capture and defense ...
Lewis, Richard J., Vetter, Irina
core +6 more sources
Conopeptides [V11L;V16D]ArIB and RgIA4: Powerful Tools for the Identification of Novel Nicotinic Acetylcholine Receptors in Monocytes [PDF]
Frontiers in Pharmacology, 2019 Venomous marine snails of the genus Conus employ small peptides to capture prey, mainly osteichthyes, mollusks, and worms. A subset of these peptides known as α-conotoxins, are antagonists of nicotinic acetylcholine receptors (nAChRs).
Veronika Grau +5 more
doaj +2 more sources