Diversity of Conopeptides and Their Precursor Genes of Conus Litteratus [PDF]
Marine Drugs, 2020 The venom of various Conus species is composed of a rich variety of unique bioactive peptides, commonly referred to as conotoxins (conopeptides). Most conopeptides have specific receptors or ion channels as physiologically relevant targets. In this paper,
Xinjia Li +3 more
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Hormone-like conopeptides – new tools for pharmaceutical design [PDF]
RSC Medicinal Chemistry, 2020 Conopeptides are a diverse family of peptides found in the venoms of marine cone snails and are used in prey capture and host defence. Because of their potent activity on a range of mammalian targets they have attracted interest as leads in drug design ...
Ashlin H Turner +2 more
exaly +9 more sources
Conopeptides from Cape Verde Conus crotchii [PDF]
Marine Drugs, 2013 Marine Cone snails of the genus Conus contain complex peptide toxins in their venom. Living in tropical habitats, they usually use the powerful venom for self-defense and prey capture.
Agostinho Antunes +4 more
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The first Conus genome assembly reveals a primary genetic central dogma of conopeptides in C. betulinus [PDF]
Cell Discovery, 2021 Although there are various Conus species with publicly available transcriptome and proteome data, no genome assembly has been reported yet. Here, using Chinese tubular cone snail (C.
Chao Peng +24 more
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Marine Origin Ligands of Nicotinic Receptors: Low Molecular Compounds, Peptides and Proteins for Fundamental Research and Practical Applications [PDF]
Biomolecules, 2022 The purpose of our review is to briefly show what different compounds of marine origin, from low molecular weight ones to peptides and proteins, offer for understanding the structure and mechanism of action of nicotinic acetylcholine receptors (nAChRs ...
Igor Kasheverov +5 more
doaj +2 more sources
δ-Conotoxin Structure Prediction and Analysis through Large-Scale Comparative and Deep Learning Modeling Approaches. [PDF]
Adv Sci (Weinh)δ‐Conotoxins are a diverse class of peptides that inhibit the inactivation of voltage‐gated sodium channels – proteins implicated in many human diseases – but which remain poorly characterized. Computational modeling of 18 different δ‐conotoxins using traditional and deep learning techniques uncovers structural features underlying the varying ...
McCarthy S, Gonen S.
europepmc +2 more sources
Identification of Novel Conotoxin Precursors from the Cone Snail Conus spurius by High-Throughput RNA Sequencing [PDF]
Marine Drugs, 2021 Marine gastropods of the genus Conus, comprising more than 800 species, have the characteristic of injecting worms and other prey with venom. These conopeptide toxins, highly diverse in structure and action, are highly potent and specific for their ...
Roberto Zamora-Bustillos +4 more
doaj +2 more sources
Proteomic analysis of the venom of Conus flavidus from Red Sea reveals potential pharmacological applications [PDF]
Journal of Genetic Engineering and BiotechnologyBackground: Venomous marine cone snails produce unique neurotoxins called conopeptides or conotoxins, which are valuable for research and drug discovery.
Mousa O. Germoush +9 more
doaj +2 more sources
Single-Disulfide Conopeptide Czon1107, an Allosteric Antagonist of the Human α3β4 Nicotinic Acetylcholine Receptor [PDF]
Marine Drugs, 2022 Conopeptides are peptides in the venom of marine cone snails that are used for capturing prey or as a defense against predators. A new cysteine-poor conopeptide, Czon1107, has exhibited non-competitive inhibition with an undefined allosteric mechanism in
Yuan Ma +9 more
doaj +2 more sources
Peptide Toxins from Marine Conus Snails with Activity on Potassium Channels and/or Currents [PDF]
ToxinsToxins from Conus snails are peptides characterized by a great structural and functional diversity. They have a high affinity for a wide range of membrane proteins such as ion channels, neurotransmitter transporters, and G protein-coupled receptors ...
Luis Martínez-Hernández +2 more
doaj +2 more sources