Snails In Silico: A Review of Computational Studies on the Conopeptides [PDF]
Marine Drugs, 2019 Marine cone snails are carnivorous gastropods that use peptide toxins called conopeptides both as a defense mechanism and as a means to immobilize and kill their prey.
Rachael A Mansbach +2 more
exaly +5 more sources
Diversity of Conopeptides and Their Precursor Genes of Conus Litteratus [PDF]
Marine Drugs, 2020 The venom of various Conus species is composed of a rich variety of unique bioactive peptides, commonly referred to as conotoxins (conopeptides). Most conopeptides have specific receptors or ion channels as physiologically relevant targets. In this paper,
Xinjia Li +3 more
doaj +5 more sources
In the picture: disulfide-poor conopeptides, a class of pharmacologically interesting compounds [PDF]
Journal of Venomous Animals and Toxins including Tropical Diseases, 2016 During evolution, nature has embraced different strategies for species to survive. One strategy, applied by predators as diverse as snakes, scorpions, sea anemones and cone snails, is using venom to immobilize or kill a prey.
Eline K. M. Lebbe, Jan Tytgat
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Hormone-like conopeptides – new tools for pharmaceutical design [PDF]
RSC Medicinal Chemistry, 2020 Marine cone snails produce an array of hormone-like peptides in their venom, providing bioactive leads for developing peptide drugs and small molecule mimetics.
Ashlin H Turner +2 more
exaly +7 more sources
The first Conus genome assembly reveals a primary genetic central dogma of conopeptides in C. betulinus [PDF]
Cell Discovery, 2021 Although there are various Conus species with publicly available transcriptome and proteome data, no genome assembly has been reported yet. Here, using Chinese tubular cone snail (C.
Chao Peng +24 more
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Identification of Novel Conotoxin Precursors from the Cone Snail Conus spurius by High-Throughput RNA Sequencing [PDF]
Marine Drugs, 2021 Marine gastropods of the genus Conus, comprising more than 800 species, have the characteristic of injecting worms and other prey with venom. These conopeptide toxins, highly diverse in structure and action, are highly potent and specific for their ...
Roberto Zamora-Bustillos +4 more
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Proteomic analysis of the venom of Conus flavidus from Red Sea reveals potential pharmacological applications [PDF]
Journal of Genetic Engineering and BiotechnologyBackground: Venomous marine cone snails produce unique neurotoxins called conopeptides or conotoxins, which are valuable for research and drug discovery.
Mousa O. Germoush +9 more
doaj +2 more sources
Single-Disulfide Conopeptide Czon1107, an Allosteric Antagonist of the Human α3β4 Nicotinic Acetylcholine Receptor [PDF]
Marine Drugs, 2022 Conopeptides are peptides in the venom of marine cone snails that are used for capturing prey or as a defense against predators. A new cysteine-poor conopeptide, Czon1107, has exhibited non-competitive inhibition with an undefined allosteric mechanism in
Yuan Ma +9 more
doaj +2 more sources
Peptide Toxins from Marine Conus Snails with Activity on Potassium Channels and/or Currents [PDF]
ToxinsToxins from Conus snails are peptides characterized by a great structural and functional diversity. They have a high affinity for a wide range of membrane proteins such as ion channels, neurotransmitter transporters, and G protein-coupled receptors ...
Luis Martínez-Hernández +2 more
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Non-Peptidic Small Molecule Components from Cone Snail Venoms [PDF]
Frontiers in Pharmacology, 2021 Venomous molluscs (Superfamily Conoidea) comprise a substantial fraction of tropical marine biodiversity (>15,000 species). Prior characterization of cone snail venoms established that bioactive venom components used to capture prey, defend against ...
Zhenjian Lin +14 more
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